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Mahida S, Sacher F, Derval N, et al. Science Linking Pulmonary Veins and Atrial Fibrillation. Arrhythm Electrophysiol Rev. 2015;4(1):40-3doi: 10.15420/aer.2015.4.1.40.
Mahida, S., Sacher, F., Derval, N., Berte, B., Yamashita, S., Hooks, D., Denis, A., Amraoui, S., Hocini, M., Haissaguerre, M., & Jais, P. (2015). Science Linking Pulmonary Veins and Atrial Fibrillation. Arrhythmia & electrophysiology review, 4(1), 40-3. https://doi.org/10.15420/aer.2015.4.1.40
Mahida, Saagar, et al. "Science Linking Pulmonary Veins and Atrial Fibrillation." Arrhythmia & electrophysiology review vol. 4,1 (2015): 40-3. doi: https://doi.org/10.15420/aer.2015.4.1.40
Mahida S, Sacher F, Derval N, Berte B, Yamashita S, Hooks D, Denis A, Amraoui S, Hocini M, Haissaguerre M, Jais P. Science Linking Pulmonary Veins and Atrial Fibrillation. Arrhythm Electrophysiol Rev. 2015 May;4(1):40-3. doi: 10.15420/aer.2015.4.1.40. Epub 2015 May 30. PMID: 26835098; PMCID: PMC4711542.
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Arrhythm Electrophysiol Rev. 2015 May;4(1):40-3. doi: 10.15420/aer.2015.4.1.40. Epub 2015 May 30.

Science Linking Pulmonary Veins and Atrial Fibrillation.

Arrhythmia & electrophysiology review

Saagar Mahida, Frederic Sacher, Nicolas Derval, Benjamin Berte, Seigo Yamashita, Darren Hooks, Arnaud Denis, Sana Amraoui, Meleze Hocini, Michel Haissaguerre, Pierre Jais

Affiliations

  1. Hôpital Cardiologique du Haut-Lévêque and Université Victor Segalen Bordeaux II, Bordeaux, France.

PMID: 26835098 PMCID: PMC4711542 DOI: 10.15420/aer.2015.4.1.40

Abstract

Over the past few decades, significant progress has been made in understanding the mechanistic basis of atrial fibrillation (AF). One of the most important discoveries in this context has been that pulmonary veins (PV) play a prominent role in the pathogenesis of AF. PV isolation has since become the most widely used technique for treatment of paroxysmal AF. Multiple studies have demonstrated that the electrophysiological and anatomical characteristics of PVs create a proarrhythmogenic substrate. The following review discusses the mechanistic links between PVs and AF.

Keywords: Pulmonary vein isolation; ablation; atrial fibrillation; pulmonary vein electrophysiology; pulmonary vein histology

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