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Almeida LS, Barboza JR, Freitas FPS, et al. Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats. Hum Exp Toxicol. 2016;35(11):1194-1202doi: 10.1177/0960327115626582.
Almeida, L. S., Barboza, J. R., Freitas, F. P. S., Porto, M. L., Vasquez, E. C., Meyrelles, S. S., Gava, A. L., & Pereira, T. M. C. (2016). Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats. Human & experimental toxicology, 35(11), 1194-1202. https://doi.org/10.1177/0960327115626582
Almeida, Lais Salles de, et al. "Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats." Human & experimental toxicology vol. 35,11 (2016): 1194-1202. doi: https://doi.org/10.1177/0960327115626582
Almeida LS, Barboza JR, Freitas FPS, Porto ML, Vasquez EC, Meyrelles SS, Gava AL, Pereira TMC. Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats. Hum Exp Toxicol. 2016 Nov;35(11):1194-1202. doi: 10.1177/0960327115626582. Epub 2016 Jul 11. PMID: 26791539.
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Hum Exp Toxicol. 2016 Nov;35(11):1194-1202. doi: 10.1177/0960327115626582. Epub 2016 Jul 11.

Sildenafil prevents renal dysfunction in contrast media-induced nephropathy in Wistar rats.

Human & experimental toxicology

Lais Salles de Almeida, Jamila Rodrigues Barboza, Flávia Priscila Santos Freitas, Marcella Leite Porto, Elisardo Corral Vasquez, Silvana Santos Meyrelles, Agata Lages Gava, Thiago Melo Costa Pereira

Affiliations

  1. 1 Physiological Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil.
  2. 2 Pharmaceutical Sciences Graduate Program, University of Vila Velha, Vila Velha, ES, Brazil.
  3. 3 Division of Nephrology, McMaster University, Hamilton, ON, Canada.
  4. 4 Federal Institute of Education, Science and Technology, Vila Velha, ES, Brazil.

PMID: 26791539 DOI: 10.1177/0960327115626582

Abstract

Contrast-induced nephropathy (CIN) is an iatrogenic medical event in stable cardiology patients that may lead to acute renal failure. There is no current successful therapy to manage CIN. Increasing evidence in experimental models and humans has suggested that this disease is associated with renal tubular and vascular injury triggered by oxidative stress. Considering the importance of reactive oxygen species (ROS) generation in the pathogenesis of CIN, the goal of the present study was to evaluate the effects of sildenafil on CIN development. Male Wistar rats were divided into control, CIN, and CIN pretreated with sildenafil (50 mg/kg/day). CIN was induced by water deprivation, N

Keywords: Renal toxicology; contrast-induced nephropathy; kidney injury; oxidative stress; renal function; sildenafil

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