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Babkov DA, Paramonova MP, Ozerov AA, et al. 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors. Acta Naturae. 2015;7(4):142-5
Babkov, D. A., Paramonova, M. P., Ozerov, A. A., Khandazhinskaya, A. L., Snoeck, R., Andrei, G., & Novikov, M. S. (2015). 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors. Acta naturae, 7(4), 142-5.
Babkov, D A, et al. "2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors." Acta naturae vol. 7,4 (2015): 142-5.
Babkov DA, Paramonova MP, Ozerov AA, Khandazhinskaya AL, Snoeck R, Andrei G, Novikov MS. 2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors. Acta Naturae. 2015 Oct-Dec;7(4):142-5. PMID: 26798502; PMCID: PMC4717260.
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Acta Naturae. 2015 Oct-Dec;7(4):142-5.

2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors.

Acta naturae

D A Babkov, M P Paramonova, A A Ozerov, A L Khandazhinskaya, R Snoeck, G Andrei, M S Novikov

Affiliations

  1. Volgograd State Medical University, Pavshikh Bortsov Sq., 1, Volgograd 400131, Russia.
  2. Engelhardt Institute of Molecular Biology, Russian Academy of Science, Vavilov Str., 32, Moscow, 119991 , Russia.
  3. Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium.

PMID: 26798502 PMCID: PMC4717260

Abstract

A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (AD-169 and Davis strains) in HEL cell cultures. In addition, some of the derivatives proved to be inhibitory against varicella zoster virus.

Keywords: antiviral activity; human cytomegalovirus; synthesis; uracil derivatives

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