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Biggar P, Fung SK, Ketteler M. Treatment of phosphate retention: The earlier the better?. Kidney Res Clin Pract. 2014;33(1):3-8doi: 10.1016/j.krcp.2013.11.004.
Biggar, P., Fung, S. K., & Ketteler, M. (2014). Treatment of phosphate retention: The earlier the better?. Kidney research and clinical practice, 33(1), 3-8. https://doi.org/10.1016/j.krcp.2013.11.004
Biggar, Patrick, et al. "Treatment of phosphate retention: The earlier the better?." Kidney research and clinical practice vol. 33,1 (2014): 3-8. doi: https://doi.org/10.1016/j.krcp.2013.11.004
Biggar P, Fung SK, Ketteler M. Treatment of phosphate retention: The earlier the better?. Kidney Res Clin Pract. 2014 Mar;33(1):3-8. doi: 10.1016/j.krcp.2013.11.004. Epub 2014 Feb 03. PMID: 26877944; PMCID: PMC4714155.
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Kidney Res Clin Pract. 2014 Mar;33(1):3-8. doi: 10.1016/j.krcp.2013.11.004. Epub 2014 Feb 03.

Treatment of phosphate retention: The earlier the better?.

Kidney research and clinical practice

Patrick Biggar, Samuel K S Fung, Markus Ketteler

Affiliations

  1. Klinikum Coburg GmbH, Department of Nephrology, Coburg, Germany.
  2. Princess Margaret Hospital, Kowloon West Cluster Hospital Authority, Kowloon, Hong Kong SAR, China.

PMID: 26877944 PMCID: PMC4714155 DOI: 10.1016/j.krcp.2013.11.004

Abstract

Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20(th) century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is increasingly perceived to be a major trigger of vascular and soft tissue calcification. The current treatment options are discussed in view of historical developments and the expectations of the foreseeable future, focusing on the early treatment of hyperphosphatemia. At present, we lack indisputable evidence that active intervention using currently available drugs is of benefit to patients in chronic kidney disease stages 3 and 4.

Keywords: Calcification; Chronic kidney disease; FGF-23; Hyperphosphatemia; Phosphate binders; Prognosis

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