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Vilar M, Mira H. Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles. Front Neurosci. 2016;10:26doi: 10.3389/fnins.2016.00026.
Vilar, M., & Mira, H. (2016). Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles. Frontiers in neuroscience, 1026. https://doi.org/10.3389/fnins.2016.00026
Vilar, Marçal, and Mira, Helena. "Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles." Frontiers in neuroscience vol. 10 (2016): 26. doi: https://doi.org/10.3389/fnins.2016.00026
Vilar M, Mira H. Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles. Front Neurosci. 2016 Feb 09;10:26. doi: 10.3389/fnins.2016.00026. eCollection 2016. PMID: 26903794; PMCID: PMC4746328.
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Front Neurosci. 2016 Feb 09;10:26. doi: 10.3389/fnins.2016.00026. eCollection 2016.

Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles.

Frontiers in neuroscience

Marçal Vilar, Helena Mira

Affiliations

  1. Neurodegeneration Unit, Unidad Funcional de Investigación de Enfermedades Crónicas-Instituto de Salud Carlos III Madrid, Spain.
  2. Molecular Neurobiology Unit, Unidad Funcional de Investigación de Enfermedades Crónicas-Instituto de Salud Carlos III Madrid, Spain.

PMID: 26903794 PMCID: PMC4746328 DOI: 10.3389/fnins.2016.00026

Abstract

The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in which neurogenesis is maintained throughout life. Because alterations in adult neurogenesis appear to be a common hallmark of different neurodegenerative diseases, understanding the molecular mechanisms controlling adult neurogenesis is a focus of active research. Neurotrophic factors are a family of molecules that play critical roles in the survival and differentiation of neurons during development and in the control of neural plasticity in the adult. Several neurotrophins and neurotrophin receptors have been implicated in the regulation of adult neurogenesis at different levels. Here, we review the current understanding of neurotrophin modulation of adult neurogenesis in both the SVZ and SGZ. We compile data supporting a variety of roles for neurotrophins/neurotrophin receptors in different scenarios, including both expected and unexpected functions.

Keywords: BDNF; NT3; TrkB; adult neurogenesis; neural stem cell; neurotrophin; p75NTR

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