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Machado D, Castro J, Palmeira-de-Oliveira A, et al. Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions. Front Microbiol. 2016;6:1528doi: 10.3389/fmicb.2015.01528.
Machado, D., Castro, J., Palmeira-de-Oliveira, A., Martinez-de-Oliveira, J., & Cerca, N. (2015). Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions. Frontiers in microbiology, 61528. https://doi.org/10.3389/fmicb.2015.01528
Machado, Daniela, et al. "Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions." Frontiers in microbiology vol. 6 (2015): 1528. doi: https://doi.org/10.3389/fmicb.2015.01528
Machado D, Castro J, Palmeira-de-Oliveira A, Martinez-de-Oliveira J, Cerca N. Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions. Front Microbiol. 2016 Jan 20;6:1528. doi: 10.3389/fmicb.2015.01528. eCollection 2015. PMID: 26834706; PMCID: PMC4718981.
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Front Microbiol. 2016 Jan 20;6:1528. doi: 10.3389/fmicb.2015.01528. eCollection 2015.

Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions.

Frontiers in microbiology

Daniela Machado, Joana Castro, Ana Palmeira-de-Oliveira, José Martinez-de-Oliveira, Nuno Cerca

Affiliations

  1. Laboratory of Research in Biofilms Rosário Oliveira, Centre of Biological Engineering, University of Minho Braga, Portugal.
  2. Laboratory of Research in Biofilms Rosário Oliveira, Centre of Biological Engineering, University of MinhoBraga, Portugal; Instituto de Ciências Biomédicas Abel Salazar, Universidade do PortoPorto, Portugal.
  3. Health Sciences Research Center, Faculty of Health Sciences, University of Beira InteriorCovilhã, Portugal; Labfit, Health Products Research and Development LdaCovilhã, Portugal.
  4. Health Sciences Research Center, Faculty of Health Sciences, University of Beira InteriorCovilhã, Portugal; Child and Woman's Health Department, Centro Hospitalar Cova da BeiraCovilhã, Portugal.

PMID: 26834706 PMCID: PMC4718981 DOI: 10.3389/fmicb.2015.01528

Abstract

Bacterial vaginosis (BV) is the most common genital tract infection in women during their reproductive years and it has been associated with serious health complications, such as preterm delivery and acquisition or transmission of several sexually transmitted agents. BV is characterized by a reduction of beneficial lactobacilli and a significant increase in number of anaerobic bacteria, including Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Bacteroides spp. and Prevotella spp.. Being polymicrobial in nature, BV etiology remains unclear. However, it is certain that BV involves the presence of a thick vaginal multi-species biofilm, where G. vaginalis is the predominant species. Similar to what happens in many other biofilm-related infections, standard antibiotics, like metronidazole, are unable to fully eradicate the vaginal biofilm, which can explain the high recurrence rates of BV. Furthermore, antibiotic therapy can also cause a negative impact on the healthy vaginal microflora. These issues sparked the interest in developing alternative therapeutic strategies. This review provides a quick synopsis of the currently approved and available antibiotics for BV treatment while presenting an overview of novel strategies that are being explored for the treatment of this disorder, with special focus on natural compounds that are able to overcome biofilm-associated antibiotic resistance.

Keywords: Gardnerella vaginalis; antibiotics; bacterial vaginosis; biofilms; emerging therapies

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