Display options
Cite
Strus M, Okoń K, Nowak B, et al. Distinct effects of Lactobacillus plantarum KL30B and Escherichia coli 3A1 on the induction and development of acute and chronic inflammation. Cent Eur J Immunol. 2016;40(4):420-30doi: 10.5114/ceji.2015.56963.
Strus, M., Okoń, K., Nowak, B., Pilarczyk-Zurek, M., Heczko, P., Gawda, A., Ciszek-Lenda, M., Skowron, B., Baranowska, A., & Marcinkiewicz, J. (2015). Distinct effects of Lactobacillus plantarum KL30B and Escherichia coli 3A1 on the induction and development of acute and chronic inflammation. Central-European journal of immunology, 40(4), 420-30. https://doi.org/10.5114/ceji.2015.56963
Strus, Magdalena, et al. "Distinct effects of Lactobacillus plantarum KL30B and Escherichia coli 3A1 on the induction and development of acute and chronic inflammation." Central-European journal of immunology vol. 40,4 (2015): 420-30. doi: https://doi.org/10.5114/ceji.2015.56963
Strus M, Okoń K, Nowak B, Pilarczyk-Zurek M, Heczko P, Gawda A, Ciszek-Lenda M, Skowron B, Baranowska A, Marcinkiewicz J. Distinct effects of Lactobacillus plantarum KL30B and Escherichia coli 3A1 on the induction and development of acute and chronic inflammation. Cent Eur J Immunol. 2015;40(4):420-30. doi: 10.5114/ceji.2015.56963. Epub 2016 Jan 15. PMID: 26862305; PMCID: PMC4737739.
Copy Download .nbib Format: NLM
Share it on

Cent Eur J Immunol. 2015;40(4):420-30. doi: 10.5114/ceji.2015.56963. Epub 2016 Jan 15.

Distinct effects of Lactobacillus plantarum KL30B and Escherichia coli 3A1 on the induction and development of acute and chronic inflammation.

Central-European journal of immunology

Magdalena Strus, Krzysztof Okoń, Bernadeta Nowak, Magdalena Pilarczyk-Zurek, Piotr Heczko, Anna Gawda, Marta Ciszek-Lenda, Beata Skowron, Agnieszka Baranowska, Janusz Marcinkiewicz

Affiliations

  1. Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland; University Center for Veterinary Medicine, Jagiellonian University and University of Agriculture, Krakow, Poland.
  2. Chair of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland.
  3. Chair of Immunology, Jagiellonian University Medical College, Krakow, Poland.
  4. Chair of Microbiology, Jagiellonian University Medical College, Krakow, Poland.
  5. Department of Pathophysiology, Jagiellonian University Medical College, Krakow, Poland.
  6. University Center for Veterinary Medicine, Jagiellonian University and University of Agriculture, Krakow, Poland; Chair of Immunology, Jagiellonian University Medical College, Krakow, Poland.

PMID: 26862305 PMCID: PMC4737739 DOI: 10.5114/ceji.2015.56963

Abstract

OBJECTIVE: Enteric bacteria are involved in the pathogenesis of ulcerative colitis. In experimental colitis, a breakdown of the intestinal epithelial barrier results in inflow of various gut bacteria, induction of acute inflammation and finally, progression to chronic colitis.

MATERIAL AND METHODS: In the present study we compared pro-inflammatory properties of two bacterial strains isolated from human microbiome, Escherichia coli 3A1 and Lactobacillus plantarum KL30B. The study was performed using two experimental models of acute inflammation: peritonitis in mice and trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats.

RESULTS: Both bacterial strains induced massive neutrophil infiltration upon injection into sterile peritoneal cavity. However, peritoneal exudate cells stimulated in vitro with E. coli 3A1, produced far more nitric oxide, than those stimulated with L. plantarum KL30B. Interestingly, distinct effect on the development of TNBS-induced colitis was observed after oral administration of the tested bacteria. Lactobacillus plantarum KL30B evoked strong acute colitis. On the contrary, the administration of E. coli 3A1 resulted in a progression of colitis to chronicity.

CONCLUSIONS: Our results show that distinct effects of bacterial administration on the development of ongoing inflammation is strain specific and depends on the final effect of cross-talk between bacteria and cells of the innate immune system.

Keywords: Escherichia coli; Lactobacillus plantarum; TNBS-induced colitis; inflammation; neutrophils

References

  1. Free Radic Biol Med. 2014 Sep;74:108-17 - PubMed
  2. Inflamm Bowel Dis. 2007 Jun;13(6):675-83 - PubMed
  3. Nitric Oxide. 1997 Apr;1(2):177-89 - PubMed
  4. Appl Environ Microbiol. 2004 Jan;70(1):558-68 - PubMed
  5. Gut. 2001 Jan;48(1):132-5 - PubMed
  6. Inflamm Bowel Dis. 2003 May;9(3):179-89 - PubMed
  7. Int J Exp Pathol. 2007 Jun;88(3):155-64 - PubMed
  8. Immunity. 2014 Jan 16;40(1):66-77 - PubMed
  9. Clin Microbiol Rev. 1998 Jan;11(1):142-201 - PubMed
  10. Infect Immun. 2001 Apr;69(4):2277-85 - PubMed
  11. Gut. 1999 Dec;45(6):864-73 - PubMed
  12. Blood. 1982 Sep;60(3):618-22 - PubMed
  13. Crit Rev Oncol Hematol. 2012 Jun;82(3):296-309 - PubMed
  14. Inflamm Bowel Dis. 2005 Mar;11(3):265-71 - PubMed
  15. Carcinogenesis. 2012 May;33(5):949-55 - PubMed
  16. Can J Gastroenterol. 2012 Jan;26(1):33-9 - PubMed
  17. J Clin Pathol. 1987 Jul;40(7):782-6 - PubMed
  18. World J Gastroenterol. 2005 Sep 7;11(33):5185-92 - PubMed
  19. J Physiol Pharmacol. 2004 Dec;55(4):823-36 - PubMed
  20. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1328-38 - PubMed
  21. Arch Immunol Ther Exp (Warsz). 2012 Feb;60(1):43-54 - PubMed
  22. Lancet. 1999 Aug 21;354(9179):635-9 - PubMed
  23. Int Immunopharmacol. 2014 Jul;21(1):186-92 - PubMed
  24. PLoS One. 2009 Sep 16;4(9):e7056 - PubMed
  25. ISME J. 2007 Sep;1(5):403-18 - PubMed
  26. Free Radic Res. 2012 Dec;46(12):1427-36 - PubMed
  27. BMC Gastroenterol. 2013 Apr 08;13:61 - PubMed
  28. J Dig Dis. 2012 Aug;13(8):421-9 - PubMed
  29. Am J Physiol. 1996 Oct;271(4 Pt 2):R967-72 - PubMed
  30. Clin Diagn Lab Immunol. 2004 Mar;11(2):372-8 - PubMed
  31. Int Immunopharmacol. 2015 Apr;25(2):504-10 - PubMed
  32. Br J Nutr. 2007 Jan;97(1):96-103 - PubMed
  33. J Leukoc Biol. 2005 May;77(5):598-625 - PubMed
  34. PLoS One. 2011;6(8):e23256 - PubMed
  35. Infect Immun. 2003 Dec;71(12):6747-53 - PubMed
  36. Nitric Oxide. 2005 Aug;13(1):42-53 - PubMed
  37. Mucosal Immunol. 2015 Jan;8(1):152-60 - PubMed
  38. Mucosal Immunol. 2014 Jul;7(4):869-78 - PubMed
  39. Am J Gastroenterol. 1997 Dec;92(12 Suppl):5S-11S - PubMed
  40. J Clin Biochem Nutr. 2007 Jul;41(1):18-26 - PubMed
  41. J Immunol. 2001 May 15;166(10):6323-31 - PubMed
  42. Dig Dis Sci. 1994 Dec;39(12):2575-88 - PubMed

Publication Types