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Deshayes S, Bouvier N, Chatelet V, et al. Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab. Transpl Infect Dis. 2016;18(3):461-465doi: 10.1111/tid.12522.
Deshayes, S., Bouvier, N., Chatelet, V., Hurault de Ligny, B., Dargère, S., Bonhomme, J., & Béchade, C. (2016). Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab. Transplant infectious disease : an official journal of the Transplantation Society, 18(3), 461-465. https://doi.org/10.1111/tid.12522
Deshayes, S, et al. "Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab." Transplant infectious disease : an official journal of the Transplantation Society vol. 18,3 (2016): 461-465. doi: https://doi.org/10.1111/tid.12522
Deshayes S, Bouvier N, Chatelet V, Hurault de Ligny B, Dargère S, Bonhomme J, Béchade C. Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab. Transpl Infect Dis. 2016 Jun;18(3):461-465. doi: 10.1111/tid.12522. Epub 2016 Apr 07. PMID: 26929435.
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Transpl Infect Dis. 2016 Jun;18(3):461-465. doi: 10.1111/tid.12522. Epub 2016 Apr 07.

Severe cryptococcal-associated neurological immune reconstitution inflammatory syndrome in a renal transplant recipient treated with adalimumab.

Transplant infectious disease : an official journal of the Transplantation Society

S Deshayes, N Bouvier, V Chatelet, B Hurault de Ligny, S Dargère, J Bonhomme, C Béchade

Affiliations

  1. Department of Internal Medicine, CHU de Caen, Caen, France.
  2. Department of Nephrology, CHU de Caen, Caen, France.
  3. Department of Infectious Diseases, CHU de Caen, Caen, France.
  4. Department of Microbiology, CHU de Caen, Caen, France.

PMID: 26929435 DOI: 10.1111/tid.12522

Abstract

Cryptococcosis is a major concern in organ transplant recipients. A decrease in immunosuppressants following the initiation of antifungal therapy is currently recommended, but can occasionally be complicated by the onset of immune reconstitution inflammatory syndrome (IRIS). We report on a case of cryptococcosis in a kidney transplant recipient, compounded by severe neurological IRIS, the outcome of which was unfavorable despite the use of anti-tumor necrosis factor-alpha monoclonal antibodies.

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Keywords: Cryptococcus neoformans ; anti-tumor necrosis factor-alpha monoclonal antibody; cryptococcosis; immune reconstitution inflammatory syndrome; kidney transplantation

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