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Pawlikowski M, Jaranowska M, Pisarek H, et al. Ectopic expression of follicle-stimulating hormone receptors in thyroid tumors. Arch Med Sci. 2015;11(6):1314-7doi: 10.5114/aoms.2015.56357.
Pawlikowski, M., Jaranowska, M., Pisarek, H., Kubiak, R., Fuss-Chmielewska, J., & Winczyk, K. (2015). Ectopic expression of follicle-stimulating hormone receptors in thyroid tumors. Archives of medical science : AMS, 11(6), 1314-7. https://doi.org/10.5114/aoms.2015.56357
Pawlikowski, Marek, et al. "Ectopic expression of follicle-stimulating hormone receptors in thyroid tumors." Archives of medical science : AMS vol. 11,6 (2015): 1314-7. doi: https://doi.org/10.5114/aoms.2015.56357
Pawlikowski M, Jaranowska M, Pisarek H, Kubiak R, Fuss-Chmielewska J, Winczyk K. Ectopic expression of follicle-stimulating hormone receptors in thyroid tumors. Arch Med Sci. 2015 Dec 10;11(6):1314-7. doi: 10.5114/aoms.2015.56357. Epub 2015 Dec 11. PMID: 26788096; PMCID: PMC4697062.
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Arch Med Sci. 2015 Dec 10;11(6):1314-7. doi: 10.5114/aoms.2015.56357. Epub 2015 Dec 11.

Ectopic expression of follicle-stimulating hormone receptors in thyroid tumors.

Archives of medical science : AMS

Marek Pawlikowski, Maria Jaranowska, Hanna Pisarek, Robert Kubiak, Julita Fuss-Chmielewska, Katarzyna Winczyk

Affiliations

  1. Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Lodz, Poland.
  2. Department of Neuroendocrinology, Chair of Laboratory Medicine, Medical University of Lodz, Lodz, Poland.
  3. Department of Pathology of Tumors, Chair of Oncology, Medical University of Lodz, Lodz, Poland.

PMID: 26788096 PMCID: PMC4697062 DOI: 10.5114/aoms.2015.56357

Abstract

INTRODUCTION: In normal conditions follicle-stimulating hormone receptors (FSHR) are expressed in the ovary and the testis. They can also be expressed in gonadal tumors. However, recently we have found FSHR immunostaining in pituitary adenomas, adrenal tumors and neuroendocrine tumors (carcinoids). The aim of this study was to determine whether the same occurs in thyroid tumors.

MATERIAL AND METHODS: Thirty-six samples of surgically excised thyroids were examined. Follicle-stimulating hormone receptors immunostaining was performed on paraffin sections using the rabbit anti-human FSHR polyclonal antibody raised against a 1-190 amino acid sequence from the human FSHR (sc-13935, Santa Cruz).

RESULTS: Normal thyroid follicles do not show immunopositivity for FSHR. The same concerns the majority of benign lesions, diagnosed as hyperplasia nodularis or thyroid adenomas. However, positive FSHR immunostaining in some follicles was observed. In all but one thyroid cancer (15 papillary, 10 follicular cancers and one case of anaplastic thyroid cancer) 10-100% of tumor cells exhibit positive FSHR immunostaining. In about 40% of samples FSHR immunoreactivity can be observed also in the endothelia of intrathyroidal blood vessels. This immunopositivity was more frequent in the samples of thyroid cancers (13/27) than in benign lesions (2/9).

CONCLUSIONS: Ectopic positive FSHR immunostaining is also present in thyroid cancers, and, to a lesser degree, in benign lesions but not in the normal thyroid epithelium.

Keywords: follicular cancer; nodular hyperplasia; papillary cancer

References

  1. J Cell Mol Med. 2012 Sep;16(9):2010-6 - PubMed
  2. Histopathology. 2013 Jul;63(1):29-35 - PubMed
  3. J Gynecol Oncol. 2010 Jun;21(2):119-24 - PubMed
  4. J Cell Physiol. 2011 Jun;226(6):1608-19 - PubMed
  5. Mol Cell Endocrinol. 2010 Nov 25;329(1-2):56-61 - PubMed
  6. Clin Med Insights Oncol. 2012;6:381-93 - PubMed
  7. Arch Med Sci. 2013 Feb 21;9(1):74-8 - PubMed
  8. J Endocrinol Invest. 2013 Mar;36(3):174-9 - PubMed
  9. Folia Histochem Cytobiol. 2012 Oct 08;50(3):325-30 - PubMed
  10. Biol Reprod. 2011 Jan;84(1):7-17 - PubMed
  11. J Urol. 1999 Mar;161(3):970-6 - PubMed
  12. Endocr Relat Cancer. 2010 Nov 30;18(1):13-26 - PubMed
  13. Endokrynol Pol. 2013;64(4):268-71 - PubMed
  14. Endocr Rev. 1997 Dec;18(6):739-73 - PubMed
  15. N Engl J Med. 2010 Oct 21;363(17):1621-30 - PubMed

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