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Chen QL, Dwa S, Gong ZC, et al. Kimura's disease: risk factors of recurrence and prognosis. Int J Clin Exp Med. 2015;8(11):21414-20
Chen, Q. L., Dwa, S., Gong, Z. C., Abasi, K., Ling, B., Liu, H., Hu, L. L., Shao, B., & Lin, Z. Q. (2015). Kimura's disease: risk factors of recurrence and prognosis. International journal of clinical and experimental medicine, 8(11), 21414-20.
Chen, Qing-Li, et al. "Kimura's disease: risk factors of recurrence and prognosis." International journal of clinical and experimental medicine vol. 8,11 (2015): 21414-20.
Chen QL, Dwa S, Gong ZC, Abasi K, Ling B, Liu H, Hu LL, Shao B, Lin ZQ. Kimura's disease: risk factors of recurrence and prognosis. Int J Clin Exp Med. 2015 Nov 15;8(11):21414-20. eCollection 2015. PMID: 26885085; PMCID: PMC4723930.
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Int J Clin Exp Med. 2015 Nov 15;8(11):21414-20. eCollection 2015.

Kimura's disease: risk factors of recurrence and prognosis.

International journal of clinical and experimental medicine

Qing-Li Chen, Srijana Dwa, Zhong-Cheng Gong, Keremu Abasi, Bin Ling, Hui Liu, Lu-Lu Hu, Bo Shao, Zhao-Quan Lin

Affiliations

  1. Oncology Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Province China.

PMID: 26885085 PMCID: PMC4723930

Abstract

OBJECTIVES: The aim of this study was to evaluate risk factors for recurrence and prognosis of Kimura's disease.

METHODS: In this study, 32 patients received surgery alone, surgery followed by steroids orally and surgery followed by radiotherapy respectively from 2003 to 2015 (male/female: 27/5, ages: 6-64 years). Retrieval of clinical data and follow-ups have been done. The clinical features used as variables include age, gender, location, multiplicity, laterality, size, duration, primary outbreak, smoking, eosinophils, systemic disease and remedies. Statistical analysis including Kaplan-Meier method, Fisher's exact test, Kruskal-Wallis H test, Mann-Whitney U-test and Cox proportional hazard regression model were performed with the SPSS 17.0. The threshold of statistical significance was set at P=0.05.

RESULTS: Median recurrence time was 29 months (2.42 years) after discharged and 56.3% patients relapsed. High recurrence rate was significantly associated with smoking habit (P=0.036). Patients who were diagnosed systemic disease (P=0.027) and were treated with surgery alone (P=0.025) or surgery followed by steroids orally (P=0.025) had short disease-free time. Furthermore, smoking habit (HR=3.383, 95% CI: 1.213-9.433, P=0.02), systemic disease (HR=4.462, 95% CI: 1.443-13.794, P=0.009), surgery alone (HR=4.668, 95% CI: 1.506-14.470, P=0.008) and surgery followed by steroids orally (HR=6.053, 95% CI: 1.330-27.556, P=0.02) were identified as risk factors for the prognosis of Kimura's disease.

CONCLUSIONS: Smoking habit, systemic diseases, surgery alone and surgery followed by steroids orally were associated with poor prognosis of Kimura's disease, and they might be prognostic markers of Kimura's disease.

Keywords: Kimura’s disease; prognosis; radiotherapy; recurrence; smoking

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