Display options
Cite
Meng B, Li SM, Yang Y, et al. The association of TGFB1 genetic polymorphisms with high myopia: a systematic review and meta-analysis. Int J Clin Exp Med. 2015;8(11):20355-67
Meng, B., Li, S. M., Yang, Y., Yang, Z. R., Sun, F., Kang, M. T., Sun, Y. Y., Ran, A. R., Wang, J. N., Yan, R., BaI, Y. W., Wang, N. L., & Zhan, S. Y. (2015). The association of TGFB1 genetic polymorphisms with high myopia: a systematic review and meta-analysis. International journal of clinical and experimental medicine, 8(11), 20355-67.
Meng, Bo, et al. "The association of TGFB1 genetic polymorphisms with high myopia: a systematic review and meta-analysis." International journal of clinical and experimental medicine vol. 8,11 (2015): 20355-67.
Meng B, Li SM, Yang Y, Yang ZR, Sun F, Kang MT, Sun YY, Ran AR, Wang JN, Yan R, BaI YW, Wang NL, Zhan SY. The association of TGFB1 genetic polymorphisms with high myopia: a systematic review and meta-analysis. Int J Clin Exp Med. 2015 Nov 15;8(11):20355-67. eCollection 2015. PMID: 26884952; PMCID: PMC4723797.
Copy Download .nbib Format: NLM
Share it on

Int J Clin Exp Med. 2015 Nov 15;8(11):20355-67. eCollection 2015.

The association of TGFB1 genetic polymorphisms with high myopia: a systematic review and meta-analysis.

International journal of clinical and experimental medicine

Bo Meng, Shi-Ming Li, Yu Yang, Zhi-Rong Yang, Feng Sun, Meng-Tian Kang, Yun-Yun Sun, An-Ran Ran, Jia-Nan Wang, Ran Yan, Ya-Wen BaI, Ning-Li Wang, Si-Yan Zhan

Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science CentreBeijing 100191, China; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityBeijing 100005, China.
  2. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University Beijing 100005, China.
  3. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre Beijing 100191, China.

PMID: 26884952 PMCID: PMC4723797

Abstract

OBJECTIVE: The TGFB1 gene is among the most studied genes in high myopia due to its role in scleral remodeling. But reported findings of association on TGFB1 and high myopia are inconsistent. This present study is to evaluate the association of TGFB1 polymorphisms and high myopia.

METHODS: A comprehensive literature search was conducted on studies published up to April 5, 2015. Summary odds ratios (ORs) and 95% confidence intervals were analyzed. Heterogeneity across studies was evaluated by Cochran Q statistic test and the I(2) index. Sensitivity analyses were conducted by the approach of one-study remove to assess the influence of single study on the combined effect.

RESULTS: Eight studies were included in this study for meta-analysis. Rs1982073 was associated with high myopia in dominant model (OR=1.64; 95% CI=1.04~2.58; P<0.05), heterozygous model (OR=1.54; 95% CI=1.02~2.33; P<0.05), homozygous model (OR=1.90; 95% CI=1.01~3.55; P=0.05) and allelic model (OR=1.36; 95% CI=1.01~1.84; P=0.05). However, there was no statistical significance when Bonferroni correction was considered. Rs4803455 was associated with high myopia in recessive model (OR=0.40; 95% CI=0.25~0.64; P<0.01) and homozygous model (OR=0.42; 95% CI=0.26~0.68; P<0.01). Rs1800469 was associated with high myopia in allelic model (OR=0.78; 95% CI=0.64~0.96; P<0.05). And the associations can withstand Bonferroni correction in models mentioned above when referring to rs4803455 (P<0.01) and rs1800469 (P<0.05).

CONCLUSIONS: Meta-analysis of existing data revealed a suggestive association of TGFB1 rs1982073 and rs4803455 with high myopia.

Keywords: Transforming growth factor beta1; high myopia; single nucleotide polymorphism

References

  1. Nat Genet. 2001 Oct;29(2):117-29 - PubMed
  2. J Natl Cancer Inst. 2002 May 15;94(10):755-61 - PubMed
  3. Am J Epidemiol. 2002 Aug 15;156(4):300-10 - PubMed
  4. J Biol Chem. 2004 Apr 30;279(18):18121-6 - PubMed
  5. J Clin Invest. 2004 Mar;113(5):676-85 - PubMed
  6. Ann Acad Med Singapore. 2004 Jan;33(1):27-33 - PubMed
  7. Am J Hum Genet. 2004 Aug;75(2):294-304 - PubMed
  8. Mol Vis. 2005 Jul 22;11:554-60 - PubMed
  9. Ophthalmic Physiol Opt. 2005 Sep;25(5):381-91 - PubMed
  10. Ophthalmology. 2005 Dec;112(12):2103-9 - PubMed
  11. Hum Genet. 2006 May;119(4):389-99 - PubMed
  12. J Med Genet. 2006 May;43(5):e20 - PubMed
  13. Mol Vis. 2006 Jun 21;12:698-703 - PubMed
  14. Jpn J Ophthalmol. 2007 Mar-Apr;51(2):96-9 - PubMed
  15. Science. 2007 Jul 13;317(5835):256-60 - PubMed
  16. Nat Med. 2007 Aug;13(8):952-61 - PubMed
  17. Clin Exp Optom. 2008 Jan;91(1):4-22 - PubMed
  18. Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3768-78 - PubMed
  19. J Biol Chem. 2009 Jan 23;284(4):2072-9 - PubMed
  20. Exp Eye Res. 2009 Mar;88(3):458-66 - PubMed
  21. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1546-51 - PubMed
  22. Mol Vis. 2008;14:2566-74 - PubMed
  23. Arch Ophthalmol. 2009 Apr;127(4):541-8 - PubMed
  24. Curr Opin Ophthalmol. 2009 Sep;20(5):356-62 - PubMed
  25. PLoS Genet. 2009 Sep;5(9):e1000660 - PubMed
  26. Clin Genet. 1990 Oct;38(4):281-6 - PubMed
  27. Arch Ophthalmol. 2010 Aug;128(8):1081-4 - PubMed
  28. Nat Genet. 2010 Oct;42(10):902-5 - PubMed
  29. Nat Genet. 2010 Oct;42(10):897-901 - PubMed
  30. Lancet. 2012 May 5;379(9827):1739-48 - PubMed
  31. Biochem Genet. 2013 Apr;51(3-4):323-33 - PubMed
  32. Genomics Inform. 2012 Dec;10(4):256-62 - PubMed
  33. Nat Genet. 2013 Mar;45(3):314-8 - PubMed
  34. Exp Eye Res. 2013 Sep;114:128-40 - PubMed
  35. Clin Genet. 2013 Aug;84(2):102-8 - PubMed
  36. Curr Eye Res. 2014 Mar;39(3):282-90 - PubMed
  37. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4167-71 - PubMed
  38. Gene. 2014 Jan 15;534(1):10-6 - PubMed
  39. Invest Ophthalmol Vis Sci. 2014 May 29;55(5):3344-51 - PubMed
  40. Curr Opin Ophthalmol. 2014 Sep;25(5):386-93 - PubMed
  41. Mol Vis. 2014 Jul 02;20:977-87 - PubMed
  42. Mol Vis. 2014 Dec 09;20:1643-59 - PubMed
  43. PLoS One. 2015 Mar 30;10(3):e0119779 - PubMed
  44. Somat Cell Mol Genet. 1986 May;12(3):281-8 - PubMed
  45. Nature. 1985 Aug 22-28;316(6030):701-5 - PubMed
  46. Am J Hum Genet. 1998 Nov;63(5):1419-24 - PubMed
  47. Transplantation. 1998 Oct 27;66(8):1014-20 - PubMed

Publication Types