Display options
Cite
Tezcan G, Tunca B, Ak S, et al. Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer. World J Gastrointest Oncol. 2016;8(1):83-98doi: 10.4251/wjgo.v8.i1.83.
Tezcan, G., Tunca, B., Ak, S., Cecener, G., & Egeli, U. (2016). Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer. World journal of gastrointestinal oncology, 8(1), 83-98. https://doi.org/10.4251/wjgo.v8.i1.83
Tezcan, Gulcin, et al. "Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer." World journal of gastrointestinal oncology vol. 8,1 (2016): 83-98. doi: https://doi.org/10.4251/wjgo.v8.i1.83
Tezcan G, Tunca B, Ak S, Cecener G, Egeli U. Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer. World J Gastrointest Oncol. 2016 Jan 15;8(1):83-98. doi: 10.4251/wjgo.v8.i1.83. PMID: 26798439; PMCID: PMC4714149.
Copy Download .nbib Format: NLM
Share it on

World J Gastrointest Oncol. 2016 Jan 15;8(1):83-98. doi: 10.4251/wjgo.v8.i1.83.

Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer.

World journal of gastrointestinal oncology

Gulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli

Affiliations

  1. Gulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli, Department of Medical Biology, Faculty of Medicine, Uludag University, 16059 Bursa, Turkey.

PMID: 26798439 PMCID: PMC4714149 DOI: 10.4251/wjgo.v8.i1.83

Abstract

Colorectal cancer (CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC (EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, MutYH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach.

Keywords: Clinical outcome; Colorectal cancer; Early-onset; Epigenetic mechanism; Genetic mechanism

References

  1. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6982-7 - PubMed
  2. Gastroenterology. 2001 Oct;121(4):830-8 - PubMed
  3. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5513-8 - PubMed
  4. Am J Pathol. 2001 Oct;159(4):1293-300 - PubMed
  5. Cancer Immun. 2004 Nov 25;4:14 - PubMed
  6. J Pathol. 2010 May;221(1):57-67 - PubMed
  7. Clin Genet. 2014 May;85(5):403-12 - PubMed
  8. Ann Oncol. 2013 May;24(5):1274-82 - PubMed
  9. Gut. 2000 May;46(5):656-60 - PubMed
  10. World J Gastroenterol. 2014 Dec 14;20(46):17288-96 - PubMed
  11. Gastroenterology. 2015 Jun;148(7):1427-37.e8 - PubMed
  12. Jpn J Clin Oncol. 2014 Oct;44(10):1004-8 - PubMed
  13. Hum Genet. 1996 Aug;98(2):125-8 - PubMed
  14. Am J Hum Genet. 2005 Jul;77(1):112-9 - PubMed
  15. Cancer Res. 2002 Apr 15;62(8):2261-6 - PubMed
  16. Ann Surg Oncol. 2008 Sep;15(9):2439-50 - PubMed
  17. Hum Mutat. 2005 Oct;26(4):393 - PubMed
  18. Arch Toxicol. 2015 Jun;89(6):899-921 - PubMed
  19. Int J Cancer. 2006 Feb 15;118(4):907-15 - PubMed
  20. Dig Dis Sci. 2014 Jan;59(1):64-71 - PubMed
  21. J Gastroenterol. 2008;43(6):492-7 - PubMed
  22. Nat Genet. 2002 Feb;30(2):227-32 - PubMed
  23. J Endocrinol Invest. 2010 Oct;33(9):603-6 - PubMed
  24. Lancet. 2013 Jan 26;381(9863):303-12 - PubMed
  25. Endoscopy. 2012 Sep;44 Suppl 3:SE116-30 - PubMed
  26. Clin Epigenetics. 2015 Mar 10;7:20 - PubMed
  27. Exp Mol Pathol. 2008 Dec;85(3):201-6 - PubMed
  28. J Surg Res. 2013 Dec;185(2):626-37 - PubMed
  29. Nat Commun. 2014 Oct 13;5:5191 - PubMed
  30. Gastrointest Cancer Res. 2011 Jan;4(1):15-21 - PubMed
  31. Clin Cancer Res. 2008 Jun 1;14(11):3408-15 - PubMed
  32. Histopathology. 2015 Nov;67(5):689-98 - PubMed
  33. World J Gastroenterol. 2012 Jun 14;18(22):2745-55 - PubMed
  34. Mod Pathol. 2009 Sep;22(9):1186-95 - PubMed
  35. PLoS One. 2013 Aug 12;8(8):e71755 - PubMed
  36. Mol Cancer. 2013 Jan 03;12 :1 - PubMed
  37. N Engl J Med. 2013 Sep 19;369(12):1106-14 - PubMed
  38. J Natl Cancer Inst. 2004 Nov 3;96(21):1631-4 - PubMed
  39. Cancer Res. 1999 Oct 15;59(20):5093-6 - PubMed
  40. Am Surg. 1998 Sep;64(9):849-53 - PubMed
  41. Cancer Genet. 2013 Sep-Oct;206(9-10):309-16 - PubMed
  42. World J Gastroenterol. 2010 Aug 7;16(29):3697-703 - PubMed
  43. Fam Cancer. 2006;5(3):227-35 - PubMed
  44. Cancer Res. 1997 Sep 1;57(17):3653-6 - PubMed
  45. Gastroenterology. 2006 Jan;130(1):137-49 - PubMed
  46. Med Mol Morphol. 2013 Sep;46(3):166-71 - PubMed
  47. Fam Cancer. 2011 Dec;10(4):659-65 - PubMed
  48. Am J Pathol. 1992 Feb;140(2):427-47 - PubMed
  49. Drugs Today (Barc). 2013 Feb;49(2):105-15 - PubMed
  50. World J Gastroenterol. 2009 Nov 21;15(43):5397-408 - PubMed
  51. World J Gastroenterol. 2014 Aug 21;20(31):10864-75 - PubMed
  52. Acta Oncol. 2003;42(8):809-15 - PubMed
  53. Oncogene. 2007 Jul 5;26(31):4541-9 - PubMed
  54. Clin Genet. 2013 Jul;84(1):94-6 - PubMed
  55. Clin Gastroenterol Hepatol. 2006 Apr;4(4):408-15 - PubMed
  56. Nucleic Acids Res. 2010 Jan;38(Database issue):D682-9 - PubMed
  57. Hum Mutat. 2011 Apr;32(4):407-14 - PubMed
  58. Gastroenterology. 1999 Jun;116(6):1453-6 - PubMed
  59. Cancer Res. 2002 Jul 15;62(14 ):3925-8 - PubMed
  60. Am J Gastroenterol. 2005 Oct;100(10):2280-7 - PubMed
  61. J Clin Oncol. 2009 Apr 20;27(12 ):2091-6 - PubMed
  62. Cell. 2009 May 15;137(4):623-34 - PubMed
  63. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12327-32 - PubMed
  64. J Gastrointest Surg. 1997 Mar-Apr;1(2):194-201; discussion 201-2 - PubMed
  65. Oncogene. 2002 May 9;21(20):3253-7 - PubMed
  66. Gastroenterology. 2009 Feb;136(2):471-6 - PubMed
  67. Mutat Res. 2005 Oct 15;578(1-2):430-3 - PubMed
  68. PLoS One. 2014 Aug 01;9(8):e103159 - PubMed
  69. J Natl Cancer Inst. 2004 Feb 18;96(4):261-8 - PubMed
  70. Gastroenterology. 2006 Oct;131(4):1096-109 - PubMed
  71. Surg Today. 2014 Apr;44(4):593-600 - PubMed
  72. Acta Oncol. 2014 Jul;53(7):852-64 - PubMed
  73. Eur J Cancer. 2013 Apr;49(6):1226-35 - PubMed
  74. Oncogene. 2004 Feb 19;23(7):1377-91 - PubMed
  75. Chin Clin Oncol. 2013 Jun;2(2):12 - PubMed
  76. Cancer Res. 2011 Nov 15;71(22):7010-20 - PubMed
  77. Clin Cancer Res. 2011 Oct 1;17(19):6239-49 - PubMed
  78. Nat Genet. 2009 Jan;41(1):112-7 - PubMed
  79. Int J Cancer. 1999 May 31;81(5):688-94 - PubMed
  80. PLoS One. 2015 Mar 27;10 (3):e0121980 - PubMed
  81. Genes Dis. 2015 Mar;2(1):4-12 - PubMed
  82. Arch Med Sci. 2014 Jun 29;10(3):570-7 - PubMed
  83. J Cancer Res Clin Oncol. 2013 Apr;139(4):691-702 - PubMed
  84. Am Surg. 1998 Jun;64(6):563-7; discussion 567-8 - PubMed
  85. Nat Genet. 1998 Jan;18(1):38-43 - PubMed
  86. Fam Cancer. 2011 Dec;10(4):623-31 - PubMed
  87. J Gastroenterol. 2015 Jun;50(6):657-66 - PubMed
  88. Adv Anat Pathol. 2009 Nov;16(6):405-17 - PubMed
  89. J Natl Cancer Inst Monogr. 1995;(17):5-7 - PubMed
  90. Am J Hum Genet. 1997 Dec;61(6):1327-34 - PubMed
  91. J Gastrointest Oncol. 2014 Oct;5(5):336-44 - PubMed
  92. Oncotarget. 2014 Oct 30;5(20):9889-900 - PubMed
  93. Nat Cell Biol. 2001 Apr;3(4):433-8 - PubMed
  94. N Engl J Med. 2003 Mar 6;348(10):919-32 - PubMed
  95. Nat Genet. 2009 Mar;41(3):365-70 - PubMed
  96. Mol Cancer. 2007 Aug 23;6:54 - PubMed
  97. Int J Cancer. 2013 Mar 1;132(5):1060-9 - PubMed
  98. Arch Intern Med. 2012 Feb 13;172(3):287-9 - PubMed
  99. Nat Genet. 2008 May;40(5):600-8 - PubMed
  100. N Engl J Med. 1995 Mar 30;332(13):839-47 - PubMed
  101. J Clin Oncol. 2012 Oct 1;30(28):3499-506 - PubMed
  102. Oncology. 2014;87(1):58-66 - PubMed
  103. CA Cancer J Clin. 2013 Jan;63(1):11-30 - PubMed
  104. J Mol Diagn. 2010 Jul;12(4):433-40 - PubMed
  105. Dis Colon Rectum. 2012 Mar;55(3):359-62 - PubMed
  106. Int J Cancer. 2012 Mar 1;130(5):1082-92 - PubMed
  107. Hum Mol Genet. 2002 Nov 1;11(23):2961-7 - PubMed
  108. Nat Genet. 2006 Oct;38(10):1178-83 - PubMed
  109. J Clin Oncol. 2008 Dec 10;26(35):5783-8 - PubMed
  110. J Clin Pathol. 2012 Apr;65(4):352-6 - PubMed
  111. Nat Rev Cancer. 2009 Jul;9(7):489-99 - PubMed
  112. Cancer. 2006 Sep 1;107(5 Suppl):1153-61 - PubMed
  113. J Surg Res. 2014 Sep;191(1):113-22 - PubMed
  114. N Engl J Med. 2004 Jul 22;351(4):337-45 - PubMed
  115. Science. 1995 Jun 2;268(5215):1336-8 - PubMed
  116. Fam Cancer. 2015 Sep;14 (3):415-25 - PubMed
  117. Am J Gastroenterol. 2005 Feb;100(2):476-90 - PubMed
  118. Dig Dis Sci. 2007 Mar;52(3):798-802 - PubMed
  119. Nat Med. 2003 Jan;9(1):47-52 - PubMed
  120. Oncogene. 2000 Jan 6;19(1):164-8 - PubMed
  121. J Clin Oncol. 2009 Apr 10;27(11):1814-21 - PubMed
  122. Genes Chromosomes Cancer. 2014 Oct;53(10):857-64 - PubMed
  123. Int J Cancer. 2008 Jul 15;123(2):409-13 - PubMed
  124. Mol Biol Rep. 2013 Dec;40(12):6561-8 - PubMed
  125. Neoplasma. 2007;54(2):101-7 - PubMed
  126. Cancer Res. 1998 Nov 1;58(21):4799-801 - PubMed
  127. Int J Cancer. 2002 Apr 1;98(4):498-504 - PubMed
  128. Gut. 2011 Feb;60(2):141-7 - PubMed
  129. Fam Cancer. 2011 Jun;10 (2):285-95 - PubMed
  130. Curr Biol. 2002 Jul 23;12(14):R499-R501 - PubMed
  131. J Oncol Pract. 2010 Nov;6(6):301-7 - PubMed
  132. Front Oncol. 2013 May 13;3:114 - PubMed
  133. J Clin Oncol. 2009 Aug 20;27(24):3975-80 - PubMed
  134. Am J Hum Genet. 2002 May;70(5):1357-62 - PubMed
  135. N Engl J Med. 2007 Feb 15;356(7):697-705 - PubMed
  136. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Aug;25(4):378-81 - PubMed
  137. Gastroenterology. 2010 Jun;138(6):2073-2087.e3 - PubMed
  138. Hum Mutat. 2005 Oct;26(4):291-7 - PubMed
  139. Int J Cancer. 2008 Mar 15;122(6):1422-5 - PubMed
  140. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12 ):6870-5 - PubMed
  141. Int J Cancer. 2000 May 20;89(3):230-5 - PubMed
  142. Nucleic Acids Res. 1996 Jan 1;24(1):121-4 - PubMed
  143. Hered Cancer Clin Pract. 2013 Oct 05;11(1):13 - PubMed
  144. J Mol Diagn. 2008 Jan;10(1):13-27 - PubMed
  145. Nature. 2002 Sep 12;419(6903):162-7 - PubMed
  146. Br J Cancer. 2004 Feb 9;90(3):701-4 - PubMed
  147. Cell. 2013 Nov 7;155(4):858-68 - PubMed
  148. Genes Dev. 2008 Nov 15;22(22):3172-83 - PubMed
  149. JAMA. 2005 Apr 27;293(16):1979-85 - PubMed
  150. Science. 1991 Aug 9;253(5020):661-5 - PubMed
  151. J Natl Cancer Inst. 1997 Dec 3;89(23):1758-62 - PubMed
  152. Int J Colorectal Dis. 2014 Feb;29(2):261-2 - PubMed
  153. N Engl J Med. 2003 Feb 27;348(9):791-9 - PubMed
  154. Pharmacogenetics. 2002 Jan;12(1):49-54 - PubMed
  155. N Engl J Med. 2013 Sep 19;369(12):1095-105 - PubMed
  156. Nat Cell Biol. 2001 Apr;3(4):429-32 - PubMed
  157. Mod Pathol. 2007 Dec;20(12):1253-62 - PubMed
  158. Lancet. 2004 Mar 13;363(9412):852-9 - PubMed
  159. Biochem Biophys Res Commun. 2014 Jan 17;443(3):789-95 - PubMed
  160. Gastroenterology. 2000 Dec;119(6):1447-53 - PubMed
  161. Cancer Res. 1997 Nov 15;57(22):5017-21 - PubMed
  162. Mod Pathol. 2013 Oct;26(10):1371-81 - PubMed
  163. Cancer Res. 1998 Sep 1;58(17):3787-90 - PubMed
  164. Fam Cancer. 2010 Sep;9(3):365-76 - PubMed
  165. Int J Colorectal Dis. 2008 Apr;23 (4):365-73 - PubMed
  166. Fam Cancer. 2007;6(3):301-10 - PubMed
  167. J Clin Oncol. 2007 Dec 20;25(36):5808-14 - PubMed
  168. Pathol Oncol Res. 2008 Mar;14(1):51-6 - PubMed
  169. World J Gastroenterol. 2011 Nov 28;17(44):4839-44 - PubMed
  170. Cancer Res. 2010 Apr 15;70(8):3098-108 - PubMed
  171. Am J Surg Pathol. 2015 Mar;39(3):313-7 - PubMed
  172. J Clin Oncol. 2005 Jan 20;23(3):609-18 - PubMed
  173. Clin Gastroenterol Hepatol. 2004 Feb;2(2):147-56 - PubMed
  174. Am J Surg Pathol. 2004 Jun;28(6):712-8 - PubMed

Publication Types