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Levy RJ, Labhasetwar V, Strickberger SA, et al. Controlled release implant dosage forms for cardiac arrhythmias: Review and perspectives. Drug Deliv. 1996;3(3):137-42doi: 10.3109/10717549609029442.
Levy, R. J., Labhasetwar, V., Strickberger, S. A., Underwood, T., & Davis, J. (1996). Controlled release implant dosage forms for cardiac arrhythmias: Review and perspectives. Drug delivery, 3(3), 137-42. https://doi.org/10.3109/10717549609029442
Levy, R J, et al. "Controlled release implant dosage forms for cardiac arrhythmias: Review and perspectives." Drug delivery vol. 3,3 (1996): 137-42. doi: https://doi.org/10.3109/10717549609029442
Levy RJ, Labhasetwar V, Strickberger SA, Underwood T, Davis J. Controlled release implant dosage forms for cardiac arrhythmias: Review and perspectives. Drug Deliv. 1996;3(3):137-42. doi: 10.3109/10717549609029442. PMID: 26790908.
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Drug Deliv. 1996;3(3):137-42. doi: 10.3109/10717549609029442.

Controlled release implant dosage forms for cardiac arrhythmias: Review and perspectives.

Drug delivery

R J Levy, V Labhasetwar, S A Strickberger, T Underwood, J Davis

Affiliations

  1. a Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  2. b Department of Pharmaceutics, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.
  3. c Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  4. d Department of Pediatrics and Communicable Diseases and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

PMID: 26790908 DOI: 10.3109/10717549609029442

Abstract

Cardiac implants using drug-polymer systems for the release of anti-arrhythmic agents directly to the myocardium have been successfully utilized in experimental studies for preventing and treating arrhythmias. This approach is hypothesized to be optimal since anti-arrhythmic agents are provided directly to the heart, and therefore the possibility of systemic side effects is reduced. Furthermore, anti-arrhythmic agents with poor oral bioavailability or with first-pass clearance characteristics following intravenous administration, such as the class III agent ibutilide, are optimally used by the direct cardiac route of administration. Cardiac controlled release implants have been demonstrated to be effective for optimizing the therapy of ventricular tachycardia, ventricular fibrillation, and atrial flutter. Monolithic matrices have been used for fixed rate release kinetics, and modulation of release has been possible through the use of iontophoretic drug delivery systems. Future implants will interface with forefront strategies in tissue engineering and molecular genetics to provide optimal therapy of the diseased arrhythmogenic myocardium.

Keywords: Drug Delivery; Local Therapy; Polymer Implants

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