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Qiu Z, Liu H, He L, et al. Proton pump inhibitor-induced exfoliative dermatitis: A case report. Exp Ther Med. 2015;11(2):543-546doi: 10.3892/etm.2015.2926.
Qiu, Z., Liu, H., He, L., Ma, Y., Song, H., Bai, W., & Yu, M. (2016). Proton pump inhibitor-induced exfoliative dermatitis: A case report. Experimental and therapeutic medicine, 11(2), 543-546. https://doi.org/10.3892/etm.2015.2926
Qiu, Zhihong, et al. "Proton pump inhibitor-induced exfoliative dermatitis: A case report." Experimental and therapeutic medicine vol. 11,2 (2016): 543-546. doi: https://doi.org/10.3892/etm.2015.2926
Qiu Z, Liu H, He L, Ma Y, Song H, Bai W, Yu M. Proton pump inhibitor-induced exfoliative dermatitis: A case report. Exp Ther Med. 2016 Feb;11(2):543-546. doi: 10.3892/etm.2015.2926. Epub 2015 Dec 08. PMID: 26893644; PMCID: PMC4733946.
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Exp Ther Med. 2016 Feb;11(2):543-546. doi: 10.3892/etm.2015.2926. Epub 2015 Dec 08.

Proton pump inhibitor-induced exfoliative dermatitis: A case report.

Experimental and therapeutic medicine

Zhihong Qiu, Hongtao Liu, Lien He, Yinling Ma, Haojing Song, Wanjun Bai, Meiling Yu

Affiliations

  1. Department of Pharmacy, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China.
  2. Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.

PMID: 26893644 PMCID: PMC4733946 DOI: 10.3892/etm.2015.2926

Abstract

A 74-year-old female patient was admitted to hospital following a road accident with pains in the chest, abdomen, waist, back, nose, left wrist and lower limbs. After 1 week, the patient presented with gastrointestinal bleeding, and thus was treated with protein pump inhibitors (PPIs), including lansoprazole, esomeprazole and omeprazole enteric-coated tablets, in order to inhibit acid secretion and attenuate bleeding. However, the patient developed skin rashes on the chest and right lower limb and foot 28 days following treatment initiation. The skin rashes spread and ulcerated after 3 days, and were associated with tracheal mucosal injury and hemoptysis. Subsequently, treatment of the patient with PPIs was terminated, after which the tracheal hemoptysis and skin rashes markedly improved. In addition, no new skin rashes appeared following termination of the PPI treatment. In the present case, long-term treatment of an elderly patient with PPIs may have induced exfoliative dermatitis, due to hepatic ischemia, hypoxia and acute renal failure, which may have decreased the metabolism of PPIs, resulting in the accumulation of PPI metabolites.

Keywords: exfoliative dermatitis; proton pump inhibitors

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