Display options
Cite
Verhulst J. Hyperthermic intraperitoneal chemoperfusion with high dose oxaliplatin: Influence of perfusion temperature on postoperative outcome and survival. F1000Res. 2013;2:179doi: 10.12688/f1000research.2-179.v1.
Verhulst, J. (2013). Hyperthermic intraperitoneal chemoperfusion with high dose oxaliplatin: Influence of perfusion temperature on postoperative outcome and survival. F1000Research, 2179. https://doi.org/10.12688/f1000research.2-179.v1
Verhulst, Johanna. "Hyperthermic intraperitoneal chemoperfusion with high dose oxaliplatin: Influence of perfusion temperature on postoperative outcome and survival." F1000Research vol. 2 (2013): 179. doi: https://doi.org/10.12688/f1000research.2-179.v1
Verhulst J. Hyperthermic intraperitoneal chemoperfusion with high dose oxaliplatin: Influence of perfusion temperature on postoperative outcome and survival. F1000Res. 2013 Sep 03;2:179. doi: 10.12688/f1000research.2-179.v1. eCollection 2013. PMID: 26913184.
Copy Download .nbib Format: NLM
Share it on

F1000Res. 2013 Sep 03;2:179. doi: 10.12688/f1000research.2-179.v1. eCollection 2013.

Hyperthermic intraperitoneal chemoperfusion with high dose oxaliplatin: Influence of perfusion temperature on postoperative outcome and survival.

F1000Research

Johanna Verhulst

Affiliations

  1. Independent Researcher, Karel Oomsstraat 57, Antwerpen, 2018, Belgium.

PMID: 26913184 DOI: 10.12688/f1000research.2-179.v1

Abstract

UNLABELLED: Introduction : Hyperthermic intraperitoneal chemotherapy (HIPEC) is becoming a standard therapy in the treatment of peritoneal carcinomatosis (PC). Compared to systemic chemotherapy, HIPEC improves survival in patients with PC. This therapy has high morbidity rates (up to 41%). In vitro it has been demonstrated that hyperthermia has a toxic effect on malign cells. However, hyperthermia also affects normal tissue. To my knowledge, any additional effect of hyperthermia combined with chemotherapy has never been demonstrated in a clinical setting. In this study, the effects of hyperthermia on outcome and survival were analyzed. Methods : Patients with PC from any origin who were treated with HIPEC were included in this retrospective, non-randomized study. Data on patient characteristics, tumor characteristics, features of the surgery and postoperative complications were extracted from patient files. Models predicting time to removal of nasogastric tube (TRNT), post-operative major complications, the occurrence of anastomotic leaks and post-operative survival were built, using negative binomial regression, logistic regression or Cox proportional hazards regression as appropriate.

RESULTS: 138 patients treated with HIPEC were included. Maximal temperature during the operation was not statistically significantly associated with anastomotic leaks or post-operative major complications. Maximal temperature during the operation was negatively associated with post-operative survival (P=0.01). Conclusion : The results suggest that hyperthermia may negatively affect survival in patients who are treated with HIPEC for PC of various origins. This study has the classical limitations of a retrospective study. Therefore, randomized trials are required to confirm the results.

Publication Types