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Furukawa M, Toyooka S, Ichimura K, et al. Genetic alterations in lung adenocarcinoma with a micropapillary component. Mol Clin Oncol. 2015;4(2):195-200doi: 10.3892/mco.2015.690.
Furukawa, M., Toyooka, S., Ichimura, K., Yamamoto, H., Soh, J., Hashida, S., Ouchida, M., Shien, K., Asano, H., Tsukuda, K., & Miyoshi, S. (2016). Genetic alterations in lung adenocarcinoma with a micropapillary component. Molecular and clinical oncology, 4(2), 195-200. https://doi.org/10.3892/mco.2015.690
Furukawa, Masashi, et al. "Genetic alterations in lung adenocarcinoma with a micropapillary component." Molecular and clinical oncology vol. 4,2 (2016): 195-200. doi: https://doi.org/10.3892/mco.2015.690
Furukawa M, Toyooka S, Ichimura K, Yamamoto H, Soh J, Hashida S, Ouchida M, Shien K, Asano H, Tsukuda K, Miyoshi S. Genetic alterations in lung adenocarcinoma with a micropapillary component. Mol Clin Oncol. 2016 Feb;4(2):195-200. doi: 10.3892/mco.2015.690. Epub 2015 Dec 02. PMID: 26893860; PMCID: PMC4734214.
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Mol Clin Oncol. 2016 Feb;4(2):195-200. doi: 10.3892/mco.2015.690. Epub 2015 Dec 02.

Genetic alterations in lung adenocarcinoma with a micropapillary component.

Molecular and clinical oncology

Masashi Furukawa, Shinichi Toyooka, Kouichi Ichimura, Hiromasa Yamamoto, Junichi Soh, Shinsuke Hashida, Mamoru Ouchida, Kazuhiko Shien, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi

Affiliations

  1. Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.
  2. Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan; Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.
  3. Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.
  4. Department of Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.

PMID: 26893860 PMCID: PMC4734214 DOI: 10.3892/mco.2015.690

Abstract

Pulmonary adenocarcinoma (PA) with a micropapillary component (PA-MPC) is known as an aggressive subtype of PA. The molecular profiles of PA-MPC have not been well characterized. the pathological reports of patients who underwent surgical resection for lung cancer between April, 2004 and May, 2012 were reviewed. Of the 674 patients diagnosed with PA, 28 were found to have MPC. A total of 138 resected PAs without MPC were selected in the same period to serve as age-, gender- and smoking status-matched controls to the PA-MPC group. Mutational status was determined by the following two methods: SNaPshot assay based on multiplex polymerase chain reaction (PCR), primer extension and capillary electrophoresis that was designed to assess 38 somatic mutations in 8 genes [

Keywords: Kirsten rat sarcoma viral oncogene homolog; echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion gene; endothelial growth factor receptor gene; lung cancer; micropapillary adenocarcinoma

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