Display options
Cite
Sahu CR. Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L. Clin Med Insights Arthritis Musculoskelet Disord. 2016;9:9-13doi: 10.4137/CMAMD.S29463.
Sahu, C. R. (2016). Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L. Clinical medicine insights. Arthritis and musculoskeletal disorders, 99-13. https://doi.org/10.4137/CMAMD.S29463
Sahu, C R. "Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L." Clinical medicine insights. Arthritis and musculoskeletal disorders vol. 9 (2016): 9-13. doi: https://doi.org/10.4137/CMAMD.S29463
Sahu CR. Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L. Clin Med Insights Arthritis Musculoskelet Disord. 2016 Jan 19;9:9-13. doi: 10.4137/CMAMD.S29463. eCollection 2016. PMID: 26819562; PMCID: PMC4720181.
Copy Download .nbib Format: NLM
Share it on

Clin Med Insights Arthritis Musculoskelet Disord. 2016 Jan 19;9:9-13. doi: 10.4137/CMAMD.S29463. eCollection 2016.

Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus rosa-sinensis L.

Clinical medicine insights. Arthritis and musculoskeletal disorders

C R Sahu

Affiliations

  1. Department of Zoology, University of Kalyani, Kalyani, India.

PMID: 26819562 PMCID: PMC4720181 DOI: 10.4137/CMAMD.S29463

Abstract

Piroxicam is one of the important therapeutic nonsteroidal anti-inflammatory class of drugs used mainly to suppress pain and inflammation in arthritis and other musculoskeletal disorders. Besides being anti-inflammatory, these drugs are analgesic and antipyretic often used for the relief of nonspecific fever condition. Recently, piroxicam has also gained attention as an effective therapy for tumors, colorectal, and invasive bladder cancers. The objective of the current study is to evaluate the protective effects of the alcoholic leaf extract of Hibiscus rosa-sinensis (AEH), Malvaceae, against piroxicam-induced toxicity in mice. Sixty adult Swiss albino mice (Mus musculus) were divided into four groups (n = 10), which included a control group, a group treated orally with AEH (30 mg kg(-1) b.w.) for 15 days, a group treated orally with piroxicam (6.6 mg kg(-1) b.w.) for 15 days, and another group treated orally with piroxicam and AEH for 15 days. The results indicated that treatment with piroxicam alone resulted in a significant increase in the activities of serum marker enzymes, namely, aspartate transaminase, alanine transaminase, and alkaline phosphatase with profound hepatic lipid peroxidation as evidenced by a marked increment in the level of thoibarbituric acid reactive substances along with a distinct diminution in reduced glutathoine content and various antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase in the liver. However, treatment with AEH during piroxicam treatment retrieved or partially antagonized the effects induced by piroxicam toward the normal values of controls. Histopathological observations also corroborate with the above findings. It can be concluded that AEH exhibited a protective action against piroxicam toxicity and effective in combating oxidative stress-induced hepatic damage.

Keywords: Hibiscus rosa-sinensis L; hepatotoxicity; oxidative stress – related enzymes; piroxicam; serum enzymes

References

  1. Clin Liver Dis. 2007 Aug;11(3):563-75, vi-vii - PubMed
  2. Annu Rev Pharmacol Toxicol. 1993;33:435-65 - PubMed
  3. Eur Respir J. 2000 Sep;16(3):534-54 - PubMed
  4. J Agric Food Chem. 2000 Jun;48(6):2008-16 - PubMed
  5. Chem Biol Interact. 2002 Nov 10;142(1-2):25-41 - PubMed
  6. Nat Rev Rheumatol. 2011 Mar;7(3):139-50 - PubMed
  7. Annu Rev Pharmacol Toxicol. 1998;38:97-120 - PubMed
  8. Science. 1973 Feb 9;179(4073):588-90 - PubMed
  9. Arthritis Res. 2000;2(5):379-85 - PubMed
  10. Eur J Biochem. 1968 Oct 17;6(1):126-30 - PubMed
  11. Arthritis Rheum. 1989 Jan;32(1):1-9 - PubMed
  12. World J Gastroenterol. 2010 Dec 7;16(45):5651-61 - PubMed
  13. J Agric Food Chem. 2000 Nov;48(11):5677-84 - PubMed
  14. Curr Pharm Des. 2000 Nov;6(17):1693-724 - PubMed
  15. J Ethnopharmacol. 2001 Dec;78(2-3):151-7 - PubMed
  16. J Clin Pathol. 1954 Nov;7(4):322-6 - PubMed
  17. Ann Rheum Dis. 2010 Sep;69(9):1612-7 - PubMed
  18. Food Chem Toxicol. 2002 May;40(5):635-41 - PubMed
  19. Expert Opin Drug Saf. 2014 Jan;13(1):67-81 - PubMed
  20. Natl Med J India. 2000 Nov-Dec;13(6):304-10 - PubMed
  21. Arch Biochem Biophys. 1959 May;82(1):70-7 - PubMed
  22. Annu Rev Nutr. 1996;16:33-50 - PubMed
  23. Anal Biochem. 1972 Jun;47(2):389-94 - PubMed
  24. Life Sci. 2005 Jun 3;77(3):266-78 - PubMed
  25. BMC Complement Altern Med. 2014 Jul 30;14:277 - PubMed
  26. Biochem Biophys Res Commun. 1998 Jan 6;242(1):1-9 - PubMed
  27. Dig Dis. 2015 ;33(4):486-91 - PubMed
  28. J Agric Food Chem. 1999 Jan;47(1):36-41 - PubMed
  29. Expert Opin Drug Saf. 2007 Nov;6(6):673-84 - PubMed
  30. Food Nutr Res. 2015 Oct 15;59:29018 - PubMed
  31. Am J Clin Pathol. 1957 Jul;28(1):56-63 - PubMed
  32. Mayo Clin Proc. 2014 Jan;89(1):95-106 - PubMed

Publication Types