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Tancredi A, Muscarella LA, la Torre A, et al. The Post-Surgical Long-Term Behaviour of Lung Carcinoid Tumours. Indian J Surg. 2015;77(6):481-5doi: 10.1007/s12262-015-1290-z.
Tancredi, A., Muscarella, L. A., la Torre, A., Scaramuzzi, R., Valori, V. M., Fazio, V. M., & Scaramuzzi, G. (2015). The Post-Surgical Long-Term Behaviour of Lung Carcinoid Tumours. The Indian journal of surgery, 77(6), 481-5. https://doi.org/10.1007/s12262-015-1290-z
Tancredi, Antonio, et al. "The Post-Surgical Long-Term Behaviour of Lung Carcinoid Tumours." The Indian journal of surgery vol. 77,6 (2015): 481-5. doi: https://doi.org/10.1007/s12262-015-1290-z
Tancredi A, Muscarella LA, la Torre A, Scaramuzzi R, Valori VM, Fazio VM, Scaramuzzi G. The Post-Surgical Long-Term Behaviour of Lung Carcinoid Tumours. Indian J Surg. 2015 Dec;77(6):481-5. doi: 10.1007/s12262-015-1290-z. Epub 2015 May 31. PMID: 26884654; PMCID: PMC4744214.
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Indian J Surg. 2015 Dec;77(6):481-5. doi: 10.1007/s12262-015-1290-z. Epub 2015 May 31.

The Post-Surgical Long-Term Behaviour of Lung Carcinoid Tumours.

The Indian journal of surgery

Antonio Tancredi, Lucia Anna Muscarella, Annamaria la Torre, Roberto Scaramuzzi, Vanna Maria Valori, Vito Michele Fazio, Gerardo Scaramuzzi

Affiliations

  1. Unit of General Surgery 2nd and Thoracic Surgery, IRCCS "Casa Sollievo della Sofferenza" Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo Foggia, Italy ; Azienda Sanitaria Locale di Foggia, Unit of General Surgery, "San Camillo De Lellis" Hospital, Via Isonzo, 71043 Manfredonia Foggia, Italy.
  2. Laboratory of Oncology, IRCCS "Casa Sollievo della Sofferenza" Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo Foggia, Italy.
  3. Unit of General Surgery 2nd and Thoracic Surgery, IRCCS "Casa Sollievo della Sofferenza" Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo Foggia, Italy.
  4. Unit of Oncology, IRCCS "Casa Sollievo della Sofferenza" Hospital, Viale Cappuccini 1, 71013 San Giovanni Rotondo Foggia, Italy.

PMID: 26884654 PMCID: PMC4744214 DOI: 10.1007/s12262-015-1290-z

Abstract

Here, we report a retrospective evaluation of long-term behaviour of lung carcinoids after surgery. A total of 23 patients (17 with typical pulmonary carcinoids and 6 with atypical pulmonary carcinoids) were enrolled in our hospital from April 1994 to July 2009. All patients underwent intervention at the Unit of Surgery and then were followed at the Unit of Oncology. The standard protocol for patient monitoring consisted of follow-up at 3 months after surgery, 6 months after first control and annually for 5 years. The follow-up evaluations consisted in blood tests, imaging of chest and abdomen, bone scintigraphy, and brain computed tomography. In case of disease recurrence, patients underwent chemotherapy (etoposide, carboplatin) and radiotherapy. All patients were followed for a mean of follow-up period of 100 months, ranging between 20 and 203 months. In the group of typical carcinoid, the observed recurrence rate at 5 years was zero, at 10 years was 5.8 %, whereas the observed mortality rate at 5 and 10 years was zero. In the group of atypical carcinoid, both the recurrence rate and the mortality rate at 5 and 10 years were 16.6 %. A statistical significant difference (p = 0.002) in the recurrence rate between stage I and stage II was observed. The overall prognosis of pulmonary carcinoids was favourable, and the typical carcinoids presented a better prognosis than the atypical ones. The stage at time of diagnosis could be considered as a predictive prognostic factor.

Keywords: Carcinoid tumours; Long term follow-up; Lung cancer; Lymph node metastasis; Tumour behaviour

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