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Chin Med. 2016 Feb 24;11:6. doi: 10.1186/s13020-016-0075-z. eCollection 2016.

Chinese medicines in the treatment of experimental diabetic nephropathy.

Chinese medicine

Jing-Yi Liu, Xiao-Xin Chen, Sydney Chi-Wai Tang, Stephen Cho-Wing Sze, Yi-Bin Feng, Kai-Fai Lee, Kalin Yan-Bo Zhang

Affiliations

  1. School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Hong Kong, People's Republic of China.
  2. Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Hong Kong, People's Republic of China.
  3. Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Hong Kong, People's Republic of China.

PMID: 26913057 PMCID: PMC4765093 DOI: 10.1186/s13020-016-0075-z

Abstract

Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is complicated, and effective and safe therapeutic strategies are desired. While the complex nature of DN renders medicines with a single therapeutic target less efficacious, Chinese medicine, with its holistic view targeting the whole system of the patient, has exhibited efficacy for DN management. This review aims to describe the experimental evidence for Chinese medicines in DN management, with an emphasis on the underlying mechanisms, and to discuss the combined use of herbs and drugs in DN treatment.

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