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Ktsoyan Z, Ghazaryan K, Manukyan G, et al. Inflammatory Responses to Salmonella Infections Are Serotype-Specific. Int J Bacteriol. 2013;2013:168179doi: 10.1155/2013/168179.
Ktsoyan, Z., Ghazaryan, K., Manukyan, G., Martirosyan, A., Mnatsakanyan, A., Arakelova, K., Gevorgyan, Z., Sedrakyan, A., Asoyan, A., Boyajyan, A., & Aminov, R. (2013). Inflammatory Responses to Salmonella Infections Are Serotype-Specific. International journal of bacteriology, 2013168179. https://doi.org/10.1155/2013/168179
Ktsoyan, Zhanna, et al. "Inflammatory Responses to Salmonella Infections Are Serotype-Specific." International journal of bacteriology vol. 2013 (2013): 168179. doi: https://doi.org/10.1155/2013/168179
Ktsoyan Z, Ghazaryan K, Manukyan G, Martirosyan A, Mnatsakanyan A, Arakelova K, Gevorgyan Z, Sedrakyan A, Asoyan A, Boyajyan A, Aminov R. Inflammatory Responses to Salmonella Infections Are Serotype-Specific. Int J Bacteriol. 2013;2013:168179. doi: 10.1155/2013/168179. Epub 2013 Sep 16. PMID: 26904722; PMCID: PMC4745457.
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Int J Bacteriol. 2013;2013:168179. doi: 10.1155/2013/168179. Epub 2013 Sep 16.

Inflammatory Responses to Salmonella Infections Are Serotype-Specific.

International journal of bacteriology

Zhanna Ktsoyan, Karine Ghazaryan, Gayane Manukyan, Anush Martirosyan, Armine Mnatsakanyan, Karine Arakelova, Zaruhi Gevorgyan, Anahit Sedrakyan, Ara Asoyan, Anna Boyajyan, Rustam Aminov

Affiliations

  1. Institute of Molecular Biology National Academy of Sciences of Republic of Armenia, Hasratyan 7, 0014 Yerevan, Armenia.
  2. "Nork" Clinical Hospital of Infectious Diseases, Ministry of Health of Republic of Armenia, Armenakyan 153, 0047 Yerevan, Armenia.
  3. Faculty of Medical Sciences, University of the West Indies, Mona, Kingston 7, Jamaica.

PMID: 26904722 PMCID: PMC4745457 DOI: 10.1155/2013/168179

Abstract

The main purpose of this study was to investigate the profile of inflammatory response in patients with acute salmonellosis caused by two serotypes of Salmonella enterica, S. Enteritidis and S. Typhimurium, as well as in convalescent patients with previous acute disease caused by S. Enteritidis. Patients with acute disease showed significantly elevated levels of IL-1β, IL-17, IL-10, and calprotectin compared to healthy control subjects. In convalescent patients, these markers were also significantly elevated, with the exception of IL-1β. Multivariate statistical analyses with the use of these variables produced models with a good predictive accuracy resulting in excellent separation of the diseased and healthy cohorts studied. Overall, the results suggest that the profile of inflammatory response in this disease is determined, to a significant degree, by the serotype of Salmonella, and the profile of certain cytokines and calprotectin remains abnormal for a number of months following the acute disease stage.

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