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Reddy KP, Bajwa EK, Parker RA, et al. Relationship Between Upper Respiratory Tract Influenza Test Result and Clinical Outcomes Among Critically Ill Influenza Patients. Open Forum Infect Dis. 2016;3(1):ofw023doi: 10.1093/ofid/ofw023.
Reddy, K. P., Bajwa, E. K., Parker, R. A., Onderdonk, A. B., & Walensky, R. P. (2016). Relationship Between Upper Respiratory Tract Influenza Test Result and Clinical Outcomes Among Critically Ill Influenza Patients. Open forum infectious diseases, 3(1), ofw023. https://doi.org/10.1093/ofid/ofw023
Reddy, Krishna P, et al. "Relationship Between Upper Respiratory Tract Influenza Test Result and Clinical Outcomes Among Critically Ill Influenza Patients." Open forum infectious diseases vol. 3,1 (2016): ofw023. doi: https://doi.org/10.1093/ofid/ofw023
Reddy KP, Bajwa EK, Parker RA, Onderdonk AB, Walensky RP. Relationship Between Upper Respiratory Tract Influenza Test Result and Clinical Outcomes Among Critically Ill Influenza Patients. Open Forum Infect Dis. 2016 Mar 08;3(1):ofw023. doi: 10.1093/ofid/ofw023. eCollection 2016 Jan. PMID: 26966696; PMCID: PMC4784015.
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Open Forum Infect Dis. 2016 Mar 08;3(1):ofw023. doi: 10.1093/ofid/ofw023. eCollection 2016 Jan.

Relationship Between Upper Respiratory Tract Influenza Test Result and Clinical Outcomes Among Critically Ill Influenza Patients.

Open forum infectious diseases

Krishna P Reddy, Ednan K Bajwa, Robert A Parker, Andrew B Onderdonk, Rochelle P Walensky

Affiliations

  1. Medical Practice Evaluation Center; Division of Pulmonary and Critical Care Medicine; Division of Pulmonary and Critical Care Medicine; Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center; Harvard Medical School, Boston, Massachusetts.
  2. Division of Pulmonary and Critical Care Medicine; Harvard Medical School, Boston, Massachusetts.
  3. Medical Practice Evaluation Center; Division of General Internal Medicine; Biostatistics Center; Harvard Medical School, Boston, Massachusetts.
  4. Department of Pathology; Harvard Medical School, Boston, Massachusetts.
  5. Medical Practice Evaluation Center; Division of General Internal Medicine; Division of Infectious Disease, Massachusetts General Hospital; Division of Infectious Disease, Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts.

PMID: 26966696 PMCID: PMC4784015 DOI: 10.1093/ofid/ofw023

Abstract

Among critically ill patients with lower respiratory tract (LRT)-confirmed influenza, we retrospectively observed worse 28-day clinical outcomes in upper respiratory tract (URT)-negative versus URT-positive subjects. This finding may reflect disease progression and highlights the need for influenza testing of both URT and LRT specimens to improve diagnostic yield and possibly inform prognosis.

Keywords: critically ill; influenza diagnosis; lower respiratory tract; upper respiratory tract

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