Display options
Cite
Moustafa AA, Phillips J, Kéri S, et al. On the Complexity of Brain Disorders: A Symptom-Based Approach. Front Comput Neurosci. 2016;10:16doi: 10.3389/fncom.2016.00016.
Moustafa, A. A., Phillips, J., Kéri, S., Misiak, B., & Frydecka, D. (2016). On the Complexity of Brain Disorders: A Symptom-Based Approach. Frontiers in computational neuroscience, 1016. https://doi.org/10.3389/fncom.2016.00016
Moustafa, Ahmed A, et al. "On the Complexity of Brain Disorders: A Symptom-Based Approach." Frontiers in computational neuroscience vol. 10 (2016): 16. doi: https://doi.org/10.3389/fncom.2016.00016
Moustafa AA, Phillips J, Kéri S, Misiak B, Frydecka D. On the Complexity of Brain Disorders: A Symptom-Based Approach. Front Comput Neurosci. 2016 Feb 23;10:16. doi: 10.3389/fncom.2016.00016. eCollection 2016. PMID: 26941635; PMCID: PMC4763073.
Copy Download .nbib Format: NLM
Share it on

Front Comput Neurosci. 2016 Feb 23;10:16. doi: 10.3389/fncom.2016.00016. eCollection 2016.

On the Complexity of Brain Disorders: A Symptom-Based Approach.

Frontiers in computational neuroscience

Ahmed A Moustafa, Joseph Phillips, Szabolcs Kéri, Blazej Misiak, Dorota Frydecka

Affiliations

  1. School of Social Sciences and Psychology, Western Sydney UniversitySydney, NSW, Australia; Marcs Institute for Brain and Behavior, Western Sydney UniversitySydney, NSW, Australia.
  2. School of Social Sciences and Psychology, Western Sydney University Sydney, NSW, Australia.
  3. Nyírö Gyula Hospital, National Institute of Psychiatry and Addictions Budapest, Hungary.
  4. Department and Clinic of Psychiatry, Wroclaw Medical UniversityWroclaw, Poland; Department of Genetics, Wroclaw Medical UniversityWroclaw, Poland.
  5. Department and Clinic of Psychiatry, Wroclaw Medical University Wroclaw, Poland.

PMID: 26941635 PMCID: PMC4763073 DOI: 10.3389/fncom.2016.00016

Abstract

Mounting evidence shows that brain disorders involve multiple and different neural dysfunctions, including regional brain damage, change to cell structure, chemical imbalance, and/or connectivity loss among different brain regions. Understanding the complexity of brain disorders can help us map these neural dysfunctions to different symptom clusters as well as understand subcategories of different brain disorders. Here, we discuss data on the mapping of symptom clusters to different neural dysfunctions using examples from brain disorders such as major depressive disorder (MDD), Parkinson's disease (PD), schizophrenia, posttraumatic stress disorder (PTSD) and Alzheimer's disease (AD). In addition, we discuss data on the similarities of symptoms in different disorders. Importantly, computational modeling work may be able to shed light on plausible links between various symptoms and neural damage in brain disorders.

Keywords: Parkinson’s disease; brain disorders; functional connectivity; major depressive disorder; neurotransmitters; posttraumatic stress disorder; regional brain volume; schizophrenia

References

  1. Behav Brain Res. 2015 Apr 15;283:121-38 - PubMed
  2. Neurology. 2009 Jul 21;73(3):206-12 - PubMed
  3. Nature. 1997 Feb 13;385(6617):634-6 - PubMed
  4. Schizophr Bull. 2011 Jul;37(4):746-56 - PubMed
  5. Front Comput Neurosci. 2014 Jan 09;7:190 - PubMed
  6. Biol Psychiatry. 2010 Jul 1;68(1):17-24 - PubMed
  7. Schizophr Res. 2007 Jan;89(1-3):177-90 - PubMed
  8. Mov Disord. 2011 May;26(6):947-57 - PubMed
  9. Am J Psychiatry. 1999 May;156(5):675-82 - PubMed
  10. J Psychopharmacol. 2007 Jul;21(5):461-71 - PubMed
  11. Neuroreport. 2008 Jan 8;19(1):55-8 - PubMed
  12. BMJ Open. 2012 Jun 25;2(3):null - PubMed
  13. J Psychopharmacol. 2013 Oct;27(10):869-77 - PubMed
  14. Biol Psychiatry. 2015 Jan 15;77(2):95-105 - PubMed
  15. Arch Gen Psychiatry. 1988 Sep;45(9):789-96 - PubMed
  16. Lancet Neurol. 2011 Aug;10(8):734-44 - PubMed
  17. Brain Cogn. 2013 Feb;81(1):29-43 - PubMed
  18. Stress. 2015;18(4):484-9 - PubMed
  19. Front Syst Neurosci. 2015 Mar 25;9:42 - PubMed
  20. Mov Disord. 2000 Jan;15(1):84-94 - PubMed
  21. J Anxiety Disord. 2013 Oct;27(7):645-51 - PubMed
  22. Mov Disord. 2012 Nov;27(13):1679-82 - PubMed
  23. Arch Gen Psychiatry. 2002 Nov;59(11):1002-10 - PubMed
  24. Biol Psychiatry. 2003 Mar 15;53(6):502-10 - PubMed
  25. J Neurosci. 2000 Oct 15;20(20):7766-75 - PubMed
  26. Acta Neurol Scand Suppl. 2003;179:29-33 - PubMed
  27. J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):636-42 - PubMed
  28. Brain. 2012 Nov;135(Pt 11):3206-26 - PubMed
  29. J Clin Neurosci. 2010 Aug;17(8):984-7 - PubMed
  30. J Trauma Stress. 2007 Oct;20(5):713-25 - PubMed
  31. J Trauma Stress. 2014 Dec;27(6):717-20 - PubMed
  32. Mov Disord. 2007 Jul 30;22(10):1379-89; quiz 1523 - PubMed
  33. Brain. 2007 Sep;130(Pt 9):2367-74 - PubMed
  34. Schizophr Res. 2010 Sep;122(1-3):85-93 - PubMed
  35. Arch Gen Psychiatry. 2003 Jan;60(1):49-56 - PubMed
  36. Pharmacotherapy. 1996 Jan-Feb;16(1 Pt 2):11-4 - PubMed
  37. Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S123-5 - PubMed
  38. PLoS One. 2013;8(3):e58607 - PubMed
  39. Med Sci Monit. 2005 Mar;11(3):CR109-16 - PubMed
  40. Brain Cogn. 1993 Jul;22(2):213-29 - PubMed
  41. Schizophr Res. 2010 May;118(1-3):140-5 - PubMed
  42. J Alzheimers Dis. 2010;19(4):1401-8 - PubMed
  43. Dan Med Bull. 2000 Jun;47(3):151-67 - PubMed
  44. Am J Psychiatry. 2005 Dec;162(12):2233-45 - PubMed
  45. Brain. 2013 Dec;136(Pt 12):3671-81 - PubMed
  46. Psychiatry Res. 2011 Jun 30;188(1):13-7 - PubMed
  47. J Psychopharmacol. 2008 May;22(3):254-61 - PubMed
  48. J Clin Psychiatry. 2008;69 Suppl E1:4-7 - PubMed
  49. Behav Brain Res. 2015 Sep 15;291:147-54 - PubMed
  50. PLoS Comput Biol. 2014 Jun 12;10(6):e1003577 - PubMed
  51. Tremor Other Hyperkinet Mov (N Y). 2012;2:null - PubMed
  52. J Neurol Sci. 1982 Nov;56(2-3):343-56 - PubMed
  53. Schizophr Res. 2011 Apr;127(1-3):131-6 - PubMed
  54. Trends Neurosci. 1989 Oct;12(10):366-75 - PubMed
  55. Eur J Neurol. 2010 Apr;17 (4):626-30 - PubMed
  56. J Neurosci. 2002 May 1;22(9):3708-19 - PubMed
  57. Brain. 2010 Mar;133(Pt 3):923-40 - PubMed
  58. Biol Mood Anxiety Disord. 2013 Jun 19;3(1):12 - PubMed
  59. Neurosci Biobehav Rev. 2008;32(2):206-18 - PubMed
  60. J Neurol Neurosurg Psychiatry. 2010 Feb;81(2):177-84 - PubMed
  61. Arch Gen Psychiatry. 1992 Dec;49(12 ):959-65 - PubMed
  62. Brain. 2014 Dec;137(Pt 12):3223-34 - PubMed
  63. Biol Psychiatry. 2009 Sep 15;66(6):603-13 - PubMed
  64. N Engl J Med. 1988 Apr 7;318(14):876-80 - PubMed
  65. Am J Alzheimers Dis Other Demen. 2009 Apr-May;24(2):95-121 - PubMed
  66. Ann N Y Acad Sci. 1999 Jun 29;877:614-37 - PubMed
  67. Front Neuroanat. 2010 Dec 10;4:133 - PubMed
  68. J Neurosci. 2012 Nov 21;32(47):16541-51 - PubMed
  69. Brain. 2013 Mar;136(Pt 3):696-709 - PubMed
  70. Exp Neurol. 2005 Mar;192(1):73-8 - PubMed
  71. Curr Opin Neurobiol. 1995 Apr;5(2):169-77 - PubMed
  72. Brain Cogn. 2013 Jul;82(2):137-45 - PubMed
  73. J Voice. 2011 Jan;25(1):76-82 - PubMed
  74. CNS Spectr. 2008 Jul;13(7):561-5 - PubMed
  75. Transl Neurodegener. 2012 Jan 13;1(1):4 - PubMed
  76. Eur Neuropsychopharmacol. 2002 Dec;12 (6):527-44 - PubMed
  77. J Geriatr Psychiatry Neurol. 2010 Mar;23(1):35-41 - PubMed
  78. Kathmandu Univ Med J (KUMJ). 2006 Apr-Jun;4(2):152-60 - PubMed
  79. Acta Psychiatr Scand. 2007 Feb;115(2):93-100 - PubMed
  80. N Engl J Med. 1997 Sep 18;337(12):809-15 - PubMed
  81. Front Psychiatry. 2015 Mar 10;6:34 - PubMed
  82. Brain. 2005 Jun;128(Pt 6):1314-22 - PubMed
  83. J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):53-63 - PubMed
  84. Prog Neurobiol. 2010 Nov;92(3):345-69 - PubMed
  85. J Clin Psychiatry. 1994 May;55 Suppl:22-8 - PubMed
  86. Nat Neurosci. 2002 Nov;5(11):1242-7 - PubMed
  87. Eur J Neurosci. 2006 May;23(9):2395-403 - PubMed
  88. Br J Psychiatry. 1995 Jan;166(1):19-28 - PubMed
  89. Brain Struct Funct. 2008 Sep;213(1-2):93-118 - PubMed
  90. Arch Clin Neuropsychol. 2006 Jan;21(1):15-21 - PubMed
  91. Eur Psychiatry. 2001 Sep;16(6):354-61 - PubMed
  92. Ann Neurol. 2011 Feb;69(2):269-81 - PubMed
  93. Drugs. 1990 Nov;40(5):722-47 - PubMed
  94. J Neurol. 2000 Sep;247 Suppl 5:V33-48 - PubMed
  95. Schizophr Bull. 2014 Jul;40 Suppl 4:S295-304 - PubMed
  96. Can J Psychiatry. 1995 Feb;40(1):21-6 - PubMed
  97. Neurosci Biobehav Rev. 2015 Aug;55:247-67 - PubMed
  98. Science. 2007 Nov 23;318(5854):1309-12 - PubMed
  99. Philos Trans R Soc Lond B Biol Sci. 1996 Oct 29;351(1346):1515-27 - PubMed
  100. Am J Psychiatry. 2004 Nov;161(11):1957-66 - PubMed
  101. Front Neurol. 2014 Aug 18;5:157 - PubMed
  102. J Affect Disord. 2014 Feb;155:35-41 - PubMed
  103. Mov Disord. 2012 Mar;27(3):364-71 - PubMed
  104. PLoS One. 2012;7(7):e41598 - PubMed
  105. J Int Neuropsychol Soc. 2011 Nov;17(6):1058-66 - PubMed
  106. Biol Psychiatry. 2013 Jul 1;74(1):40-7 - PubMed
  107. Am J Psychiatry. 2000 Jan;157(1):16-25 - PubMed
  108. Neuropsychopharmacology. 2012 Aug;37(9):2031-46 - PubMed
  109. Psychopharmacology (Berl). 2004 Nov;176(3-4):312-9 - PubMed
  110. J Cogn Neurosci. 2012 Feb;24(2):351-66 - PubMed
  111. MD Comput. 1997 May-Jun;14(3):181-91 - PubMed
  112. Front Syst Neurosci. 2010 Sep 20;4:null - PubMed
  113. Biol Psychiatry. 2014 May 1;75(9):711-22 - PubMed
  114. Neuroimage Clin. 2014 Oct 16;6:463-74 - PubMed
  115. Am J Psychiatry. 1996 Feb;153(2):183-90 - PubMed
  116. Arch Gen Psychiatry. 1999 Dec;56(12 ):1117-23 - PubMed
  117. J Cogn Neurosci. 2003 Feb 15;15(2):185-93 - PubMed
  118. Mov Disord. 2012 Nov;27(13):1644-51 - PubMed
  119. Brain. 2015 Jun;138(Pt 6):1658-66 - PubMed
  120. Depress Anxiety. 2002;16(1):4-13 - PubMed
  121. CNS Drugs. 2006;20(5):389-409 - PubMed
  122. Annu Rev Pharmacol Toxicol. 2001;41:237-60 - PubMed
  123. Mov Disord. 2009 Jul 30;24(10):1437-44 - PubMed
  124. Int J Geriatr Psychiatry. 2009 Aug;24(8):885-93 - PubMed
  125. J Neural Transm (Vienna). 2007 Mar;114(3):331-5 - PubMed
  126. Cogn Behav Neurol. 2009 Jun;22(2):89-94 - PubMed
  127. Mov Disord. 1998;13 Suppl 3:2-23 - PubMed
  128. Ann Neurol. 1986 Feb;19(2):139-43 - PubMed
  129. Curr Opin Neurol. 2009 Aug;22(4):387-93 - PubMed
  130. BMJ. 1995 Mar 11;310(6980):627-31 - PubMed
  131. Front Aging Neurosci. 2015 Feb 03;7:6 - PubMed
  132. Neurology. 2001 Jun 26;56(12 ):1712-21 - PubMed
  133. J Psychiatr Res. 2008 Sep;42(11):930-7 - PubMed
  134. J Neurol. 2002 Feb;249(2):138-45 - PubMed
  135. PLoS One. 2011 Mar 18;6(3):e17846 - PubMed
  136. Arch Gen Psychiatry. 2010 Oct;67(10):1002-11 - PubMed
  137. Eur Psychiatry. 2007 Sep;22(6):371-9 - PubMed
  138. J Biomed Biotechnol. 2012;2012:259349 - PubMed
  139. Rev Neurol. 2002 Oct 16-31;35(8):777-83 - PubMed
  140. World Psychiatry. 2003 Oct;2(3):166-71 - PubMed
  141. JAMA Neurol. 2013 Oct;70(10):1325-9 - PubMed
  142. Cogn Neuropsychiatry. 2004 Feb-May;9(1-2):107-23 - PubMed
  143. US Neurol. 2011 Nov 1;7(2):100-108 - PubMed
  144. J Clin Invest. 2014 Mar;124(3):1340-9 - PubMed
  145. Psychiatry Res. 2010 Jul 30;178(2):260-5 - PubMed
  146. Biol Psychiatry. 2013 Jul 15;74(2):122-9 - PubMed
  147. Am J Psychiatry. 2015 Feb 1;172(2):139-53 - PubMed
  148. Trends Cogn Sci. 2002 Dec 1;6(12):505-510 - PubMed
  149. J Individ Psychol. 1974 May;30(1):98-113 - PubMed
  150. Rev Neurosci. 2013;24(4):415-29 - PubMed
  151. Brain Cogn. 2001 Jun-Jul;46(1-2):86-90 - PubMed
  152. Psychol Rev. 1995 Jul;102(3):419-57 - PubMed
  153. Dialogues Clin Neurosci. 2008;10(3):271-7 - PubMed
  154. Transl Psychiatry. 2012 Jun 12;2:e127 - PubMed
  155. Biol Cybern. 1979 Oct;34(3):137-50 - PubMed
  156. Compr Psychiatry. 1994 Jan-Feb;35(1):8-15 - PubMed
  157. Stress. 2012 Jan;15(1):31-44 - PubMed
  158. Am J Psychiatry. 1993 Jan;150(1):59-65 - PubMed
  159. Science. 2012 Nov 30;338(6111):1202-5 - PubMed
  160. Mov Disord. 2007 Jul 30;22(10):1503-6 - PubMed
  161. Neurobiol Aging. 2015 Mar;36(3):1245-52 - PubMed
  162. Ann Neurol. 2010 Nov;68(5):619-28 - PubMed
  163. PLoS One. 2013 Aug 27;8(8):e72508 - PubMed
  164. Neurology. 1993 Jul;43(7):1377-84 - PubMed

Publication Types