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McNeilly F, Walker I, Allan GM, et al. Bursal lymphocyte proliferation in the presence of phorbol myristate acetate: Effect of IBDV strains on the proliferation response. Avian Pathol. 1999;28(3):301-3doi: 10.1080/03079459994795.
McNeilly, F., Walker, I., Allan, G. M., & Adair, B. M. (1999). Bursal lymphocyte proliferation in the presence of phorbol myristate acetate: Effect of IBDV strains on the proliferation response. Avian pathology : journal of the W.V.P.A, 28(3), 301-3. https://doi.org/10.1080/03079459994795
McNeilly, F, et al. "Bursal lymphocyte proliferation in the presence of phorbol myristate acetate: Effect of IBDV strains on the proliferation response." Avian pathology : journal of the W.V.P.A vol. 28,3 (1999): 301-3. doi: https://doi.org/10.1080/03079459994795
McNeilly F, Walker I, Allan GM, Adair BM. Bursal lymphocyte proliferation in the presence of phorbol myristate acetate: Effect of IBDV strains on the proliferation response. Avian Pathol. 1999 Jun;28(3):301-3. doi: 10.1080/03079459994795. PMID: 26915386.
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Avian Pathol. 1999 Jun;28(3):301-3. doi: 10.1080/03079459994795.

Bursal lymphocyte proliferation in the presence of phorbol myristate acetate: Effect of IBDV strains on the proliferation response.

Avian pathology : journal of the W.V.P.A

F McNeilly, I Walker, G M Allan, B M Adair

Affiliations

  1. a Veterinary Sciences Division , Stormont , Belfast , BT4 3SD , UK.

PMID: 26915386 DOI: 10.1080/03079459994795

Abstract

Phorbol myristate acetate (PMA) was shown to be highly mitogenic for bursal lymphocytes (optimal concentration 2 μg/ml). Groups of 1-day-old chickens were inoculated with infectious bursal disease virus (IBDV, vaccine or virulent strains). Seven days after infection bursae were removed and the proliferation response of the bursal lymphocytes to PMA was determined. A significant reduction in the proliferation response was observed in the IBDV-inoculated birds. The results confirm that PMA is mitogenic for bursal lymphocytes and also demonstrate the usefulness of this in vitro assay for investigations into immune dysfunction in the bursa of Fabricius.

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