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Kalra S, Zargar AH, Jain SM, et al. Diabetes insipidus: The other diabetes. Indian J Endocrinol Metab. 2016;20(1):9-21doi: 10.4103/2230-8210.172273.
Kalra, S., Zargar, A. H., Jain, S. M., Sethi, B., Chowdhury, S., Singh, A. K., Thomas, N., Unnikrishnan, A. G., Thakkar, P. B., & Malve, H. (2016). Diabetes insipidus: The other diabetes. Indian journal of endocrinology and metabolism, 20(1), 9-21. https://doi.org/10.4103/2230-8210.172273
Kalra, Sanjay, et al. "Diabetes insipidus: The other diabetes." Indian journal of endocrinology and metabolism vol. 20,1 (2016): 9-21. doi: https://doi.org/10.4103/2230-8210.172273
Kalra S, Zargar AH, Jain SM, Sethi B, Chowdhury S, Singh AK, Thomas N, Unnikrishnan AG, Thakkar PB, Malve H. Diabetes insipidus: The other diabetes. Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):9-21. doi: 10.4103/2230-8210.172273. PMID: 26904464; PMCID: PMC4743391.
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Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):9-21. doi: 10.4103/2230-8210.172273.

Diabetes insipidus: The other diabetes.

Indian journal of endocrinology and metabolism

Sanjay Kalra, Abdul Hamid Zargar, Sunil M Jain, Bipin Sethi, Subhankar Chowdhury, Awadhesh Kumar Singh, Nihal Thomas, A G Unnikrishnan, Piya Ballani Thakkar, Harshad Malve

Affiliations

  1. Bharti Hospital and BRIDE, Karnal, Haryana, India.
  2. Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
  3. Managing Director, TOTALL Diabetes Hormone Institute, Indore, Madhya Pradesh, India.
  4. Consultant Endocrinologist, CARE Hospitals, Hyderabad, Telangana, India.
  5. Department of Endocrinology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.
  6. GD Diabetes Institute, Kolkata, West Bengal, India; Sun Valley Diabetes and Endocrine Research Centre, Guwahati, Assam, India.
  7. Department of Endocrinology, Diabetes and Metabolism and Vice-Principal (Research), Christian Medical College, Vellore, Tamil Nadu, India.
  8. Chellaram Diabetes Institute, Pune, Maharashtra, India.
  9. Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
  10. Lead Medical, Asia Pacific region, Ferring Pharmaceuticals Pvt. Ltd., Mumbai, Maharashtra, India.

PMID: 26904464 PMCID: PMC4743391 DOI: 10.4103/2230-8210.172273

Abstract

Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for the purpose of this review. Central DI due to impaired secretion of arginine vasopressin (AVP) could result from traumatic brain injury, surgery, or tumors whereas nephrogenic DI due to failure of the kidney to respond to AVP is usually inherited. The earliest treatment was posterior pituitary extracts containing vasopressin and oxytocin. The synthetic analog of vasopressin, desmopressin has several benefits over vasopressin. Desmopressin was initially available as intranasal preparation, but now the oral tablet and melt formulations have gained significance, with benefits such as ease of administration and stability at room temperature. Other molecules used for treatment include chlorpropamide, carbamazepine, thiazide diuretics, indapamide, clofibrate, indomethacin, and amiloride. However, desmopressin remains the most widely used drug for the treatment of DI. This review covers the physiology of water balance, causes of DI and various treatment modalities available, with a special focus on desmopressin.

Keywords: Antidiuretic hormone; desmopressin; polydipsia; polyuria; vasopressin

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