Display options
Cite
Shah PB, Cooper JE, Lucia MS, et al. APOL1 Polymorphisms in a Deceased Donor and Early Presentation of Collapsing Glomerulopathy and Focal Segmental Glomerulosclerosis in Two Recipients. Am J Transplant. 2016;16(6):1923-1927doi: 10.1111/ajt.13748.
Shah, P. B., Cooper, J. E., Lucia, M. S., Boils, C., Larsen, C. P., & Wiseman, A. C. (2016). APOL1 Polymorphisms in a Deceased Donor and Early Presentation of Collapsing Glomerulopathy and Focal Segmental Glomerulosclerosis in Two Recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 16(6), 1923-1927. https://doi.org/10.1111/ajt.13748
Shah, P B, et al. "APOL1 Polymorphisms in a Deceased Donor and Early Presentation of Collapsing Glomerulopathy and Focal Segmental Glomerulosclerosis in Two Recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons vol. 16,6 (2016): 1923-1927. doi: https://doi.org/10.1111/ajt.13748
Shah PB, Cooper JE, Lucia MS, Boils C, Larsen CP, Wiseman AC. APOL1 Polymorphisms in a Deceased Donor and Early Presentation of Collapsing Glomerulopathy and Focal Segmental Glomerulosclerosis in Two Recipients. Am J Transplant. 2016 Jun;16(6):1923-1927. doi: 10.1111/ajt.13748. Epub 2016 Mar 29. PMID: 26849829.
Copy Download .nbib Format: NLM
Share it on

Am J Transplant. 2016 Jun;16(6):1923-1927. doi: 10.1111/ajt.13748. Epub 2016 Mar 29.

APOL1 Polymorphisms in a Deceased Donor and Early Presentation of Collapsing Glomerulopathy and Focal Segmental Glomerulosclerosis in Two Recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

P B Shah, J E Cooper, M S Lucia, C Boils, C P Larsen, A C Wiseman

Affiliations

  1. Division of Renal Diseases and Hypertension, Transplant Center, University of Colorado Denver, Aurora, CO.
  2. Department of Pathology, University of Colorado Denver, Aurora, CO.
  3. Nephropath, Little Rock, AR.

PMID: 26849829 DOI: 10.1111/ajt.13748

Abstract

Two common polymorphisms in APOL1 (G1 and G2) are conserved in persons of African ancestry, and the presence of two polymorphisms (commonly referred to as risk variants) has been identified as a risk factor for chronic kidney disease and focal seg-mental glomerulosclerosis. In kidney transplantation, deceased donors with two APOL1 risk variants carry an increased risk of renal allograft failure in the recipient. An emerging question is whether these data should influence deceased donor assessment or be used to refine prediction of allograft survival. We present the first detailed report of two cases of recipient glomerular disease in the first year following transplant from a deceased donor later defined as carrying two APOL1 risk variants. A possible "second hit" predisposing to renal disease in these recipients is discussed, one with active cytomegalovirus infection concurrent with collapsing glomerulopathy and renal failure and the other with chronic, slowly healing wound infection and focal segmental glomeru-losclerosis but stable renal function. In retrospect, awareness of the donor APOL1 risk alleles would not have influenced donor selection and ultimately did not influence posttransplant management. These case reports inform further discussion of the value of APOL1 testing for deceased donors.

© Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.

Publication Types