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Zaruba MT, Filli T, Rechenberg DK, et al. Intracanal Antibiotic Medication for Sustained Root Surface Disinfection-A Laboratory Evaluation. Open Dent J. 2015;9:396-401doi: 10.2174/1874210601509010396.
Zaruba, M. T., Filli, T., Rechenberg, D. K., Thurnheer, T., Attin, T., & Schmidlin, P. R. (2015). Intracanal Antibiotic Medication for Sustained Root Surface Disinfection-A Laboratory Evaluation. The open dentistry journal, 9396-401. https://doi.org/10.2174/1874210601509010396
Zaruba, Markus Tobias Winfried, et al. "Intracanal Antibiotic Medication for Sustained Root Surface Disinfection-A Laboratory Evaluation." The open dentistry journal vol. 9 (2015): 396-401. doi: https://doi.org/10.2174/1874210601509010396
Zaruba MT, Filli T, Rechenberg DK, Thurnheer T, Attin T, Schmidlin PR. Intracanal Antibiotic Medication for Sustained Root Surface Disinfection-A Laboratory Evaluation. Open Dent J. 2015 Dec 11;9:396-401. doi: 10.2174/1874210601509010396. eCollection 2015. PMID: 26966464; PMCID: PMC4765508.
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Open Dent J. 2015 Dec 11;9:396-401. doi: 10.2174/1874210601509010396. eCollection 2015.

Intracanal Antibiotic Medication for Sustained Root Surface Disinfection-A Laboratory Evaluation.

The open dentistry journal

Markus Tobias Winfried Zaruba, Tilla Filli, Dan-Krister Rechenberg, Thomas Thurnheer, Thomas Attin, Patrick Roger Schmidlin

Affiliations

  1. Clinic of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Switzerland.
  2. Section for Oral Microbiology and Immunology, Institute of Oral Biology, Center of Dental Medicine, University of Zurich, Switzerland.

PMID: 26966464 PMCID: PMC4765508 DOI: 10.2174/1874210601509010396

Abstract

PURPOSE: To measure the release of an antibiotic mixture of ciprofloxacin, cerfuroxim and metronidazole (TreVitaMix, TVM) through human dentine and to assess the growth inhibition of Fusobacterium nucleatum.

MATERIAL AND METHODS: Twenty-four extracted human incisors were scaled and endodontically treated. Root canals were either filled with antibiotic tri-mixture (TVM) or with the carrier material alone (propylene glycol, PG) and were coronally and apically sealed with a flowable composite. Transradicular medicament release was spectrophotometrically measured at 277 nm in simulated body fluid for up to 21 days. In a second part, an agar diffusion assay (F. nucleatum) with representative TVM concentrations as determined in the first part was performed to study the growth inhibition. Samples were anaerobical incubated for 48 h and inhibition zones were measured.

RESULTS: TVM was spectrophotometrically detectable in the immersion solution and released in decreasing concentrations up to 21 days (222.5 ± 65.2 mg/ml at day 1 and 35.1 ± 15.6 mg/ml at day 21). In addition, inhibition zones were shown in the agar diffusion assay at representative TVM concentrations. The carrier material showed no antibacterial effect.

CONLUSION: TVM showed the potential to penetrate through dentine and to inhibit bacterial growth. Therefore, it might have the potential to disinfect the outer root surface in perio-endo lesions, but further research is needed to confirm these observations.

Keywords: Agar diffusion; TreVitaMix.; bacteria; dentine; perio-endo lesion

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