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Ilkhanizadeh B, Shirpoor A, Khadem Ansari MH, et al. Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats. Diabetes Metab J. 2016;40(1):46-53doi: 10.4093/dmj.2016.40.1.46.
Ilkhanizadeh, B., Shirpoor, A., Khadem Ansari, M. H., Nemati, S., & Rasmi, Y. (2016). Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats. Diabetes & metabolism journal, 40(1), 46-53. https://doi.org/10.4093/dmj.2016.40.1.46
Ilkhanizadeh, Behrouz, et al. "Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats." Diabetes & metabolism journal vol. 40,1 (2016): 46-53. doi: https://doi.org/10.4093/dmj.2016.40.1.46
Ilkhanizadeh B, Shirpoor A, Khadem Ansari MH, Nemati S, Rasmi Y. Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats. Diabetes Metab J. 2016 Feb;40(1):46-53. doi: 10.4093/dmj.2016.40.1.46. PMID: 26912155; PMCID: PMC4768050.
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Diabetes Metab J. 2016 Feb;40(1):46-53. doi: 10.4093/dmj.2016.40.1.46.

Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats.

Diabetes & metabolism journal

Behrouz Ilkhanizadeh, Alireza Shirpoor, Mohamad Hasan Khadem Ansari, Samira Nemati, Yusef Rasmi

Affiliations

  1. Department of Pathology, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.
  2. Department of Physiology, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran. [email protected].
  3. Department of Biochemistry, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.
  4. Department of Physiology, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.

PMID: 26912155 PMCID: PMC4768050 DOI: 10.4093/dmj.2016.40.1.46

Abstract

BACKGROUND: Diabetic cardiomyopathy is an important causal factor in morbidity and mortality among diabetic patients, and currently, no effective means are available to reverse its pathological progress. The purpose of the present study was to investigate the effect of ginger extract on apolipoproteins (apo) A and B, hyperhomocysteinemia, cathepsin G and leptin changes, as well as cardiac fibrosis and heart muscle cell proliferation under hyperglycemic conditions in vivo.

METHODS: Twenty-four male Wistar rats were divided into three groups, namely: control, non-treated diabetic, and ginger extract-treated diabetic groups. The ginger extract-treated diabetic group received a 50 mg daily dose of ginger extract intragastrically for 6 weeks.

RESULTS: The results revealed concurrent significant increases in plasma C-reactive protein (CRP), homocysteine (Hcy), cathepsin G and apoB levels and decreases in apoA and leptin levels in the non-treated diabetic group compared to the control group. Moreover, heart structural changes, including fibrosis and heart muscle cell proliferation, were observed in non-treated diabetic rats compared to the control rats. Significant amelioration of changes in the heart structure together with restoration of the elevated levels of Hcy and CRP, leptin, cathepsin G, and apoA and B were found in the ginger extract-treated diabetic group compared to the non-treated diabetic group.

CONCLUSION: The findings indicated that ginger extract significantly reduces heart structural abnormalities in diabetic rats and that these effects might be associated with improvements in serum apo, leptin, cathepsin G, and Hcy levels and with the antioxidant properties of ginger extract.

Keywords: Diabetes; Ginger; Heart; Leptin; Rats

References

  1. Diabetes. 1996 Oct;45(10):1364-6 - PubMed
  2. J Biol Chem. 1982 Aug 10;257(15):8619-22 - PubMed
  3. Int Immunopharmacol. 2015 May;26(1):72-9 - PubMed
  4. Diabetes. 2010 Jul;59(7):1626-34 - PubMed
  5. Cerebrovasc Dis. 2003;15(1-2):63-9 - PubMed
  6. Med Hypotheses. 1992 Dec;39(4):342-8 - PubMed
  7. Physiol Behav. 2004 Apr;81(2):223-41 - PubMed
  8. J Biol Chem. 2009 Oct 2;284(40):27090-100 - PubMed
  9. Diabetes. 1996 May;45(5):699-701 - PubMed
  10. World J Diabetes. 2014 Dec 15;5(6):860-7 - PubMed
  11. J Intern Med. 2006 May;259(5):437-46 - PubMed
  12. Cardiovasc Toxicol. 2011 Dec;11(4):325-33 - PubMed
  13. Atherosclerosis. 2011 Aug;217(2):503-8 - PubMed
  14. Peptides. 2008 Jan;29(1):127-38 - PubMed
  15. Circ Res. 2003 Aug 22;93(4):277-9 - PubMed
  16. Nature. 2010 Apr 29;464(7293):1293-300 - PubMed
  17. Clin Exp Pharmacol Physiol. 2011 Dec;38(12):905-13 - PubMed
  18. J Nutr Biochem. 2013 Dec;24(12):2110-8 - PubMed
  19. Nat Rev Cardiol. 2010 Jan;7(1):22-9 - PubMed
  20. Physiol Rev. 2008 Apr;88(2):389-419 - PubMed
  21. Cardiovasc Res. 2011 Jan 1;89(1):60-71 - PubMed
  22. Endocrinology. 2010 Mar;151(3):1010-8 - PubMed
  23. Biochem Biophys Res Commun. 2008 Aug 29;373(3):429-34 - PubMed
  24. J Clin Pathol. 1988 Apr;41(4):467-70 - PubMed
  25. Int Immunopharmacol. 2013 Aug;16(4):498-504 - PubMed
  26. J Intern Med. 2006 May;259(5):493-519 - PubMed
  27. Diabetes. 2000 Feb;49(2):293-7 - PubMed
  28. J Diabetes Complications. 2009 Sep-Oct;23(5):310-6 - PubMed
  29. Trends Cardiovasc Med. 2008 Aug;18(6):199-205 - PubMed
  30. J Am Coll Cardiol. 2011 Oct 25;58(18):1870-7 - PubMed
  31. Clin Chim Acta. 2015 Mar 30;443:29-38 - PubMed
  32. J Surg Res. 2007 Jun 15;140(2):199-203 - PubMed
  33. Diabetes. 2007 Mar;56(3):641-6 - PubMed
  34. Diabetes. 2002 Jan;51(1):168-73 - PubMed
  35. Circ Res. 2006 Mar 17;98(5):596-605 - PubMed
  36. J Ren Nutr. 2011 May;21(3):263-70 - PubMed
  37. J Biol Chem. 2004 Nov 26;279(48):49704-15 - PubMed
  38. Respir Physiol Neurobiol. 2013 Feb 1;185(3):593-9 - PubMed
  39. J Clin Invest. 1997 Sep 1;100(5):1107-13 - PubMed
  40. J Diabetes. 2012 Dec;4(4):362-8 - PubMed

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