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Wang ZR, Li YX, Lei HY, et al. Regulating effect of activated NF-κB on edema induced by traumatic brain injury of rats. Asian Pac J Trop Med. 2016;9(3):274-7doi: 10.1016/j.apjtm.2016.01.027.
Wang, Z. R., Li, Y. X., Lei, H. Y., Yang, D. Q., Wang, L. Q., & Luo, M. Y. (2016). Regulating effect of activated NF-κB on edema induced by traumatic brain injury of rats. Asian Pacific journal of tropical medicine, 9(3), 274-7. https://doi.org/10.1016/j.apjtm.2016.01.027
Wang, Zi-Ran, et al. "Regulating effect of activated NF-κB on edema induced by traumatic brain injury of rats." Asian Pacific journal of tropical medicine vol. 9,3 (2016): 274-7. doi: https://doi.org/10.1016/j.apjtm.2016.01.027
Wang ZR, Li YX, Lei HY, Yang DQ, Wang LQ, Luo MY. Regulating effect of activated NF-κB on edema induced by traumatic brain injury of rats. Asian Pac J Trop Med. 2016 Mar;9(3):274-7. doi: 10.1016/j.apjtm.2016.01.027. Epub 2016 Jan 15. PMID: 26972401.
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Asian Pac J Trop Med. 2016 Mar;9(3):274-7. doi: 10.1016/j.apjtm.2016.01.027. Epub 2016 Jan 15.

Regulating effect of activated NF-κB on edema induced by traumatic brain injury of rats.

Asian Pacific journal of tropical medicine

Zi-Ran Wang, Yu-Xin Li, Hong-Yan Lei, Dai-Qun Yang, Li-Quan Wang, Ming-Yu Luo

Affiliations

  1. Department of Cerebral Surgery, Linyi People's Hospital, Shandong 276000, China.
  2. Department of Cerebral Surgery, Linyi People's Hospital, Shandong 276000, China. Electronic address: [email protected].

PMID: 26972401 DOI: 10.1016/j.apjtm.2016.01.027

Abstract

OBJECTIVE: To observe the effect of nuclear transcription factor-κB (NF-κB) on cerebral edema in rats with traumatic brain injury (TBI).

METHODS: Male SD rats with fluid percussion injury (FPI) were selected. After separation and culture, rats' astrocytes all suffered FPI. The expression of NF-κB and the water content were detected at the animal and cellular levels, while the activity of NOX was evaluated at the cellular level.

RESULTS: According to the results, the positive expression of NF-κB and expression of mRNA were significantly increased and the water content was increased for rats after TBI, while NF-κB inhibitor BAY11-7082 could significantly reduce the effect of TBI. 1 and 3 h after FPI of astrocytes, the activation of NF-κB was increased and BAY 11-7082 could significantly improve the injury-induced swelling of astrocytes. After the injury of astrocytes, the activity of NOX was also increased, while BAY 11-7082 could reduce the activity of NOX.

CONCLUSIONS: The results show that the activation of NF-κB in astrocytes is a key factor in the process of cerebral edema after TBI of rats.

Copyright © 2016 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved.

Keywords: Astrocytes; Nuclear transcription factor-κB; Rat; Traumatic brain injury

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