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Belmonte M, Hoofd C, Weng AP, et al. Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?. Curr Oncol. 2016;23(1):34-41doi: 10.3747/co.23.2806.
Belmonte, M., Hoofd, C., Weng, A. P., & Giambra, V. (2016). Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?. Current oncology (Toronto, Ont.), 23(1), 34-41. https://doi.org/10.3747/co.23.2806
Belmonte, M, et al. "Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?." Current oncology (Toronto, Ont.) vol. 23,1 (2016): 34-41. doi: https://doi.org/10.3747/co.23.2806
Belmonte M, Hoofd C, Weng AP, Giambra V. Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?. Curr Oncol. 2016 Feb;23(1):34-41. doi: 10.3747/co.23.2806. Epub 2016 Feb 18. PMID: 26966402; PMCID: PMC4754058.
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Curr Oncol. 2016 Feb;23(1):34-41. doi: 10.3747/co.23.2806. Epub 2016 Feb 18.

Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?.

Current oncology (Toronto, Ont.)

M Belmonte, C Hoofd, A P Weng, V Giambra

Affiliations

  1. Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC.

PMID: 26966402 PMCID: PMC4754058 DOI: 10.3747/co.23.2806

Abstract

T-Cell acute lymphoblastic leukemia (t-all) is a malignancy of white blood cells, characterized by an uncontrolled accumulation of T-cell progenitors. During leukemic progression, immature T cells grow abnormally and crowd into the bone marrow, preventing it from making normal blood cells and spilling out into the bloodstream. Recent studies suggest that only discrete cell populations that possess the ability to recreate the entire tumour might be responsible for the initiation and propagation of t-all. Those unique cells are commonly called "cancer stem cells" or, in the case of hematopoietic malignancies, "leukemia stem cells" (lscs). Like normal hematopoietic stem cells, lscs are thought to be capable of self-renewal, during which, by asymmetrical division, they give rise to an identical copy of themselves as well as to a daughter cell that is no longer capable of self-renewal activity and represents a more "differentiated" progeny. Here, we review the main pathways of self-renewal activity in lscs, focusing on their involvement in the maintenance and development of t-all. New stem cell-directed therapies and lsc-targeted agents are also discussed.

Keywords: Leukemia stem cells; Notch; Wnt; hif; leukemia; mouse models; patient-derived xenografts; t-all; β-catenin

References

  1. Biochim Biophys Acta. 2010 Dec;1806(2):258-67 - PubMed
  2. Blood. 2010 Dec 9;116(24):5268-79 - PubMed
  3. Cancer Res. 2009 Oct 1;69(19):7672-80 - PubMed
  4. Nature. 1999 May 20;399(6733):271-5 - PubMed
  5. Nat Chem Biol. 2010 Nov;6(11):829-36 - PubMed
  6. Blood. 2011 Aug 11;118(6):1579-90 - PubMed
  7. Clin Cancer Res. 2015 Mar 1;21(5):955-61 - PubMed
  8. Cancer Res. 2005 Oct 1;65(19):9047-55 - PubMed
  9. Nat Med. 2009 Jan;15(1):50-8 - PubMed
  10. Science. 1998 Sep 4;281(5382):1509-12 - PubMed
  11. Cancer Cell. 2003 Apr;3(4):363-75 - PubMed
  12. Pediatr Blood Cancer. 2012 May;58(5):815-8 - PubMed
  13. Leukemia. 2009 May;23 (5):925-33 - PubMed
  14. Mol Cancer Ther. 2003 Mar;2(3):235-43 - PubMed
  15. J Exp Med. 1996 May 1;183(5):2283-91 - PubMed
  16. Cancer Cell. 2002 Feb;1(1):75-87 - PubMed
  17. EMBO Rep. 2008 Apr;9(4):377-83 - PubMed
  18. J Natl Cancer Inst. 2003 Apr 2;95(7):516-25 - PubMed
  19. PLoS One. 2011;6(6):e21018 - PubMed
  20. Cell. 2013 Jun 20;153(7):1552-66 - PubMed
  21. Annu Rev Pathol. 2008;3:587-613 - PubMed
  22. Science. 2004 Oct 8;306(5694):269-71 - PubMed
  23. Br J Cancer. 2010 Mar 2;102(5):789-95 - PubMed
  24. Blood Cancer J. 2014 Mar 14;4:e192 - PubMed
  25. Immunity. 2012 Nov 16;37(5):813-26 - PubMed
  26. Science. 2010 Feb 12;327(5967):879-83 - PubMed
  27. Mol Cell Biol. 2003 Jan;23(2):655-64 - PubMed
  28. Nat Med. 2000 Nov;6(11):1278-81 - PubMed
  29. PLoS Biol. 2012;10(11):e1001430 - PubMed
  30. Proc Natl Acad Sci U S A. 1989 Mar;86(6):2031-5 - PubMed
  31. Eur J Cancer. 2006 Jun;42(9):1293-7 - PubMed
  32. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4367-71 - PubMed
  33. Cancer Cell. 2007 Dec;12(6):528-41 - PubMed
  34. Nature. 2003 May 22;423(6938):409-14 - PubMed
  35. Nature. 1999 Apr 1;398(6726):422-6 - PubMed
  36. Blood. 2009 Jul 16;114(3):647-50 - PubMed
  37. Annu Rev Cell Dev Biol. 2009;25:377-406 - PubMed
  38. Klin Padiatr. 2005 Nov-Dec;217(6):310-20 - PubMed
  39. Br J Pharmacol. 2009 Nov;158(5):1183-95 - PubMed
  40. Cancer Gene Ther. 2014 Feb;21(2):83-9 - PubMed
  41. Genes Dev. 2010 Jun 1;24(11):1093-105 - PubMed
  42. J Hematol Oncol. 2013 Jan 05;6:3 - PubMed
  43. J Exp Med. 2007 Aug 6;204(8):1813-24 - PubMed
  44. Curr Opin Cell Biol. 2012 Apr;24(2):232-5 - PubMed
  45. J Exp Med. 2011 Aug 29;208(9):1809-22 - PubMed
  46. Nat Rev Cancer. 2003 Oct;3(10):721-32 - PubMed
  47. Blood. 2015 Jun 18;125(25):3917-27 - PubMed
  48. Nature. 2010 Apr 15;464(7291):1052-7 - PubMed
  49. Oncogene. 2011 Jan 27;30(4):423-33 - PubMed
  50. Science. 1986 May 16;232(4752):884-6 - PubMed
  51. Mol Cell Biol. 2006 Jun;26(12):4642-51 - PubMed
  52. Nature. 2008 May 22;453(7194):529-33 - PubMed
  53. Cell Stem Cell. 2011 Apr 8;8(4):399-411 - PubMed
  54. Cancer Cell. 2004 Jul;6(1):33-43 - PubMed
  55. Science. 2010 Mar 26;327(5973):1650-3 - PubMed
  56. Nature. 2001 Nov 1;414(6859):105-11 - PubMed
  57. Nat Med. 1997 Jul;3(7):730-7 - PubMed
  58. Blood. 2007 Jun 15;109(12):5463-72 - PubMed
  59. Nature. 2005 Apr 14;434(7035):843-50 - PubMed
  60. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11416-20 - PubMed
  61. Nat Immunol. 2005 Mar;6(3):314-22 - PubMed
  62. Cancer Cell. 2011 Apr 12;19(4):484-97 - PubMed
  63. Blood. 2005 Jul 1;106(1):274-86 - PubMed
  64. Nat Med. 2012 Nov;18(11):1693-8 - PubMed
  65. J Biol Chem. 2002 Aug 16;277(33):29936-44 - PubMed
  66. Blood. 2012 Mar 15;119(11):2595-607 - PubMed
  67. Nature. 2009 Oct 1;461(7264):614-20 - PubMed
  68. Blood. 2011 Jun 9;117(23):6267-76 - PubMed
  69. Cell. 2012 Jun 8;149(6):1192-205 - PubMed
  70. Development. 2008 Feb;135(3):411-24 - PubMed
  71. PLoS One. 2012;7(6):e39725 - PubMed
  72. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15473-8 - PubMed
  73. J Exp Med. 2011 Sep 26;208(10):1931-5 - PubMed
  74. Nat Rev Genet. 2012 Sep;13(9):654-66 - PubMed
  75. J Clin Invest. 2012 Oct;122(10):3398-406 - PubMed
  76. Blood. 2009 Feb 19;113(8):1730-40 - PubMed
  77. Blood. 2007 Jan 15;109(2):674-82 - PubMed
  78. Stem Cells. 2014 Jun;32(6):1390-7 - PubMed

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