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Borowska A, Stelmaszczyk-Emmel A, Pawelec K. Central nervous system haemorrhage causing early death in acute promyelocytic leukaemia. Cent Eur J Immunol. 2016;40(4):486-8doi: 10.5114/ceji.2015.56975.
Borowska, A., Stelmaszczyk-Emmel, A., & Pawelec, K. (2015). Central nervous system haemorrhage causing early death in acute promyelocytic leukaemia. Central-European journal of immunology, 40(4), 486-8. https://doi.org/10.5114/ceji.2015.56975
Borowska, Anna, et al. "Central nervous system haemorrhage causing early death in acute promyelocytic leukaemia." Central-European journal of immunology vol. 40,4 (2015): 486-8. doi: https://doi.org/10.5114/ceji.2015.56975
Borowska A, Stelmaszczyk-Emmel A, Pawelec K. Central nervous system haemorrhage causing early death in acute promyelocytic leukaemia. Cent Eur J Immunol. 2015;40(4):486-8. doi: 10.5114/ceji.2015.56975. Epub 2016 Jan 15. PMID: 26862315; PMCID: PMC4737747.
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Cent Eur J Immunol. 2015;40(4):486-8. doi: 10.5114/ceji.2015.56975. Epub 2016 Jan 15.

Central nervous system haemorrhage causing early death in acute promyelocytic leukaemia.

Central-European journal of immunology

Anna Borowska, Anna Stelmaszczyk-Emmel, Katarzyna Pawelec

Affiliations

  1. Student's Scientific Group 'SPHEROCYTE' Department of Paediatric Haematology and Oncology, Medical University of Warsaw, Poland.
  2. Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Poland.
  3. Department of Paediatric Haematology and Oncology, Medical University of Warsaw, Poland.

PMID: 26862315 PMCID: PMC4737747 DOI: 10.5114/ceji.2015.56975

Abstract

Acute promyelocytic leukaemia (APL) is a rare type of paediatric leukaemia characterised by a specific genetic mutation and life-threatening coagulopathy. The discovery of all-trans retinoic acid (ATRA), which acts directly on promyelocytic locus-retinoic acid receptor α (PML-RARα) gene product, brought a revolution to the therapy of this disorder. Unfortunately, despite an improvement in the complete remission rate, the early death (ED) rate has not changed significantly, and the haemorrhages remain a major problem. The most common bleeding site, which accounts for about 65-80% of haemorrhages, is the central nervous system. Second in line are pulmonary haemorrhages (32%), while gastrointestinal bleedings are relatively rare. Haemorrhages result from thrombocytopaenia, disseminated intravascular coagulopathy (DIC), and systemic fibrinolysis. Herein we present a boy aged one year and nine months with APL. The patient was not eligible for ATRA administration due to poor clinical condition. He developed bleeding diathesis that presented as disseminated intravascular coagulation (DIC) and led to intracranial haemorrhage, which resulted in the patient's death.

Keywords: acute promyelocytic leukaemia; coagulopathy; early death

References

  1. Thromb Res. 2010 Apr;125 Suppl 2:S51-4 - PubMed
  2. Oncogene. 2001 Oct 29;20(49):7154-60 - PubMed
  3. Cancer. 2015 Nov 15;121(22):3990-7 - PubMed
  4. Blood. 2009 Feb 26;113(9):1875-91 - PubMed
  5. Mediterr J Hematol Infect Dis. 2014 Apr 15;6(1):e2014032 - PubMed
  6. Semin Hematol. 2001 Jan;38(1):4-12 - PubMed
  7. Best Pract Res Clin Haematol. 2014 Mar;27(1):69-78 - PubMed
  8. Blood. 1996 Jan 1;87(1):308-13 - PubMed
  9. Best Pract Res Clin Haematol. 2009 Mar;22(1):153-63 - PubMed
  10. Best Pract Res Clin Haematol. 2014 Mar;27(1):3-9 - PubMed
  11. Memo. 2013 Feb;6(1):54-62 - PubMed
  12. Thromb Res. 2014 May;133 Suppl 2:S112-6 - PubMed
  13. Am J Hematol. 2012 Jun;87(6):596-603 - PubMed

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