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Nadkerny PV, Ravishankar PL, Pramod V, et al. A comparative evaluation of the efficacy of probiotic and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A randomized controlled clinical study. J Indian Soc Periodontol. 2015;19(6):633-9doi: 10.4103/0972-124X.168491.
Nadkerny, P. V., Ravishankar, P. L., Pramod, V., Agarwal, L. A., & Bhandari, S. (2015). A comparative evaluation of the efficacy of probiotic and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A randomized controlled clinical study. Journal of Indian Society of Periodontology, 19(6), 633-9. https://doi.org/10.4103/0972-124X.168491
Nadkerny, Purnima Vidyesh, et al. "A comparative evaluation of the efficacy of probiotic and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A randomized controlled clinical study." Journal of Indian Society of Periodontology vol. 19,6 (2015): 633-9. doi: https://doi.org/10.4103/0972-124X.168491
Nadkerny PV, Ravishankar PL, Pramod V, Agarwal LA, Bhandari S. A comparative evaluation of the efficacy of probiotic and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A randomized controlled clinical study. J Indian Soc Periodontol. 2015 Nov-Dec;19(6):633-9. doi: 10.4103/0972-124X.168491. PMID: 26941513; PMCID: PMC4753707.
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J Indian Soc Periodontol. 2015 Nov-Dec;19(6):633-9. doi: 10.4103/0972-124X.168491.

A comparative evaluation of the efficacy of probiotic and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A randomized controlled clinical study.

Journal of Indian Society of Periodontology

Purnima Vidyesh Nadkerny, Potluri Leela Ravishankar, Virupapuram Pramod, Lavanya Abhay Agarwal, Saurabh Bhandari

Affiliations

  1. Department of Periodontics, New Horizon Dental College and Research Institute, Sakri, Bilaspur, Chhattisgarh, India.

PMID: 26941513 PMCID: PMC4753707 DOI: 10.4103/0972-124X.168491

Abstract

BACKGROUND: The aim of our clinical trial was to assess and compare the antiplaque and anti-inflammatory potential of a probiotic mouthwash with 0.2% chlorhexidine and saline.

MATERIALS AND METHODS: A randomized parallel group study was designed for a period of 4 weeks on 45 systemically healthy subjects between 20 and 30 years having chronic gingivitis. The study population was divided into three groups. Group A - 15 subjects were advised experimental (probiotic) mouthwash. Group B - 15 subjects were advised positive control (chlorhexidine) mouthwash and Group C - 15 subjects into a negative control group (normal saline). Oral prophylaxis was done for all groups at baseline. After the proper oral hygiene instructions, all the three groups were instructed to rinse their mouth with 10 ml of their respective mouthrinse, undiluted for 1 min twice daily, 30 min after brushing. Clinical parameters such as plaque index (PI), gingival index (GI), and oral hygiene index simplified (OHI-S) were assessed at baseline, 2 weeks and 4 weeks, respectively.

RESULTS: At day 28, the PI, GI, and OHI-S were significantly reduced by all treatment modalities ranking probiotic and chlorhexidine is greater than saline.

CONCLUSION: The probiotic mouthrinses tested was effectively used as an adjunct to mechanical plaque control in the prevention of plaque and gingivitis. Thus, the probiotic mouthrinse has a great therapeutic potential.

Keywords: Chlorhexidine; gingivitis; mouthrinse; probiotic

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