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Liu XL, Wang DD, Wang ZH, et al. Diuretic Properties and Chemical Constituent Studies on Stauntonia brachyanthera. Evid Based Complement Alternat Med. 2015;2015:432419doi: 10.1155/2015/432419.
Liu, X. L., Wang, D. D., Wang, Z. H., & Meng, d. a. . L. (2015). Diuretic Properties and Chemical Constituent Studies on Stauntonia brachyanthera. Evidence-based complementary and alternative medicine : eCAM, 2015432419. https://doi.org/10.1155/2015/432419
Liu, Xuan Li, et al. "Diuretic Properties and Chemical Constituent Studies on Stauntonia brachyanthera." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 432419. doi: https://doi.org/10.1155/2015/432419
Liu XL, Wang DD, Wang ZH, Meng da L. Diuretic Properties and Chemical Constituent Studies on Stauntonia brachyanthera. Evid Based Complement Alternat Med. 2015;2015:432419. doi: 10.1155/2015/432419. Epub 2015 Dec 29. PMID: 27057193; PMCID: PMC4709664.
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Evid Based Complement Alternat Med. 2015;2015:432419. doi: 10.1155/2015/432419. Epub 2015 Dec 29.

Diuretic Properties and Chemical Constituent Studies on Stauntonia brachyanthera.

Evidence-based complementary and alternative medicine : eCAM

Xuan Li Liu, Dan Dan Wang, Zi Hao Wang, Da Li Meng

Affiliations

  1. School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China.

PMID: 27057193 PMCID: PMC4709664 DOI: 10.1155/2015/432419

Abstract

The pharmacological evaluation demonstrated that the extracts from the stem of S. brachyanthera could significantly increase the outputs of urine of rats compared to those of furosemide treated group, and the effect could last for a longer period of time. The best effect appeared in the first two hours, which scientifically confirmed the diuretic effect of the plant. The comparative pharmacognosy study showed that the characters of the crude drugs of the stem of S. brachyanthera were similar to those of Akebia caulis. Further systemic work on its chemical constituents by chromatographic methods and NMR elucidations led to the isolation of 10 triterpenoids, 6 flavonoids, 4 lignanoids, and 3 phenylethanoid glycosides, whose structural types were much similar to those of A. quinata. Among them, 7 compounds were firstly reported in the genus of Stauntonia and calceolarioside B was the common characteristic constituent in both plants. From the similar pharmacognosy characters, pharmacological effects, and chemical constituents, it could be concluded that S. brachyanthera have a great possibility to be a succedaneum of Akebia caulis, whose supply is extremely short in recent years.

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