Display options
Cite
Alizadehasl A, Sohrabi B, Panjavi L, et al. Comparison of the Effects of Coronary Artery Bypass Grafting Versus Medical Therapy on Short and Long Term Outcomes in Octogenarian Patients With Multi-Vessel Coronary Artery Disease. Res Cardiovasc Med. 2016;5(1):e30590doi: 10.5812/cardiovascmed.30590.
Alizadehasl, A., Sohrabi, B., Panjavi, L., Sadeghpour, A., Azarfarin, R., Ghadrdoost, B., Zolfaghari, R., & Habibzadeh, A. (2016). Comparison of the Effects of Coronary Artery Bypass Grafting Versus Medical Therapy on Short and Long Term Outcomes in Octogenarian Patients With Multi-Vessel Coronary Artery Disease. Research in cardiovascular medicine, 5(1), e30590. https://doi.org/10.5812/cardiovascmed.30590
Alizadehasl, Azin, et al. "Comparison of the Effects of Coronary Artery Bypass Grafting Versus Medical Therapy on Short and Long Term Outcomes in Octogenarian Patients With Multi-Vessel Coronary Artery Disease." Research in cardiovascular medicine vol. 5,1 (2016): e30590. doi: https://doi.org/10.5812/cardiovascmed.30590
Alizadehasl A, Sohrabi B, Panjavi L, Sadeghpour A, Azarfarin R, Ghadrdoost B, Zolfaghari R, Habibzadeh A. Comparison of the Effects of Coronary Artery Bypass Grafting Versus Medical Therapy on Short and Long Term Outcomes in Octogenarian Patients With Multi-Vessel Coronary Artery Disease. Res Cardiovasc Med. 2016 Jan 09;5(1):e30590. doi: 10.5812/cardiovascmed.30590. eCollection 2016 Feb. PMID: 26889460; PMCID: PMC4752697.
Copy Download .nbib Format: NLM
Share it on

Res Cardiovasc Med. 2016 Jan 09;5(1):e30590. doi: 10.5812/cardiovascmed.30590. eCollection 2016 Feb.

Comparison of the Effects of Coronary Artery Bypass Grafting Versus Medical Therapy on Short and Long Term Outcomes in Octogenarian Patients With Multi-Vessel Coronary Artery Disease.

Research in cardiovascular medicine

Azin Alizadehasl, Bahram Sohrabi, Laleh Panjavi, Anita Sadeghpour, Rasoul Azarfarin, Behshid Ghadrdoost, Reza Zolfaghari, Afshin Habibzadeh

Affiliations

  1. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran.
  2. Madani Cardiovascular Medical and Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.

PMID: 26889460 PMCID: PMC4752697 DOI: 10.5812/cardiovascmed.30590

Abstract

BACKGROUND: Appropriate treatment methods lead to a reduced rate of mortality and morbidity, and an improved quality of life, in patients with multi-vessel coronary artery disease.

OBJECTIVES: In this study, we compared short and long-term outcomes of coronary artery bypass grafting (CABG) versus medical therapy in patients 80 years of age and older with multi-vessel coronary artery disease (MVCAD).

PATIENTS AND METHODS: In this retrospective study, 50 octogenarian patients with MVCAD who underwent CABG were compared with 50 patients in the same condition who were treated with medical therapy during the same time. The primary objective was to compare mortality and morbidity rates, as well as other factors such as the occurrence of chest pain, deterioration of the NYHA functional class, and re-hospitalization, between the two groups. The comparison was made using medical records from the five years post-treatment.

RESULTS: After five years, the overall mortality rate included 11 patients (22%) in the CABG group versus 18 patients (36%) in the medical therapy group; this difference was not significant between the two groups (P = 0.186). Regarding short-term outcomes, in the CABG group, cardiogenic shock occurred in 9 patients (18%), renal failure in 13 patients (26%), pulmonary complications in 9 patients (18%) and neurologic complications in 3 patients (6%); in the medical therapy group, these same complications occurred, respectively, in 6 patients (12%), 7 patients (14%), 10 patients (20%) and 1 patient (2%). In addition to these factors, freedom from chest pain and improvement in the functional class among the CABG group was significantly higher than among the medical therapy group (P = <0.001).

CONCLUSIONS: CABG may be the superior form of treatment for long-term outcomes in terms of the relief of chest pain, improvement of the functional class, reduced need for re-admission, and later death for octogenarians. However, short-term morbidity may be higher among the CABG group, but the mortality rate after 30 days is quite similar.

Keywords: Coronary Artery Bypass Surgery; Coronary Artery Disease; Drug Therapy; Outcome Study

References

  1. Am J Med. 2001 Aug;111(2):89-95 - PubMed
  2. Circulation. 1995 May 1;91(9):2335-44 - PubMed
  3. Asian Cardiovasc Thorac Ann. 2010 Feb;18(1):44-8 - PubMed
  4. Circulation. 2007 Mar 6;115(9):1082-9 - PubMed
  5. Neth Heart J. 2008 Apr;16(4):117-22 - PubMed
  6. Am J Cardiol. 2002 Jul 15;90(2):101-7 - PubMed
  7. Circulation. 2002 May 21;105(20):2378-84 - PubMed
  8. J Am Coll Cardiol. 2000 Mar 1;35(3):731-8 - PubMed
  9. Circulation. 1990 Nov;82(5):1647-58 - PubMed
  10. J Am Coll Cardiol. 1999 Oct;34(4):1262-347 - PubMed
  11. Am J Cardiol. 1988 Jun 1;61(15):1198-203 - PubMed
  12. J Thorac Cardiovasc Surg. 2012 Dec;144(6):1538-9 - PubMed
  13. Ann Thorac Surg. 2002 Oct;74(4):S1408-12 - PubMed
  14. JAMA. 2003 Mar 5;289(9):1117-23 - PubMed
  15. Lancet. 2001 Sep 22;358(9286):951-7 - PubMed
  16. Ann Thorac Surg. 2012 Feb;93(2):523-30 - PubMed
  17. Int J Cardiol. 2008 Nov 12;130(2):291-3 - PubMed
  18. Circulation. 2008 Feb 5;117(5):686-97 - PubMed

Publication Types