Display options
Cite
Roncero C, Palma-Álvarez RF, Ros-Cucurull E, et al. Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases. Clin Psychopharmacol Neurosci. 2016;14(1):109-13doi: 10.9758/cpn.2016.14.1.109.
Roncero, C., Palma-Álvarez, R. F., Ros-Cucurull, E., Barral, C., Gonzalvo, B., Corominas-Roso, M., Casas, M., & Grau-López, L. (2016). Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 14(1), 109-13. https://doi.org/10.9758/cpn.2016.14.1.109
Roncero, Carlos, et al. "Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases." Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology vol. 14,1 (2016): 109-13. doi: https://doi.org/10.9758/cpn.2016.14.1.109
Roncero C, Palma-Álvarez RF, Ros-Cucurull E, Barral C, Gonzalvo B, Corominas-Roso M, Casas M, Grau-López L. Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases. Clin Psychopharmacol Neurosci. 2016 Feb 29;14(1):109-13. doi: 10.9758/cpn.2016.14.1.109. PMID: 26792050; PMCID: PMC4730925.
Copy Download .nbib Format: NLM
Share it on

Clin Psychopharmacol Neurosci. 2016 Feb 29;14(1):109-13. doi: 10.9758/cpn.2016.14.1.109.

Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Carlos Roncero, Raul Felipe Palma-Álvarez, Elena Ros-Cucurull, Carmen Barral, Begoña Gonzalvo, Margarida Corominas-Roso, Miguel Casas, Lara Grau-López

Affiliations

  1. Addictions and Dual Diagnosis Unit, Vall d'Hebron University Hospital-Public Health Agency of Barcelona (ASPB), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
  2. Department of Psychiatry, Vall d'Hebron University Hospital, CIBERSAM, Spain.
  3. Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

PMID: 26792050 PMCID: PMC4730925 DOI: 10.9758/cpn.2016.14.1.109

Abstract

Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.

Keywords: Biological marker; Brain-derived neurotrophic factor; Cocaine dependence; Psychosis; induced psychosis

References

  1. Pharmacol Ther. 2012 Apr;134(1):116-24 - PubMed
  2. Mol Psychiatry. 2014 Jul;19(7):791-800 - PubMed
  3. J Physiol Pharmacol. 2010 Oct;61(5):533-41 - PubMed
  4. Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):387-93 - PubMed
  5. Psychopharmacology (Berl). 2010 Oct;212(3):301-7 - PubMed
  6. Early Interv Psychiatry. 2012 Nov;6(4):389-98 - PubMed
  7. Eur Psychiatry. 2013 Mar;28(3):141-6 - PubMed
  8. Int J Neuropsychopharmacol. 2014 Jan;17(1):33-40 - PubMed
  9. Biol Psychiatry. 2011 Oct 15;70(8):706-11 - PubMed
  10. Neuropsychobiology. 2010;62(2):87-90 - PubMed
  11. Neuroscience. 2011 Oct 27;194:36-52 - PubMed
  12. Pharmacol Rev. 2012 Apr;64(2):238-58 - PubMed
  13. Transl Psychiatry. 2013 Jan 15;3:e207 - PubMed
  14. Neuroscience. 2014 Jun 13;270:27-39 - PubMed
  15. Neuropsychobiology. 2013;68(3):146-55 - PubMed
  16. Mol Psychiatry. 2011 Sep;16(9):960-72 - PubMed
  17. Neuropsychobiology. 2007;55(1):2-13 - PubMed
  18. Psychiatry Res. 2012 Sep 30;199(2):92-7 - PubMed
  19. Neurotoxicol Teratol. 2011 Nov-Dec;33(6):680-5 - PubMed
  20. World J Psychiatry. 2015 Mar 22;5(1):154-9 - PubMed
  21. Actas Esp Psiquiatr. 2012 Jul-Aug;40(4):187-97 - PubMed
  22. Mol Psychiatry. 2015 Sep;20(9):1108-19 - PubMed
  23. Clin Psychopharmacol Neurosci. 2012 Aug;10(2):61-70 - PubMed
  24. Front Psychiatry. 2013 Jun 17;4:45 - PubMed
  25. Eur Neuropsychopharmacol. 2013 Sep;23(9):1078-84 - PubMed

Publication Types