Display options
Cite
Daikuhara S, Uehara T, Higuchi K, et al. Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine. Acta Histochem Cytochem. 2015;48(6):193-204doi: 10.1267/ahc.15021.
Daikuhara, S., Uehara, T., Higuchi, K., Hosaka, N., Iwaya, M., Maruyama, Y., Matsuda, K., Arakura, N., Tanaka, E., & Ota, H. (2015). Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine. Acta histochemica et cytochemica, 48(6), 193-204. https://doi.org/10.1267/ahc.15021
Daikuhara, Seiichi, et al. "Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine." Acta histochemica et cytochemica vol. 48,6 (2015): 193-204. doi: https://doi.org/10.1267/ahc.15021
Daikuhara S, Uehara T, Higuchi K, Hosaka N, Iwaya M, Maruyama Y, Matsuda K, Arakura N, Tanaka E, Ota H. Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine. Acta Histochem Cytochem. 2015 Dec 25;48(6):193-204. doi: 10.1267/ahc.15021. Epub 2015 Dec 18. PMID: 26855452; PMCID: PMC4731852.
Copy Download .nbib Format: NLM
Share it on

Acta Histochem Cytochem. 2015 Dec 25;48(6):193-204. doi: 10.1267/ahc.15021. Epub 2015 Dec 18.

Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) as a Useful Immunohistochemical Marker for the Diagnosis of Adenocarcinoma of Small Intestine.

Acta histochemica et cytochemica

Seiichi Daikuhara, Takeshi Uehara, Kayoko Higuchi, Noriko Hosaka, Mai Iwaya, Yasuhiro Maruyama, Kazuyuki Matsuda, Norikazu Arakura, Eiji Tanaka, Hiroyoshi Ota

Affiliations

  1. Department of Gastroenterology, Shinshu University School of Medicine , 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
  2. Department of Laboratory Medicine, Shinshu University School of Medicine , 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
  3. Department of Clinical Laboratory, Aizawa Hospital , 2-5-1 Honjou, Matsumoto, Nagano 390-8510, Japan.
  4. Department of Laboratory Medicine, Nagano Municipal Hospital , 1333-1 Tomitake.
  5. Department of Pathology, Nagano Municipal Hospital , 1333-1 Tomitake, Nagano 381-8551, Japan.
  6. Department of Laboratory Medicine, Shinshu University Hospital , Matsumoto, Nagano 390-8621, Japan.
  7. Endoscopic Examination Center, Shinshu University Hospital , Matsumoto, Nagano 390-8621, Japan.
  8. Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University School of Medicine , 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

PMID: 26855452 PMCID: PMC4731852 DOI: 10.1267/ahc.15021

Abstract

The biological characteristics and roles of insulin-like growth factor II mRNA-binding protein 3 protein (IMP3) expression in small-intestinal adenocarcinoma were investigated. The value of IMP3 immunostaining in the diagnosis of small-intestinal epithelial lesions was also evaluated. Immunohistochemical expression of IMP3 in normal small-intestinal mucosa adjacent to adenoma and adenocarcinoma lesions, and inflamed duodenal and ileal mucosa was analyzed. Samples assessed were: duodenal ulcer (n=6), Crohn's disease (n=5), low-grade small-intestinal adenoma (n=10), high-grade small-intestinal adenoma (n=13), small-intestinal adenocarcinoma (n=23), lymph node metastases (LNM; n=7), and preoperative biopsies of small-intestinal adenocarcinoma (n=6). Immunohistochemical expression of Ki-67 and p53 was also analyzed in adenoma and adenocarcinoma samples. IMP3 was not expressed in normal epithelium, but weakly expressed in reparative epithelium. Meanwhile, increased IMP3 expression was associated with a higher degree of dysplasia in adenomas, higher T classification, LNM, Ki-67 positivity, histological differentiation, and lower 5-year disease-free survival, but not p53 expression in adenocarcinoma. IMP3 expression appears to be a late event in the small-intestinal carcinogenesis. Assessing the IMP3 staining pattern can be useful in the diagnosis of small-intestinal epithelial lesions when used in conjunction with other histological criteria.

Keywords: IMP3; adenocarcinoma; immunohistochemistry; p53; small intestine

References

  1. Clin Cancer Res. 2008 Mar 15;14(6):1701-6 - PubMed
  2. J Clin Pathol. 2003 Dec;56(12):898-903 - PubMed
  3. Hum Pathol. 2013 Aug;44(8):1508-15 - PubMed
  4. Cancer. 1990 Aug 15;66(4):702-15 - PubMed
  5. Gastroenterology. 1997 Jul;113(1):127-35 - PubMed
  6. Hum Pathol. 2009 Oct;40(10):1377-83 - PubMed
  7. Hum Pathol. 2010 Apr;41(4):477-84 - PubMed
  8. Am J Clin Pathol. 2009 Dec;132(6):877-82 - PubMed
  9. Am J Surg Pathol. 2008 Feb;32(2):304-15 - PubMed
  10. Mol Cell Biol. 1999 Feb;19(2):1262-70 - PubMed
  11. Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1101-5 - PubMed
  12. Br J Surg. 2009 Jan;96(1):66-73 - PubMed
  13. J Am Coll Surg. 1995 Aug;181(2):145-54 - PubMed
  14. J Biol Chem. 2011 Jul 22;286(29):25882-90 - PubMed
  15. Oncol Rep. 2002 Mar-Apr;9(2):293-300 - PubMed
  16. Exp Mol Pathol. 2014 Feb;96(1):48-53 - PubMed
  17. Int J Cancer. 1997 Feb 7;70(4):390-5 - PubMed
  18. J Surg Oncol. 2012 Jun 15;105(8):780-5 - PubMed
  19. Dig Liver Dis. 2014 Feb;46(2):97-104 - PubMed
  20. Clin Endocrinol (Oxf). 2014 Jun;80(6):773-81 - PubMed
  21. Lancet Oncol. 2006 Jul;7(7):556-64 - PubMed
  22. Am J Surg Pathol. 2009 Apr;33(4):521-5 - PubMed
  23. J Biol Chem. 2005 May 6;280(18):18517-24 - PubMed
  24. EMBO J. 2006 Apr 5;25(7):1456-68 - PubMed
  25. Cell Death Dis. 2014 Jan 23;5:e1025 - PubMed
  26. Oncogene. 1997 Jun 5;14(22):2729-33 - PubMed
  27. Mech Dev. 1999 Oct;88(1):95-9 - PubMed
  28. Chin Med J (Engl). 2010 Dec;123(24):3554-8 - PubMed
  29. BMC Cancer. 2010 Feb 23;10:59 - PubMed
  30. Ann Surg Oncol. 2009 Dec;16(12):3499-506 - PubMed
  31. Stain Technol. 1986 Jul;61(4):235-8 - PubMed
  32. Cancer. 1988 Jan 15;61(2):316-23 - PubMed
  33. Diagn Pathol. 2012 Nov 28;7:165 - PubMed
  34. Hum Pathol. 2009 Dec;40(12):1699-705 - PubMed
  35. Gut. 2002 Feb;50(2):218-23 - PubMed
  36. Am J Surg Pathol. 2005 Feb;29(2):188-95 - PubMed
  37. Ann Oncol. 2012 Jul;23(7):1894-8 - PubMed
  38. Acta Histochem Cytochem. 2014 May 1;47(2):45-57 - PubMed
  39. Nat Rev Clin Oncol. 2013 Sep;10(9):534-44 - PubMed
  40. J Biol Chem. 1996 May 10;271(19):11477-83 - PubMed

Publication Types