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Zimmerman SC. A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy. Beilstein J Org Chem. 2016;12:125-38doi: 10.3762/bjoc.12.14.
Zimmerman, S. C. (2016). A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy. Beilstein journal of organic chemistry, 12125-38. https://doi.org/10.3762/bjoc.12.14
Zimmerman, Steven C. "A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy." Beilstein journal of organic chemistry vol. 12 (2016): 125-38. doi: https://doi.org/10.3762/bjoc.12.14
Zimmerman SC. A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy. Beilstein J Org Chem. 2016 Jan 25;12:125-38. doi: 10.3762/bjoc.12.14. eCollection 2016. PMID: 26877815; PMCID: PMC4734311.
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Beilstein J Org Chem. 2016 Jan 25;12:125-38. doi: 10.3762/bjoc.12.14. eCollection 2016.

A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy.

Beilstein journal of organic chemistry

Steven C Zimmerman

Affiliations

  1. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

PMID: 26877815 PMCID: PMC4734311 DOI: 10.3762/bjoc.12.14

Abstract

This review summarizes part of the author's research in the area of supramolecular chemistry, beginning with his early life influences and early career efforts in molecular recognition, especially molecular tweezers. Although designed to complex DNA, these hosts proved more applicable to the field of host-guest chemistry. This early experience and interest in intercalation ultimately led to the current efforts to develop small molecule therapeutic agents for myotonic dystrophy using a rational design approach that heavily relies on principles of supramolecular chemistry. How this work was influenced by that of others in the field and the evolution of each area of research is highlighted with selected examples.

Keywords: RNA recognition; RNase mimic; catenanes; intercalation; macrocycles; multi-target drug discovery

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