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Badam RK, Suram J, Babu DB, et al. Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients. J Clin Diagn Res. 2016;10(1):ZC60-2doi: 10.7860/JCDR/2016/16091.7121.
Badam, R. K., Suram, J., Babu, D. B., Waghray, S., Marshal, R., Bontha, S. C., Lavanya, R., & Kanth, S. (2016). Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients. Journal of clinical and diagnostic research : JCDR, 10(1), ZC60-2. https://doi.org/10.7860/JCDR/2016/16091.7121
Badam, Raj Kumar, et al. "Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients." Journal of clinical and diagnostic research : JCDR vol. 10,1 (2016): ZC60-2. doi: https://doi.org/10.7860/JCDR/2016/16091.7121
Badam RK, Suram J, Babu DB, Waghray S, Marshal R, Bontha SC, Lavanya R, Kanth S. Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients. J Clin Diagn Res. 2016 Jan;10(1):ZC60-2. doi: 10.7860/JCDR/2016/16091.7121. Epub 2016 Jan 01. PMID: 26894178; PMCID: PMC4740706.
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J Clin Diagn Res. 2016 Jan;10(1):ZC60-2. doi: 10.7860/JCDR/2016/16091.7121. Epub 2016 Jan 01.

Assessment of Salivary Gland Function Using Salivary Scintigraphy in Pre and Post Radioactive Iodine Therapy in Diagnosed Thyroid Carcinoma Patients.

Journal of clinical and diagnostic research : JCDR

Raj Kumar Badam, Jyotsna Suram, Dara Balaji Gandhi Babu, Shefali Waghray, Rahul Marshal, Sharath Chandra Bontha, Reddy Lavanya, Sudheer Kanth

Affiliations

  1. Reader, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India .
  2. Senior Lecturer, Department of Oral Medicine & Radiology, Shadan Dental College , Hyderabad, India .
  3. Professor and Head of Department, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India .
  4. Senior Lecturer, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India .
  5. Professor, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India .
  6. Reader, Department of Oral & Maxillofacial Pathology, Mamatha Dental College , Khammam, Telangana State, India .

PMID: 26894178 PMCID: PMC4740706 DOI: 10.7860/JCDR/2016/16091.7121

Abstract

INTRODUCTION: Thyroid carcinoma represents less than 1% of all cancers. The first line of treatment for thyroid cancer is partial/total thyroidectomy. High-dose Iodine(131) therapy using Iodine radioisotopes is commonly used in patients with well differentiated thyroid carcinoma after total thyroidectomy. In this process, the non-thyroidal tissues, such as, salivary gland, stomach and breast tissues also take up radioactive iodine. Salivary gland scintigraphy is widely accepted as a sensitive and valid method for evaluation of salivary gland dysfunction after Radioactive Iodine(131) Therapy (RIT).

AIM: To assess and compare the salivary flow rates, relative uptake and ejection fractions in parotid and submandibular glands just before and one month after Iodine(131) therapy.

MATERIALS AND METHODS: The study was conducted on 24 patients diagnosed with well differentiated thyroid carcinoma who underwent partial/total thyroidectomy and were due for radioactive iodine therapy. These patients were divided into two groups based on the lesion based dosimetry (Group A: 60-100Gy; Group B: 100-150Gy). Salivary gland assessment was done by salivary gland scintigraphy before and after RIT.

STATISTICAL ANALYSIS: The data collected was tabulated and statistically analysed using SPSS software version16 using paired t-test and individual sample t-test.

RESULTS: A statistically significant difference in the uptake percent and ejection fraction percent in the parotid and submandibular glands before RIT and one month after RIT was observed in the study.

CONCLUSION: We inferred from the study that there was an overall decrease in uptake percent and ejection fraction percent one month post RIT in both parotid and submandibular glands. Also, a statistically significant difference was noted in the uptake and ejection fraction percent between Group A and Group B concluding the fact that the damage is dose related.

Keywords: Radioisotopes; Radionuclide imaging; Xerostomia

References

  1. J Oral Pathol Med. 1992 Feb;21(2):70-4 - PubMed
  2. Thyroid. 2013 May;23 (5):609-16 - PubMed
  3. J Oral Maxillofac Surg. 1999 Jun;57(6):738-41 - PubMed
  4. J Nucl Med. 2002 Jan;43(1):61-5 - PubMed
  5. Otolaryngol Clin North Am. 1988 Nov;21(4):649-61 - PubMed
  6. Laryngol Rhinol Otol (Stuttg). 1988 Jul;67(7):362-6 - PubMed
  7. J Nucl Med. 2000 Jul;41(7):1198-202 - PubMed
  8. Nucl Med Mol Imaging. 2011 Sep;45(3):161-8 - PubMed
  9. Laryngoscope. 1967 May;77(5):861-75 - PubMed
  10. J Nucl Med. 2001 Jan;42(1):38-43 - PubMed
  11. Endocr Relat Cancer. 2010 Jun 03;17(3):R161-72 - PubMed
  12. J Nucl Med Technol. 2002 Dec;30(4):165-71; quiz 172-3 - PubMed
  13. Clin Nucl Med. 2002 Nov;27(11):767-71 - PubMed

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