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Larrañaga N, Sanchez MJ, Ardanaz E, et al. Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries. J Cancer. 2016;7(3):335-43doi: 10.7150/jca.12943.
Larrañaga, N., Sanchez, M. J., Ardanaz, E., Felipe, S., Marcos-Gragera, R., Ramos, M., Carulla, M., Chirlaque, M. D., Argüelles, M. V., Martos, C., Mateo, A., & Peris-Bonet, R. (2016). Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries. Journal of Cancer, 7(3), 335-43. https://doi.org/10.7150/jca.12943
Larrañaga, Nerea, et al. "Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries." Journal of Cancer vol. 7,3 (2016): 335-43. doi: https://doi.org/10.7150/jca.12943
Larrañaga N, Sanchez MJ, Ardanaz E, Felipe S, Marcos-Gragera R, Ramos M, Carulla M, Chirlaque MD, Argüelles MV, Martos C, Mateo A, Peris-Bonet R. Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries. J Cancer. 2016 Jan 10;7(3):335-43. doi: 10.7150/jca.12943. eCollection 2016. PMID: 26918047; PMCID: PMC4747888.
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J Cancer. 2016 Jan 10;7(3):335-43. doi: 10.7150/jca.12943. eCollection 2016.

Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries.

Journal of Cancer

Nerea Larrañaga, M José Sanchez, Eva Ardanaz, Saray Felipe, Rafael Marcos-Gragera, María Ramos, Marià Carulla, M Dolores Chirlaque, Marcial V Argüelles, Carmen Martos, Antonio Mateo, Rafael Peris-Bonet

Affiliations

  1. 1. Public Health Division of Gipuzkoa, Basque Health Department, Spain. Avda de Navarra 4, 20008-San Sebastian, Spain.; 2. CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
  2. 3. Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.; 2. CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
  3. 4. Navarre Public Health Institute, Pamplona, Spain. C) Leyre 15, Pamplona, 31003, Spain.; 5. Navarra Institute for Health Research (IdiSNA) Pamplona, Spain; 2. CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
  4. 6. Spanish Registry of Childhood Tumours (RTI-SEHOP), Spanish Society of Paediatric Haematology and Oncology, and University of Valencia, Valencia, Spain. Avda. Blasco Ibáñez, 15. 46010-Valencia.
  5. 7. Epidemiology Unit and Girona Cancer Registry (Oncology Coordination Plan). Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute, Girona, Spain.
  6. 8. Registre de càncer de Mallorca. Direcció General de Salut Pública. Illes Balears, Spain.
  7. 9. Tarragona Cancer Registry, Fundació Lliga per a la Investigació i Prevenció del Càncer. IISPV, Reus. Spain.
  8. 10. Department of Epidemiology, Murcia Regional Health Authority, IMIB-Arrixaca Murcia, Spain.; 2. CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
  9. 11. Asturias Cancer Registry. Public Health Directorate, Asturias (Spain).
  10. 2. CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.; 12. Instituto Aragonés de Ciencias de la Salud. Zaragoza, Spain.
  11. 13. Albacete Cancer Registry, Health and Social Welfare Authority, Castilla-La Mancha, Spain.
  12. 6. Spanish Registry of Childhood Tumours (RTI-SEHOP), Spanish Society of Paediatric Haematology and Oncology, and University of Valencia, Valencia, Spain. Avda. Blasco Ibáñez, 15. 46010-Valencia.; 14. RTICC-Spanish Cancer Research Network, ISCiii, RD12/0036/0053, Spain.

PMID: 26918047 PMCID: PMC4747888 DOI: 10.7150/jca.12943

Abstract

OBJECTIVE: To describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain.

METHODS: Cases were drawn from eleven Spanish population-based cancer registries. Incidence was estimated for the period 1983-2007 and trends were evaluated using Joinpoint regression analysis.

RESULTS: The studied tumour groups accounted for 36% of total childhood cancers and 47.6% of those diagnosed in adolescence with annual rates per million of 53.5 and 89.3 respectively. In children 0 to 14 years of age, Neuroblastoma (NB) was the commonest (7.8%) followed by Soft-tissue sarcomas (STS) (6.3%), bone tumours (BT) (6.2%) and renal tumours (RT) (4.5%). NB was the most frequently diagnosed tumour before the 5th birthday, while STS and BT were the commonest at 5-9 years of age, and BT and Carcinoma and other epithelial tumours (COET) at 10-14. COET presented the highest incidence in adolescents, followed by germ-cell tumours (GCT), BT and STS. These four diagnostic groups accounted for 94% of total non-CNS solid tumours, in adolescents. Overall incidence rates increased significantly in children up to 1996 with an annual percentage change (APC) of 2.6% (95%CI: 1.7; 3.6). NB and COET showed significant time trend (APCs: 1.4% and 3.8% respectively) while other tumour groups such as RT, STS, BT or GCT had no significant changes over time. A significant increase was present in NB under the age of 5 and in BT and STS in children aged 10-14 years. In adolescents there were significant increases for all tumours combined (APC=2.7; 95%CI: 1.8-3.6) and for STS, GCT and COET (APCs: 3.2%, 4.4% and 3.5% respectively), while other tumour groups such as hepatic tumours, BT or thyroid carcinomas showed a decreasing trend or no increase.

CONCLUSIONS: Overall, the incidence of the studied cancers in children increased along the period 1983-1996 with no posterior significant rise, while the incidence in adolescents increased significantly over the whole period 1983-2007. Several specific tumour groups showed significant rises or decrements in childhood or adolescence, although the small number of cases precludes showing significant trends or inflexion points.

Keywords: Spain.; adolescents; cancer; childhood; incidence; population-based study; solid tumour

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