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Lee JH, Son SW, Cho SH. A Comprehensive Review of the Treatment of Atopic Eczema. Allergy Asthma Immunol Res. 2016;8(3):181-90doi: 10.4168/aair.2016.8.3.181.
Lee, J. H., Son, S. W., & Cho, S. H. (2016). A Comprehensive Review of the Treatment of Atopic Eczema. Allergy, asthma & immunology research, 8(3), 181-90. https://doi.org/10.4168/aair.2016.8.3.181
Lee, Ji Hyun, et al. "A Comprehensive Review of the Treatment of Atopic Eczema." Allergy, asthma & immunology research vol. 8,3 (2016): 181-90. doi: https://doi.org/10.4168/aair.2016.8.3.181
Lee JH, Son SW, Cho SH. A Comprehensive Review of the Treatment of Atopic Eczema. Allergy Asthma Immunol Res. 2016 May;8(3):181-90. doi: 10.4168/aair.2016.8.3.181. PMID: 26922927; PMCID: PMC4773205.
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Allergy Asthma Immunol Res. 2016 May;8(3):181-90. doi: 10.4168/aair.2016.8.3.181.

A Comprehensive Review of the Treatment of Atopic Eczema.

Allergy, asthma & immunology research

Ji Hyun Lee, Sag Wook Son, Sang Hyun Cho

Affiliations

  1. Department of Dermatology, The Catholic University of Korea, Seoul, Korea.
  2. Department of Dermatology, Korea University College of Medicine, Seoul, Korea. [email protected].
  3. Department of Dermatology, The Catholic University of Korea, Seoul, Korea. [email protected].

PMID: 26922927 PMCID: PMC4773205 DOI: 10.4168/aair.2016.8.3.181

Abstract

Atopic eczema (AE) is a chronic, inflammatory skin disorder which usually develops in early childhood. In spite of intensive investigations, the causes of AE remain unclear, but are likely to be multifactorial in nature. Environmental factors or genetic-environmental interactions seem to play a key role in disease progression. Among various measures of AE managment, cutaneous hydration, which improves barrier function and relieve itchiness, may be helpful to reduce the need for topical steroid use and therefore should be used as a basic treatment. Avoiding aggravating factors is also a basic treatment of AE. Standard medical treatment with a pharmacologic approach may be necessary if basic treatment fails to control symptoms satisfactorily. Recently, more attention is given to a proactive therapeutic by regular intermittent application of low potency steroids or topical calcineurin inhibitors to prevent new flares. Furthermore, various targeted biologics are being introduced for AE control and are proposed as promising therapies. This paper provides a summary of the recent literature on the manangement of AE and a treatment guideline.

Keywords: Eczema; atopic dermatitis; atopic eczema; epidemiology; prevention; treatment

References

  1. Pediatrics. 2008 Oct;122(4):812-24 - PubMed
  2. J Am Acad Dermatol. 2014 Jul;71(1):116-32 - PubMed
  3. J Am Acad Dermatol. 2002 Mar;46(3):387-93 - PubMed
  4. N Engl J Med. 2014 May 29;370(22):2102-10 - PubMed
  5. N Engl J Med. 2014 Sep 25;371(13):1189-97 - PubMed
  6. Pediatr Dermatol. 2007 Mar-Apr;24(2):118-20 - PubMed
  7. Am J Clin Dermatol. 2003;4(9):641-54 - PubMed
  8. J Allergy Clin Immunol. 2013 Jul;132(1):110-7 - PubMed
  9. J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):361-9; quiz 370 - PubMed
  10. J Am Acad Dermatol. 2005 Feb;52(2):240-6 - PubMed
  11. J Am Acad Dermatol. 2014 Dec;71(6):1218-33 - PubMed
  12. Exp Dermatol. 2008 Nov;17(11):953-7 - PubMed
  13. Int Arch Allergy Immunol. 2005 Aug;137(4):319-25 - PubMed
  14. Allergy Asthma Immunol Res. 2014 Nov;6(6):517-24 - PubMed
  15. J Allergy Clin Immunol. 2011 Nov;128(5):1128-30 - PubMed
  16. J Dermatol. 2009 Sep;36(9):512-4 - PubMed
  17. Curr Opin Allergy Clin Immunol. 2012 Aug;12(4):427-33 - PubMed
  18. J Ethnopharmacol. 2011 Jan 27;133(2):810-7 - PubMed
  19. Lancet. 2007 Oct 20;370(9596):1422-31 - PubMed
  20. Br J Dermatol. 2002 Aug;147(2):324-30 - PubMed
  21. Br J Dermatol. 2008 Apr;158(4):786-92 - PubMed
  22. Clin Exp Allergy. 2007 Apr;37(4):526-35 - PubMed
  23. J Allergy Clin Immunol. 2008 Jan;121(1):122-8 - PubMed
  24. Immunol Allergy Clin North Am. 2010 Aug;30(3):309-21 - PubMed
  25. Allergy. 2005 May;60(5):693-6 - PubMed
  26. J Allergy Clin Immunol. 2011 Dec;128(6):1139-1150.e4 - PubMed
  27. Br J Dermatol. 1998 Nov;139(5):834-9 - PubMed
  28. Semin Cutan Med Surg. 2008 Jun;27(2):115-27 - PubMed
  29. Clin Exp Dermatol. 1992 Nov;17(6):385-91 - PubMed
  30. J Am Acad Dermatol. 2000 Apr;42(4):653-9 - PubMed
  31. J Allergy Clin Immunol. 1999 Jan;103(1 Pt 1):125-38 - PubMed
  32. Acta Derm Venereol. 2012 Sep;92(5):455-61 - PubMed
  33. J Invest Dermatol. 2007 Apr;127(4):808-16 - PubMed
  34. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD005205 - PubMed
  35. Ann Allergy Asthma Immunol. 1998 Mar;80(3):263-8 - PubMed
  36. J Allergy Clin Immunol. 1999 Dec;104(6):1280-4 - PubMed
  37. Immunol Allergy Clin North Am. 2010 Aug;30(3):337-50 - PubMed
  38. BMJ. 2003 Jun 21;326(7403):1367 - PubMed
  39. Pediatrics. 2009 May;123(5):e808-14 - PubMed
  40. Am J Clin Dermatol. 2012 Apr 1;13(2):113-23 - PubMed
  41. J Am Acad Dermatol. 2005 Aug;53(2):338-40 - PubMed
  42. J Am Acad Dermatol. 2014 Aug;71(2):327-49 - PubMed
  43. J Invest Dermatol. 2009 Mar;129(3):682-9 - PubMed
  44. Clin Exp Allergy. 1998 Nov;28 Suppl 5:52-66; discussion 90-1 - PubMed
  45. Allergy. 2006 Feb;61(2):202-5 - PubMed
  46. Br J Dermatol. 2005 Jan;152(1):110-4 - PubMed
  47. Curr Opin Pediatr. 2009 Aug;21(4):486-90 - PubMed
  48. Pediatr Allergy Immunol. 2012 May;23(3):285-8 - PubMed
  49. Arch Dermatol. 1999 Dec;135(12):1522-5 - PubMed
  50. J Allergy Clin Immunol. 2007 Jul;120(1):164-70 - PubMed
  51. J Allergy Clin Immunol. 2007 Nov;120(5):1223-5 - PubMed
  52. Allergy. 2006 May;61(5):556-62 - PubMed
  53. N Engl J Med. 2014 Jul 10;371(2):130-9 - PubMed
  54. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD004416 - PubMed
  55. J Allergy Clin Immunol. 2008 Apr;121(4):947-54.e15 - PubMed
  56. J Am Acad Dermatol. 2014 Oct;71(4):814-21 - PubMed
  57. Lancet. 2006 Aug 26;368(9537):733-43 - PubMed
  58. Curr Opin Pediatr. 2003 Aug;15(4):399-404 - PubMed
  59. J Immunol. 1997 Aug 15;159(4):1739-45 - PubMed
  60. J Allergy Clin Immunol. 2013 Feb;131(2):295-9.e1-27 - PubMed
  61. J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58 - PubMed
  62. Nat Genet. 2006 Apr;38(4):441-6 - PubMed
  63. J Am Acad Dermatol. 2009 Jan;60(1):77-84 - PubMed
  64. J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):522-6 - PubMed
  65. Dermatology. 2005;211(2):174-87 - PubMed
  66. J Am Acad Dermatol. 1993 Feb;28(2 Pt 1):189-97 - PubMed
  67. Dermatitis. 2007 Jun;18(2):82-91 - PubMed
  68. Pediatrics. 2008 Dec;122(6):e1210-8 - PubMed
  69. Br J Dermatol. 2001 Mar;144(3):507-13 - PubMed
  70. Allergy. 2001;56 Suppl 67:75-7 - PubMed
  71. Allergy. 2001 Jun;56(6):512-7 - PubMed
  72. J Allergy Clin Immunol. 2009 Dec;124(6):1251-8.e23 - PubMed
  73. J Korean Med Sci. 2001 Apr;16(2):155-64 - PubMed
  74. Hosp Med. 2002 Nov;63(11):653-6 - PubMed
  75. J Allergy Clin Immunol. 2002 Sep;110(3):500-6 - PubMed
  76. Arch Dermatol. 1998 Jul;134(7):799-804 - PubMed
  77. Allergy Asthma Immunol Res. 2012 Nov;4(6):313-25 - PubMed
  78. Br J Dermatol. 2011 May;164(5):1078-82 - PubMed
  79. J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1360-8 - PubMed
  80. J Am Acad Dermatol. 2005 Aug;53(2 Suppl 2):S186-94 - PubMed
  81. J Invest Dermatol. 2011 Jan;131(1):67-73 - PubMed
  82. J Eur Acad Dermatol Venereol. 2010 Jan;24(1):43-9 - PubMed
  83. Clin Exp Dermatol. 2000 Oct;25(7):552-8 - PubMed
  84. Ann Dermatol. 2014 Aug;26(4):528-31 - PubMed
  85. Int Arch Allergy Immunol. 2013;162(1):79-85 - PubMed
  86. J Allergy Clin Immunol. 2001 Apr;107(4):703-6 - PubMed
  87. J Allergy Clin Immunol. 2009 Jan;123(1):3-11; quiz 12-3 - PubMed
  88. J Eur Acad Dermatol Venereol. 2012 Aug;26(8):1045-60 - PubMed
  89. J Allergy Clin Immunol Pract. 2013 Mar;1(2):142-51 - PubMed
  90. J Allergy Clin Immunol. 2003 Oct;112(4):667-74 - PubMed
  91. Allergy Asthma Immunol Res. 2015 Mar;7(2):101-5 - PubMed
  92. Skin Pharmacol Physiol. 2006;19(3):153-8 - PubMed
  93. Arch Dermatol. 2005 Dec;141(12):1556-9 - PubMed
  94. J Am Acad Dermatol. 2006 Jan;54(1):68-72 - PubMed

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