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Satyanarayana K, Sravanthi K, Shaker IA, et al. Role of chrysin on expression of insulin signaling molecules. J Ayurveda Integr Med. 2015;6(4):248-58doi: 10.4103/0975-9476.157951.
Satyanarayana, K., Sravanthi, K., Shaker, I. A., Ponnulakshmi, R., & Selvaraj, J. (2015). Role of chrysin on expression of insulin signaling molecules. Journal of Ayurveda and integrative medicine, 6(4), 248-58. https://doi.org/10.4103/0975-9476.157951
Satyanarayana, Kottireddy, et al. "Role of chrysin on expression of insulin signaling molecules." Journal of Ayurveda and integrative medicine vol. 6,4 (2015): 248-58. doi: https://doi.org/10.4103/0975-9476.157951
Satyanarayana K, Sravanthi K, Shaker IA, Ponnulakshmi R, Selvaraj J. Role of chrysin on expression of insulin signaling molecules. J Ayurveda Integr Med. 2015 Oct-Dec;6(4):248-58. doi: 10.4103/0975-9476.157951. PMID: 26834424; PMCID: PMC4719485.
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J Ayurveda Integr Med. 2015 Oct-Dec;6(4):248-58. doi: 10.4103/0975-9476.157951.

Role of chrysin on expression of insulin signaling molecules.

Journal of Ayurveda and integrative medicine

Kottireddy Satyanarayana, Koora Sravanthi, Ivvala Anand Shaker, Rajagopal Ponnulakshmi, Jayaraman Selvaraj

Affiliations

  1. Department of Medical Biochemistry, Bharath University, Chennai, Tamil Nadu, India.
  2. Department of Pharmacology, Sakshi Medical College and Research Centre, Guna, Madhya Pradesh, India.
  3. Department of Zoology, PG and Research, Ethiraj College for Women, Chennai, Tamil Nadu, India.
  4. Department of Biotechnology, PG and Research, Holy Cross College, Trichy, Tamil Nadu, India.

PMID: 26834424 PMCID: PMC4719485 DOI: 10.4103/0975-9476.157951

Abstract

BACKGROUND: Currently available drugs are unsuccessful for the treatment of tye-2 diabetes due to their adverseside-effects. Hence, a search for novel drugs, especially ofplant origin, continues. Chrysin (5,7-dihydroxyflavone) is a flavonoid, natural component of traditional medicinal herbs, present in honey, propolis and many plant extracts that hasbeen used in traditional medicine around the world to treat numerous ailments.

OBJECTIVE: The present study was aimed to identify the protective role of chrysin on the expression of insulin-signaling molecules in the skeletal muscle of high fat and sucrose-induced type-2 diabetic adult male rats.

MATERIALS AND METHODS: The oral effective dose of chrysin (100 mg/kg body weight) was given once a day until the end of the study (30 days post-induction of diabetes) to high fat diet-induced diabetic rats. At the end of the experimental period, fasting blood glucose, oral glucose tolerance, serum lipid profile, lipid peroxidation (LPO) and free radical generation, as well as the levels of insulin signaling molecules and tissue glycogen in the gastrocnemius muscle were assessed.

RESULTS: Diabetic rats showed impaired glucose tolerance and impairment in insulin signaling molecules (IR, IRS-1, p-IRS-1Tyr(632), p- Akt(Thr308)), glucose transporter subtype 4 [GLUT4] proteins and glycogen concentration. Serum insulin, lipid profile, LPO and free radical generation were found to be increased in diabetic control rats. The treatment with chrysin normalized the altered levels of blood glucose, serum insulin, lipid profile, LPO and insulin signaling molecules as well as GLUT4 proteins.

CONCLUSION: Our present findings indicate that chrysin improves glycemic control through activation of insulin signal transduction in the gastrocnemius muscle of high fat and sucrose-induced type-2 diabetic male rats.

Keywords: Chrysin; gastrocnemius muscle; high fat diet; insulin signaling; type-2 diabetes

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