Display options
Cite
Madry H, Ochi M, Cucchiarini M, et al. Large animal models in experimental knee sports surgery: focus on clinical translation. J Exp Orthop. 2015;2(1):9doi: 10.1186/s40634-015-0025-1.
Madry, H., Ochi, M., Cucchiarini, M., Pape, D., & Seil, R. (2015). Large animal models in experimental knee sports surgery: focus on clinical translation. Journal of experimental orthopaedics, 2(1), 9. https://doi.org/10.1186/s40634-015-0025-1
Madry, Henning, et al. "Large animal models in experimental knee sports surgery: focus on clinical translation." Journal of experimental orthopaedics vol. 2,1 (2015): 9. doi: https://doi.org/10.1186/s40634-015-0025-1
Madry H, Ochi M, Cucchiarini M, Pape D, Seil R. Large animal models in experimental knee sports surgery: focus on clinical translation. J Exp Orthop. 2015 Dec;2(1):9. doi: 10.1186/s40634-015-0025-1. Epub 2015 Apr 15. PMID: 26914877; PMCID: PMC4545948.
Copy Download .nbib Format: NLM
Share it on

J Exp Orthop. 2015 Dec;2(1):9. doi: 10.1186/s40634-015-0025-1. Epub 2015 Apr 15.

Large animal models in experimental knee sports surgery: focus on clinical translation.

Journal of experimental orthopaedics

Henning Madry, Mitsuo Ochi, Magali Cucchiarini, Dietrich Pape, Romain Seil

Affiliations

  1. Center of Experimental Orthopaedics, Saarland University Medical Center and Saarland University, Bldg 37, Kirrbergerstr. 1, D-66421, Homburg, Germany. [email protected].
  2. Cartilage Net of the Greater Region, Homburg, Germany. [email protected].
  3. Department of Orthopaedic Surgery, Saarland University Medical Center and Saarland University, D-66421, Homburg/Saar, Germany. [email protected].
  4. Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. [email protected].
  5. Center of Experimental Orthopaedics, Saarland University Medical Center and Saarland University, Bldg 37, Kirrbergerstr. 1, D-66421, Homburg, Germany. [email protected].
  6. Cartilage Net of the Greater Region, Homburg, Germany. [email protected].
  7. Cartilage Net of the Greater Region, Homburg, Germany. [email protected].
  8. Department of Orthopaedic Surgery, Centre Hospitalier du Luxembourg, L-1460, Luxembourg, Luxembourg. [email protected].
  9. Sports Medicine Research Laboratory, Public Research Centre for Health, Luxembourg, Centre Médical de la Fondation Norbert Metz, 76 rue d'Eich, L-1460, Luxembourg, Luxembourg. [email protected].
  10. Cartilage Net of the Greater Region, Homburg, Germany. [email protected].
  11. Department of Orthopaedic Surgery, Centre Hospitalier du Luxembourg, L-1460, Luxembourg, Luxembourg. [email protected].
  12. Sports Medicine Research Laboratory, Public Research Centre for Health, Luxembourg, Centre Médical de la Fondation Norbert Metz, 76 rue d'Eich, L-1460, Luxembourg, Luxembourg. [email protected].

PMID: 26914877 PMCID: PMC4545948 DOI: 10.1186/s40634-015-0025-1

Abstract

Large animal models play a crucial role in sports surgery of the knee, as they are critical for the exploration of new experimental strategies and the clinical translation of novel techniques. The purpose of this contribution is to provide critical aspects of relevant animal models in this field, with a focus on paediatric anterior cruciate ligament (ACL) reconstruction, high tibial osteotomy, and articular cartilage repair. Although there is no single large animal model strictly replicating the human knee joint, the sheep stifle joint shares strong similarities. Studies in large animal models of paediatric ACL reconstruction identified specific risk factors associated with the different surgical techniques. The sheep model of high tibial osteotomy is a powerful new tool to advance the understanding of the effect of axial alignment on the lower extremity on specific issues of the knee joint. Large animal models of both focal chondral and osteochondral defects and of osteoarthritis have brought new findings about the mechanisms of cartilage repair and treatment options. The clinical application of a magnetic device for targeted cell delivery serves as a suitable example of how data from such animal models are directly translated into in clinical cartilage repair. As novel insights from studies in these translational models will advance the basic science, close cooperation in this important field of clinical translation will improve current reconstructive surgical options and open novel avenues for regenerative therapies of musculoskeletal disorders.

Keywords: Articular cartilage repair; Clinical studies; High tibial osteotomy; Large animal models; Magnetic-assisted delivery; Mesenchymal stem cells; Musculoskeletal disorders; Osteoarthritis; Paediatric anterior cruciate ligament reconstruction; Sheep

References

  1. J Bone Joint Surg Am. 1999 May;81(5):711-5 - PubMed
  2. Osteoarthritis Cartilage. 1999 Jan;7(1):15-28 - PubMed
  3. Vet Surg. 1999 Jul-Aug;28(4):242-55 - PubMed
  4. Clin Orthop Relat Res. 1999 Oct;(367 Suppl):S135-46 - PubMed
  5. Clin Orthop Relat Res. 1999 Oct;(367 Suppl):S156-62 - PubMed
  6. J Bone Joint Surg Br. 2000 Mar;82(2):157-9 - PubMed
  7. Biorheology. 2000;37(1-2):163-4 - PubMed
  8. Zentralbl Chir. 2000;125(6):509-15 - PubMed
  9. J Bone Joint Surg Am. 2001 May;83-A(5):725-34 - PubMed
  10. J Bone Joint Surg Br. 2001 May;83(4):513-6 - PubMed
  11. Osteoarthritis Cartilage. 2001 Jul;9(5):447-53 - PubMed
  12. Clin Orthop Relat Res. 2001 Oct;(391 Suppl):S306-17 - PubMed
  13. Clin Orthop Relat Res. 2001 Oct;(391 Suppl):S362-9 - PubMed
  14. Arthroscopy. 2001 Nov-Dec;17(9):946-52 - PubMed
  15. Eur Radiol. 2001;11(11):2319-31 - PubMed
  16. Osteoarthritis Cartilage. 2002 Jun;10(6):432-63 - PubMed
  17. J Pediatr Orthop. 2002 Jul-Aug;22(4):452-7 - PubMed
  18. Arthroscopy. 2002 Sep;18(7):730-4 - PubMed
  19. Clin Orthop Relat Res. 2003 Feb;(407):215-27 - PubMed
  20. Knee Surg Sports Traumatol Arthrosc. 2003 May;11(3):132-8 - PubMed
  21. J Bone Joint Surg Br. 1957 May;39-B(2):248-60 - PubMed
  22. Osteoarthritis Cartilage. 2003 Nov;11(11):810-20 - PubMed
  23. J Bone Miner Res. 1992 Dec;7 Suppl 2:S411-8 - PubMed
  24. J Pediatr. 1952 Apr;40(4):423-41 - PubMed
  25. Acta Anat (Basel). 1992;143(4):335-40 - PubMed
  26. Clin Orthop Relat Res. 2004 May;(422):214-23 - PubMed
  27. J Bone Joint Surg Am. 2005 Sep;87(9):1911-20 - PubMed
  28. Knee. 2005 Dec;12(6):435-40 - PubMed
  29. Osteoarthritis Cartilage. 2006 Jan;14(1):13-29 - PubMed
  30. J Orthop Res. 2006 May;24(5):1001-10 - PubMed
  31. Knee Surg Sports Traumatol Arthrosc. 2006 Dec;14(12):1307-14 - PubMed
  32. Osteoarthritis Cartilage. 2006 Nov;14(11):1119-25 - PubMed
  33. Am J Sports Med. 2006 Nov;34(11):1824-31 - PubMed
  34. Vet Comp Orthop Traumatol. 2006;19(3):142-6 - PubMed
  35. Arthroscopy. 2006 Nov;22(11):1180-6 - PubMed
  36. Rev Chir Orthop Reparatrice Appar Mot. 2006 Sep;92(5 Suppl):2S169-2S194 - PubMed
  37. Arthroscopy. 2007 Aug;23(8):833-8 - PubMed
  38. Arthroscopy. 2007 Aug;23(8):852-61 - PubMed
  39. Arthroscopy. 2008 Jan;24(1):69-76 - PubMed
  40. J Orthop Res. 2008 Sep;26(9):1194-8 - PubMed
  41. Arthroscopy. 2008 Jul;24(7):824-33 - PubMed
  42. Am J Sports Med. 2008 Dec;36(12):2437-43 - PubMed
  43. Arthroscopy. 2008 Nov;24(11):1221-31 - PubMed
  44. Arch Orthop Trauma Surg. 2009 Aug;129(8):1037-46 - PubMed
  45. J Bone Joint Surg Br. 2008 Dec;90(12):1548-57 - PubMed
  46. J Orthop Res. 2009 Nov;27(11):1432-8 - PubMed
  47. Am J Sports Med. 2009 Nov;37 Suppl 1:10S-19S - PubMed
  48. Knee Surg Sports Traumatol Arthrosc. 2010 Oct;18(10):1369-73 - PubMed
  49. Arthroscopy. 2009 Dec;25(12):1435-41 - PubMed
  50. Technol Health Care. 2009;17(5-6):403-10 - PubMed
  51. J Orthop Res. 1991 May;9(3):330-40 - PubMed
  52. Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):419-33 - PubMed
  53. Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):417-8 - PubMed
  54. Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):434-47 - PubMed
  55. Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):448-62 - PubMed
  56. Am J Sports Med. 2010 May;38(5):943-9 - PubMed
  57. J Bone Joint Surg Br. 2010 Apr;92(4):602-8 - PubMed
  58. J Bone Joint Surg Br. 2010 Sep;92(9):1245-52 - PubMed
  59. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S10-6 - PubMed
  60. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S106-12 - PubMed
  61. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S17-23 - PubMed
  62. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S2-6 - PubMed
  63. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S24-34 - PubMed
  64. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S35-52 - PubMed
  65. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S53-65 - PubMed
  66. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S66-79 - PubMed
  67. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S80-92 - PubMed
  68. Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S93-105 - PubMed
  69. Adv Mater. 2009 Sep 4;21(32-33):3419-24 - PubMed
  70. Knee Surg Sports Traumatol Arthrosc. 2011 Apr;19(4):536-42 - PubMed
  71. J Bone Joint Surg Br. 2011 Jan;93(1):120-5 - PubMed
  72. Am J Sports Med. 2011 Jun;39(6):1170-9 - PubMed
  73. J Knee Surg. 2011 Mar;24(1):45-53 - PubMed
  74. Am J Sports Med. 2011 Aug;39(8):1731-40 - PubMed
  75. Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):82-9 - PubMed
  76. Tissue Eng Part C Methods. 2012 May;18(5):329-39 - PubMed
  77. Dtsch Arztebl Int. 2011 Oct;108(40):669-77 - PubMed
  78. Knee Surg Sports Traumatol Arthrosc. 2012 Mar;20(3):423-35 - PubMed
  79. Am J Sports Med. 2012 Apr;40(4):828-36 - PubMed
  80. Osteoarthritis Cartilage. 2012 Apr;20(4):261-7 - PubMed
  81. J Tissue Eng Regen Med. 2014 Jan;8(1):41-9 - PubMed
  82. Osteoarthritis Cartilage. 2012 Sep;20(9):1046-55 - PubMed
  83. Osteoarthritis Cartilage. 2012 Oct;20(10):1161-9 - PubMed
  84. Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):228-36 - PubMed
  85. Knee Surg Sports Traumatol Arthrosc. 2013 Jan;21(1):39-48 - PubMed
  86. J Knee Surg. 2012 May;25(2):85-97 - PubMed
  87. Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1666-77 - PubMed
  88. Osteoarthritis Cartilage. 2013 Apr;21(4):614-24 - PubMed
  89. Tissue Eng Part C Methods. 2013 Nov;19(11):885-91 - PubMed
  90. Eur Cell Mater. 2013 Apr 16;25:229-47 - PubMed
  91. Am J Sports Med. 2013 Jun;41(6):1255-64 - PubMed
  92. Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1511-6 - PubMed
  93. Eur Cell Mater. 2013 May 02;25:248-67 - PubMed
  94. J Pediatr Orthop. 2013 Jul-Aug;33(5):585-6 - PubMed
  95. Eur Cell Mater. 2013 Jun 28;25:299-316; discussion 314-6 - PubMed
  96. J Orthop Res. 2013 Nov;31(11):1772-9 - PubMed
  97. J Orthop Res. 2013 Nov;31(11):1814-9 - PubMed
  98. Knee Surg Sports Traumatol Arthrosc. 2014 May;22(5):959-60 - PubMed
  99. Eur Cell Mater. 2014 May 06;27:12-6 - PubMed
  100. Eur Cell Mater. 2014 May 06;27:17-21; discussion 21 - PubMed
  101. Knee Surg Sports Traumatol Arthrosc. 2015 Sep;23(9):2704-14 - PubMed
  102. Gene Ther. 2014 Sep;21(9):811-9 - PubMed
  103. Arthritis Res Ther. 2014;16(3):210 - PubMed
  104. Am J Sports Med. 2014 Nov;42(11):2741-50 - PubMed
  105. Orthopade. 2014 Oct;43(10):923-9 - PubMed
  106. J Orthop Res. 2015 Jan;33(1):63-70 - PubMed
  107. Curr Stem Cell Res Ther. 2015;10(2):121-31 - PubMed
  108. Orthopade. 2014 Nov;43(11):958-65 - PubMed
  109. Osteoarthritis Cartilage. 2014 Oct;22(10):1386-95 - PubMed
  110. Arthroscopy. 2015 Mar;31(3):396-403 - PubMed
  111. Arthroscopy. 2015 Mar;31(3):501-5 - PubMed
  112. Instr Course Lect. 2015;64:555-65 - PubMed
  113. Arch Orthop Trauma Surg. 2015 Jun;135(6):819-30 - PubMed
  114. J Exp Orthop. 2014 Dec;1(1):12 - PubMed
  115. J Exp Orthop. 2014 Dec;1(1):13 - PubMed
  116. J Bone Joint Surg Am. 1987 Sep;69(7):976-83 - PubMed
  117. Arthritis Rheum. 1971 Jul-Aug;14(4):493-502 - PubMed
  118. Skeletal Radiol. 1981;6(4):237-53 - PubMed
  119. Am J Sports Med. 1995 Jul-Aug;23(4):431-5 - PubMed
  120. J Bone Joint Surg Br. 1994 Nov;76(6):960-3 - PubMed
  121. Orthopade. 1993 Nov;22(6):366-71 - PubMed
  122. Am J Sports Med. 1993 May-Jun;21(3):432-7 - PubMed
  123. J Bone Joint Surg Am. 1993 Apr;75(4):532-53 - PubMed
  124. J Bone Joint Surg Am. 1996 May;78(5):721-33 - PubMed
  125. Arthroscopy. 1997 Aug;13(4):456-60 - PubMed
  126. Am J Vet Res. 1977 Nov;38(11):1807-14 - PubMed
  127. J Bone Joint Surg Am. 1997 Oct;79(10):1452-63 - PubMed
  128. Exp Cell Res. 1998 Jan 10;238(1):265-72 - PubMed
  129. J Pediatr Orthop. 1998 Mar-Apr;18(2):149-54 - PubMed
  130. J Orthop Sci. 1998;3(3):150-5 - PubMed
  131. Vet Surg. 1998 Nov-Dec;27(6):596-605 - PubMed

Publication Types