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Ma Y. Associations of platelet-activating factor acetylhydrolase gene polymorphisms with risk of ischemic stroke. Biomed Rep. 2015;4(2):246-250doi: 10.3892/br.2015.560.
Ma, Y. (2016). Associations of platelet-activating factor acetylhydrolase gene polymorphisms with risk of ischemic stroke. Biomedical reports, 4(2), 246-250. https://doi.org/10.3892/br.2015.560
Ma, Yongsheng. "Associations of platelet-activating factor acetylhydrolase gene polymorphisms with risk of ischemic stroke." Biomedical reports vol. 4,2 (2016): 246-250. doi: https://doi.org/10.3892/br.2015.560
Ma Y. Associations of platelet-activating factor acetylhydrolase gene polymorphisms with risk of ischemic stroke. Biomed Rep. 2016 Feb;4(2):246-250. doi: 10.3892/br.2015.560. Epub 2015 Dec 21. PMID: 26893847; PMCID: PMC4734079.
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Biomed Rep. 2016 Feb;4(2):246-250. doi: 10.3892/br.2015.560. Epub 2015 Dec 21.

Associations of platelet-activating factor acetylhydrolase gene polymorphisms with risk of ischemic stroke.

Biomedical reports

Yongsheng Ma

Affiliations

  1. Department of Geriatrics, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

PMID: 26893847 PMCID: PMC4734079 DOI: 10.3892/br.2015.560

Abstract

Platelet-activating factor acetylhydrolase (PAF-AH) has an important function in the pathogenesis of ischemic stroke. The aim of the present study was to investigate the correlation between the variation of polymorphisms (R92H and V279F) in PAF-AH and ischemic stroke. A total of 375 patients with ischemic stroke and 370 healthy controls were recruited into the study. Polymorphisms of V279F and R92H in PAF-AH were detected by polymerase chain reaction and DNA direct sequencing method. No significant association was observed between V279F and ischemic stroke. However, the RH+HH genotype, RH genotype and H allele of R92H were significantly associated with an increased risk of ischemic stroke (P=0.02, P=0.03 and P=0.02, respectively), In addition, these correlations remained following adjustment for confounding risk factors of stroke. Furthermore, subgroup analysis showed that a significant association with R92H was identified in the large-artery atherosclerotic stroke subgroup. These findings indicated that variation of R92H in the PAF-AH gene may contribute to ischemic stroke susceptibility in the population studied.

Keywords: ischemic stroke; platelet-activating factor acetylhydrolase; polymorphisms

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