Display options
Cite
Lu CX, Qiu T, Tong HS, et al. Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis. Exp Ther Med. 2016;11(3):1077-1084doi: 10.3892/etm.2016.3000.
Lu, C. X., Qiu, T., Tong, H. S., Liu, Z. F., Su, L., & Cheng, B. (2016). Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis. Experimental and therapeutic medicine, 11(3), 1077-1084. https://doi.org/10.3892/etm.2016.3000
Lu, Cheng-Xiang, et al. "Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis." Experimental and therapeutic medicine vol. 11,3 (2016): 1077-1084. doi: https://doi.org/10.3892/etm.2016.3000
Lu CX, Qiu T, Tong HS, Liu ZF, Su L, Cheng B. Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis. Exp Ther Med. 2016 Mar;11(3):1077-1084. doi: 10.3892/etm.2016.3000. Epub 2016 Jan 15. PMID: 26998040; PMCID: PMC4774448.
Copy Download .nbib Format: NLM
Share it on

Exp Ther Med. 2016 Mar;11(3):1077-1084. doi: 10.3892/etm.2016.3000. Epub 2016 Jan 15.

Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis.

Experimental and therapeutic medicine

Cheng-Xiang Lu, Ting Qiu, Hua-Sheng Tong, Zhi-Feng Liu, Lei Su, Biao Cheng

Affiliations

  1. Department of Intensive Care Unit, Affiliated General Hospital of Guangzhou Military Command of Southern Medical University, Guangzhou, Guangdong 510515, P.R. China; Department of Intensive Care Unit, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, P.R. China.
  2. Department of Neurology, Zhongshan Hospital Xiamen University, Xiamen, Fujian 361004, P.R. China.
  3. Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China.
  4. Department of Intensive Care Unit, Affiliated General Hospital of Guangzhou Military Command of Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
  5. Department of Plastic Surgery, Affiliated General Hospital of Guangzhou Military Command of Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

PMID: 26998040 PMCID: PMC4774448 DOI: 10.3892/etm.2016.3000

Abstract

Septic encephalopathy (SE) is a diffuse cerebral dysfunction resulting from a systemic inflammatory response, and is associated with an increased risk of mortality. The pathogenesis of SE is complex and multifactorial, but unregulated immune imbalance may be an important factor. The current retrospective study examined the clinical data of 86 patients with severe sepsis who were admitted to the Intensive Care Unit at Zhongshan Hospital, Xiamen University (Xiamen, China) from January, 2014 to January, 2015. The patients were assigned to SE and non-SE patient groups according to the presence or absence of SE. The proportion of T-lymphocyte subsets and natural killer (NK) cells in the immune cell population, representing the function of the immune system, were analyzed for their association with SE and compared with other clinical predictors and biomarkers. The incidence of SE in the patients was 39.5%, and this group demonstrated higher mortality rates (38 vs. 10% in non-SE patients; P=0.001). Univariate analysis revealed that the SE patients reported a lower percentage of cluster of differentiation 4

Keywords: CD4+ T-lymphocytes; immune imbalance; mortality; natural killer cell; predictor; regression; septic encephalopathy; severe sepsis

References

  1. Crit Care Med. 1990 Aug;18(8):801-6 - PubMed
  2. Am J Respir Crit Care Med. 2007 May 1;175(9):935-42 - PubMed
  3. J Neurosci. 2005 Apr 20;25(16):4082-90 - PubMed
  4. Crit Care Med. 2000 May;28(5):1310-5 - PubMed
  5. Am J Respir Crit Care Med. 2001 Feb;163(2):316-21 - PubMed
  6. Crit Care. 2010;14(3):R81 - PubMed
  7. Transl Med UniSa. 2012 Jan 18;2:20-7 - PubMed
  8. J Trauma. 1993 Dec;35(6):844-9 - PubMed
  9. J Immunol. 2001 Jun 1;166(11):6952-63 - PubMed
  10. Chin Med J (Engl). 2012 Mar;125(5):828-31 - PubMed
  11. Crit Care. 2011;15(5):R243 - PubMed
  12. Rev Bras Psiquiatr. 2014 Sep;36(3):251-8 - PubMed
  13. Blood. 2004 Sep 15;104(6):1778-83 - PubMed
  14. Crit Care Med. 1999 Apr;27(4):733-40 - PubMed
  15. Crit Care Med. 2001 Mar;29(3):618-22 - PubMed
  16. Crit Care Med. 1991 Jun;19(6):753-7 - PubMed
  17. Shock. 2001 Aug;16(2):83-96 - PubMed
  18. Chest. 2008 Aug;134(2):281-7 - PubMed
  19. Intensive Care Med. 1999 Jan;25(1):106-9 - PubMed
  20. Br J Anaesth. 2007 Oct;99(4):518-21 - PubMed
  21. J Intensive Care Med. 2011 Mar-Apr;26(2):125-32 - PubMed
  22. Intensive Care Med. 2004 Aug;30(8):1544-51 - PubMed
  23. JAMA. 2011 Dec 21;306(23):2594-605 - PubMed
  24. JAMA. 1996 Feb 14;275(6):470-3 - PubMed
  25. J Med Microbiol. 2001 Sep;50(9):812-21 - PubMed
  26. Neurol Res. 1998 Mar;20(2):100-6 - PubMed
  27. Intensive Care Med. 2003 Apr;29(4):530-8 - PubMed
  28. Crit Care Med. 2007 Oct;35(10):2408-16 - PubMed
  29. Neurol Clin. 2011 Nov;29(4):837-82 - PubMed
  30. Int J Infect Dis. 2012 Mar;16(3):e182-6 - PubMed
  31. Intensive Care Med. 2002 Mar;28(3):293-8 - PubMed
  32. APMIS. 1995 Apr;103(4):261-6 - PubMed
  33. PLoS One. 2014 Dec 26;9(12):e115094 - PubMed
  34. Intensive Care Med. 2007 Jun;33(6):941-50 - PubMed
  35. Nat Rev Immunol. 2008 Oct;8(10):776-87 - PubMed
  36. Neurochem Res. 2009 Jul;34(7):1289-92 - PubMed
  37. J Clin Invest. 1955 Jan;34(1):126-31 - PubMed
  38. Intensive Care Med. 2003 May;29(5):667-8 - PubMed
  39. Crit Care. 2006;10(6):238 - PubMed
  40. Prog Neurobiol. 2002 Jun;67(2):161-72 - PubMed
  41. CNS Neurol Disord Drug Targets. 2013 Sep;12(6):720-5 - PubMed
  42. J Clin Endocrinol Metab. 2000 Jan;85(1):42-7 - PubMed
  43. Crit Care Med. 1992 Jun;20(6):724-6 - PubMed
  44. Front Cell Neurosci. 2015 Feb 02;9:28 - PubMed
  45. J Neuroinflammation. 2012 Jul 02;9:155 - PubMed
  46. Am J Surg. 2005 Feb;189(2):219-22 - PubMed
  47. Blood. 1999 Mar 1;93(5):1464-76 - PubMed
  48. Glia. 2001 Nov;36(2):191-9 - PubMed
  49. Scand J Immunol. 1998 Jan;47(1):69-75 - PubMed
  50. Br J Surg. 1993 Feb;80(2):205-9 - PubMed
  51. Biochem Biophys Res Commun. 2003 Sep 5;308(4):840-6 - PubMed
  52. Crit Care Med. 2006 Jul;34(7):1967-74 - PubMed
  53. J Neuroimmunol. 2003 Jan;134(1-2):166-78 - PubMed
  54. Crit Care Med. 2013 Feb;41(2):580-637 - PubMed
  55. Crit Care Med. 1996 Feb;24(2):298-305 - PubMed
  56. EMBO J. 2014 Jan 7;33(1):7-22 - PubMed
  57. JAMA. 2008 Jul 23;300(4):413-22 - PubMed

Publication Types