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Moy MP, Sauk J, Gee MS. The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response. Gastroenterol Res Pract. 2015;2016:8168695doi: 10.1155/2016/8168695.
Moy, M. P., Sauk, J., & Gee, M. S. (2016). The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response. Gastroenterology research and practice, 20168168695. https://doi.org/10.1155/2016/8168695
Moy, Matthew P, et al. "The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response." Gastroenterology research and practice vol. 2016 (2016): 8168695. doi: https://doi.org/10.1155/2016/8168695
Moy MP, Sauk J, Gee MS. The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response. Gastroenterol Res Pract. 2016;2016:8168695. doi: 10.1155/2016/8168695. Epub 2015 Dec 27. PMID: 26819611; PMCID: PMC4706951.
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Gastroenterol Res Pract. 2016;2016:8168695. doi: 10.1155/2016/8168695. Epub 2015 Dec 27.

The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response.

Gastroenterology research and practice

Matthew P Moy, Jenny Sauk, Michael S Gee

Affiliations

  1. Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Division of Pediatric Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  2. Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

PMID: 26819611 PMCID: PMC4706951 DOI: 10.1155/2016/8168695

Abstract

MR enterography (MRE) has become the primary imaging modality in the assessment of Crohn's disease (CD) in both children and adults at many institutions in the United States and worldwide, primarily due to its noninvasiveness, superior soft tissue contrast, and lack of ionizing radiation. MRE technique includes distention of the small bowel with oral contrast media with the acquisition of T2-weighted, balanced steady-state free precession, and multiphase T1-weighted fat suppressed gadolinium contrast-enhanced sequences. With the introduction of molecule-targeted biologic agents into the clinical setting for CD and their potential to reverse the inflammatory process, MRE is increasingly utilized to evaluate disease activity and response to therapy as an imaging complement to clinical indices or optical endoscopy. New and emerging MRE techniques, such as diffusion-weighted imaging (DWI), magnetization transfer, ultrasmall superparamagnetic iron oxide- (USPIO-) enhanced MRI, and PET-MR, offer the potential for an expanded role of MRI in detecting occult disease activity, evaluating early treatment response/resistance, and differentiating inflammatory from fibrotic strictures. Familiarity with MR enterography is essential for radiologists and gastroenterologists as the technique evolves and is further incorporated into the clinical management of CD.

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