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Madias C, Garlitski AC, Kalin J, et al. L-Type Calcium Channels Do Not Play a Critical Role in Chest Blow Induced Ventricular Fibrillation: Commotio Cordis. Cardiol Res Pract. 2016;2016:5191683doi: 10.1155/2016/5191683.
Madias, C., Garlitski, A. C., Kalin, J., & Link, M. S. (2016). L-Type Calcium Channels Do Not Play a Critical Role in Chest Blow Induced Ventricular Fibrillation: Commotio Cordis. Cardiology research and practice, 20165191683. https://doi.org/10.1155/2016/5191683
Madias, Christopher, et al. "L-Type Calcium Channels Do Not Play a Critical Role in Chest Blow Induced Ventricular Fibrillation: Commotio Cordis." Cardiology research and practice vol. 2016 (2016): 5191683. doi: https://doi.org/10.1155/2016/5191683
Madias C, Garlitski AC, Kalin J, Link MS. L-Type Calcium Channels Do Not Play a Critical Role in Chest Blow Induced Ventricular Fibrillation: Commotio Cordis. Cardiol Res Pract. 2016;2016:5191683. doi: 10.1155/2016/5191683. Epub 2016 Jan 26. PMID: 26925288; PMCID: PMC4746352.
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Cardiol Res Pract. 2016;2016:5191683. doi: 10.1155/2016/5191683. Epub 2016 Jan 26.

L-Type Calcium Channels Do Not Play a Critical Role in Chest Blow Induced Ventricular Fibrillation: Commotio Cordis.

Cardiology research and practice

Christopher Madias, Ann C Garlitski, John Kalin, Mark S Link

Affiliations

  1. Cardiac Electrophysiology Service, Section of Cardiology, Rush University Medical Center, Chicago, IL, USA.
  2. Cardiac Arrhythmia Center, Division of Cardiology, Tufts Medical Center (TMC), P.O. Box 197, 800 Washington Street, Boston, MA 02111, USA.

PMID: 26925288 PMCID: PMC4746352 DOI: 10.1155/2016/5191683

Abstract

Background. In a commotio cordis swine model, ventricular fibrillation (VF) can be induced by a ball blow to the chest believed secondary to activation of mechanosensitive ion channels. The purpose of the current study is to evaluate whether stretch induced activation of the L-type calcium channel may cause intracellular calcium overload and underlie the VF in commotio cordis. Method and Results. Anesthetized juvenile swine received 6 chest wall strikes with a 17.9 m/s lacrosse ball timed to the vulnerable period for VF induction. Animals were randomized to IV verapamil (n = 6) or placebo (n = 6). There was no difference in the observed frequency of VF between verapamil (19/26: 73%) and placebo (20/36: 56%) treated animals (p = 0.16). There was also no significant difference in the combined endpoint of VF or nonsustained VF (21/26: 81% in verapamil versus 24/36: 67% in controls, p = 0.22). Conclusions. In this experimental model of commotio cordis, verapamil did not prevent VF induction. Thus, in commotio cordis it is unlikely that stretch activation of the L-type calcium channel with resultant intracellular calcium overload plays a prominent role.

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