Ann Thorac Med. 2016 Jan-Mar;11(1):66-70. doi: 10.4103/1817-1737.172298.
Increased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgery.
Annals of thoracic medicine
Mufide Oncel, Aysel Kiyici, Murat Oncel, Guven Sadi Sunam, Emel Sahin, Bahattin Adam
Affiliations
Affiliations
- Department of Biochemistry, Medical Faculty, Mevlana University, Konya, Turkey.
- Department of Thoracic Surgery, Medical Faculty, Selcuk University, Selcuklu, Konya, Turkey.
PMID: 26933460
PMCID: PMC4748618 DOI: 10.4103/1817-1737.172298
Abstract
BACKGROUND: Videothoracoscopic surgery leads to general organ hypoperfusion by reducing mean arterial pressure, systemic vascular resistance, and end-diastolic volume index. Oxidative stress occurs as a result of hypoperfusion. Evaluation of the short-term effects of videothoracoscopic sympathectomy on serum ischemia-modified albumin (IMA), malondialdehyde (MDA), and nitric oxide (NO) levels in patients with primary hyperhidrosis was aimed.
METHODS: Twenty-six patients who underwent videothoracoscopic surgery were contributed in this study. Venous blood samples were obtained from these patients 1 h before and after the surgery. IMA, MDA, and NO levels were measured in serum samples by colorimetric methods. Albumin concentrations were also measured for each sample, and albumin-adjusted IMA levels were calculated.
RESULTS: Postoperative IMA, albumin-adjusted IMA, and MDA values were significantly higher compared to the preoperative values (P = 0.003, 0.027, 0.018, respectively). However, postoperative NO levels were lower than the preoperative values (P = 0.002). There was no significant difference between pre- and postoperative albumin concentrations, and there was no significant correlation between the parameters tested.
CONCLUSIONS: We can conclude that elevation in MDA and IMA levels after videothoracoscopic surgery was caused by increased oxidative stress due to minimal ischemia-reperfusion injury after the infusion of CO2 during the surgical process. Videothoracoscopic sympathectomy operation causes a decrease in NO production, and this should be taken in consideration when evaluating nitrosative stress in videothoracoscopic surgery.
Keywords: Ischemia modified albumin; malondialdehyde; nitric oxide; videothoracoscopic surgery
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