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Kim SJ, Kim JH, Gil HW, et al. Hyperuricemia as a marker for progression of immunoglobulin A nephropathy. Kidney Res Clin Pract. 2012;31(3):186-91doi: 10.1016/j.krcp.2012.07.003.
Kim, S. J., Kim, J. H., Gil, H. W., Yang, J. O., Lee, E. Y., & Hong, S. Y. (2012). Hyperuricemia as a marker for progression of immunoglobulin A nephropathy. Kidney research and clinical practice, 31(3), 186-91. https://doi.org/10.1016/j.krcp.2012.07.003
Kim, Su-Ji, et al. "Hyperuricemia as a marker for progression of immunoglobulin A nephropathy." Kidney research and clinical practice vol. 31,3 (2012): 186-91. doi: https://doi.org/10.1016/j.krcp.2012.07.003
Kim SJ, Kim JH, Gil HW, Yang JO, Lee EY, Hong SY. Hyperuricemia as a marker for progression of immunoglobulin A nephropathy. Kidney Res Clin Pract. 2012 Sep;31(3):186-91. doi: 10.1016/j.krcp.2012.07.003. Epub 2012 Jul 20. PMID: 26894025; PMCID: PMC4716087.
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Kidney Res Clin Pract. 2012 Sep;31(3):186-91. doi: 10.1016/j.krcp.2012.07.003. Epub 2012 Jul 20.

Hyperuricemia as a marker for progression of immunoglobulin A nephropathy.

Kidney research and clinical practice

Su-Ji Kim, Jung-Hoon Kim, Hyo-Wook Gil, Jong-Oh Yang, Eun-Young Lee, Sae-Yong Hong

Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

PMID: 26894025 PMCID: PMC4716087 DOI: 10.1016/j.krcp.2012.07.003

Abstract

BACKGROUND: The variable clinical and histopathological manifestations of immunoglobulin A nephropathy (IgAN) make it difficult to predict disease progression. A recent study showed that hyperuricemia, a condition common in hypertension and vascular disease, may contribute to renal dysfunction and histological changes including renal arteriosclerosis, tubular atrophy, and interstitial fibrosis. Herein, we investigated the clinical significance of uric acid level at the time of biopsy, as a marker of IgAN progression.

METHODS: We included 193 patients with biopsy-proven IgAN. Renal disease progression was defined as serum creatinine elevation above 1.2 mg/dL or over 20% elevation from baseline. Hyperuricemia was defined as a serum uric acid level ≥7.3 mg/dL in men and ≥5.3 mg/dL in women, which were 1 standard deviation above the mean value in the normal subjects.

RESULTS: The hyperuricemia group (n=50) had higher blood pressure, body mass index, and serum creatinine, and a greater amount of proteinuria and a lower glomerular filtration rate than the nonhyperuricemia group (n=143). Hyperuricemia increased the risk of IgAN progression (odds ratio, 4.53; 95% confidence interval, 1.31-15.66). The disease progression group (n=26) had a greater frequency of hyperuricemia, hypertension, and nephrotic range proteinuria than the nonprogression group (n=119). The renal survival analysis showed that the hyperuricemia group had a higher rate of IgAN disease progression.

CONCLUSION: Hyperuricemia at the time of diagnosis is an important marker for IgAN progression.

Keywords: Hyperuricemia; Immunoglobulin A nephropathy

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