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Hashemi SM, Fazeli SA, Vahedi A, et al. Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report. Mol Clin Oncol. 2015;4(3):436-440doi: 10.3892/mco.2015.715.
Hashemi, S. M., Fazeli, S. A., Vahedi, A., & Golabchifard, R. (2016). Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report. Molecular and clinical oncology, 4(3), 436-440. https://doi.org/10.3892/mco.2015.715
Hashemi, Seyed Mehdi, et al. "Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report." Molecular and clinical oncology vol. 4,3 (2016): 436-440. doi: https://doi.org/10.3892/mco.2015.715
Hashemi SM, Fazeli SA, Vahedi A, Golabchifard R. Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report. Mol Clin Oncol. 2016 Mar;4(3):436-440. doi: 10.3892/mco.2015.715. Epub 2015 Dec 18. PMID: 26998300; PMCID: PMC4774570.
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Mol Clin Oncol. 2016 Mar;4(3):436-440. doi: 10.3892/mco.2015.715. Epub 2015 Dec 18.

Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report.

Molecular and clinical oncology

Seyed Mehdi Hashemi, Seyed Amirhossein Fazeli, Abdolbaset Vahedi, Reza Golabchifard

Affiliations

  1. Division of Hematology and Medical Oncology, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran; Division of Hematology and Medical Oncology, Department of Internal Medicine, Ali-Ebne-Abitaleb Hospital, Zahedan, Iran.
  2. Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
  3. Students' Scientific Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

PMID: 26998300 PMCID: PMC4774570 DOI: 10.3892/mco.2015.715

Abstract

Sweet's syndrome is a neutrophilic dermatosis characterised by sudden onset of fever, neutrophilia, erythematous skin rashes and neutrophilic infiltration of the dermis. Subcutaneous Sweet's syndrome, or Sweet's panniculitis, is an uncommon variant of the classic syndrome, with hypodermal neutrophilic infiltration. The association of Sweet's syndrome with various malignancies has been reported. The most common underlying hematological malignancies are of myeloid origin; however, there have been several reports of the classic Sweet's syndrome in patients with a lymphoproliferative disorder, although the association of subcutaneous Sweet's syndrome with lymphoproliferative disorders has not been well-documented thus far. Herein, we present the case of a 48-year-old man with a 2-year history of chronic lymphocytic leukemia who developed fever and skin rashes, without any evidence of a relapse. The clinical and pathological investigation resulted in the diagnosis of subcutaneous Sweet's syndrome. The patient exhibited no significant response to conventional therapeutic measures; however, following two subsequent doses of rituximab, his general condition and skin rash improved. The follow-up skin biopsy demonstrated dermal neutrophilic infiltrations in conjunction with prior mixed lobular and septal panniculitis, suggesting evolution of subcutaneous Sweet's syndrome to its classic form. To the best of our knowledge, this is one of the first reports of rituximab as a novel biological treatment for Sweet's syndrome. However, further randomized trials are required to evaluate the efficacy and safety of such biological therapies for Sweet's syndrome.

Keywords: chronic lymphocytic leukemia; panniculitis; refractory; rituximab; subcutaneous Sweet's syndrome

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