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Baker Bechmann M, Rotoli D, Morales M, et al. Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases. Front Physiol. 2016;7:9doi: 10.3389/fphys.2016.00009.
Baker Bechmann, M., Rotoli, D., Morales, M., Maeso, M. d. e. l. . C., García, M. d. e. l. . P., Ávila, J., Mobasheri, A., & Martín-Vasallo, P. (2016). Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases. Frontiers in physiology, 79. https://doi.org/10.3389/fphys.2016.00009
Baker Bechmann, Marc, et al. "Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases." Frontiers in physiology vol. 7 (2016): 9. doi: https://doi.org/10.3389/fphys.2016.00009
Baker Bechmann M, Rotoli D, Morales M, Maeso Mdel C, García Mdel P, Ávila J, Mobasheri A, Martín-Vasallo P. Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases. Front Physiol. 2016 Jan 29;7:9. doi: 10.3389/fphys.2016.00009. eCollection 2016. PMID: 26858653; PMCID: PMC4731494.
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Front Physiol. 2016 Jan 29;7:9. doi: 10.3389/fphys.2016.00009. eCollection 2016.

Na,K-ATPase Isozymes in Colorectal Cancer and Liver Metastases.

Frontiers in physiology

Marc Baker Bechmann, Deborah Rotoli, Manuel Morales, María Del Carmen Maeso, María Del Pino García, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Affiliations

  1. Laboratorio de Biología del Desarrollo, UD de Bioquímica y Biología Molecular and Centro de Investigaciones Biomédicas de Canarias, Universidad de La Laguna Santa Cruz de Tenerife, Spain.
  2. Laboratorio de Biología del Desarrollo, UD de Bioquímica y Biología Molecular and Centro de Investigaciones Biomédicas de Canarias, Universidad de La LagunaSanta Cruz de Tenerife, Spain; Institute of Endocrinology and Experimental Oncology, National Research CouncilNaples, Italy.
  3. Service of Medical Oncology, University Hospital Nuestra Señora de CandelariaSanta Cruz de Tenerife, Spain; Medical Oncology, Hospiten HospitalsSanta Cruz de Tenerife, Spain.
  4. Service of Pathology, University Hospital Nuestra Señora de Candelaria Santa Cruz de Tenerife, Spain.
  5. Department of Pathology, Hospiten Hospitals Santa Cruz de Tenerife, Spain.
  6. Department of Veterinary Preclinical Sciences, Faculty of Health and Medical Sciences, University of SurreyGuildford, UK; Faculty of Applied Medical Sciences, Center of Excellence in Genomic Medicine Research, King Fahd Medical Research Center, King AbdulAziz UniversityJeddah, Saudi Arabia.

PMID: 26858653 PMCID: PMC4731494 DOI: 10.3389/fphys.2016.00009

Abstract

The goal of this study was to define Na,K-ATPase α and β subunit isoform expression and isozyme composition in colorectal cancer cells and liver metastases. The α1, α3, and β1 isoforms were the most highly expressed in tumor cells and metastases; in the plasma membrane of non-neoplastic cells and mainly in a cytoplasmic location in tumor cells. α1β1 and α3β1 isozymes found in tumor and metastatic cells exhibit the highest and lowest Na(+) affinity respectively and the highest K(+) affinity. Mesenchymal cell isozymes possess an intermediate Na(+) affinity and a low K(+) affinity. In cancer, these ions are likely to favor optimal conditions for the function of nuclear enzymes involved in mitosis, especially a high intra-nuclear K(+) concentration. A major and striking finding of this study was that in liver, metastasized CRC cells express the α3β1 isozyme. Thus, the α3β1 isozyme could potentially serve as a novel exploratory biomarker of CRC metastatic cells in liver.

Keywords: Na/K-ATPase isoforms colorectal cancer immunohistochemistry; Na/K-ATPase isozymes; colorectal cancer; colorectal cancer liver metastases; sodium pump isozymes

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