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Lee JY, Kim YH, Roh YH, et al. Intraoperative radiofrequency ablation for hepatocellular carcinoma in 112 patients with cirrhosis: a surgeon's view. Ann Surg Treat Res. 2016;90(3):147-56doi: 10.4174/astr.2016.90.3.147.
Lee, J. Y., Kim, Y. H., Roh, Y. H., Roh, K. B., Kim, K. W., Kang, S. H., Baek, Y. H., Lee, S. W., Han, S. Y., Kwon, H. J., & Cho, J. H. (2016). Intraoperative radiofrequency ablation for hepatocellular carcinoma in 112 patients with cirrhosis: a surgeon's view. Annals of surgical treatment and research, 90(3), 147-56. https://doi.org/10.4174/astr.2016.90.3.147
Lee, Jung Yeon, et al. "Intraoperative radiofrequency ablation for hepatocellular carcinoma in 112 patients with cirrhosis: a surgeon's view." Annals of surgical treatment and research vol. 90,3 (2016): 147-56. doi: https://doi.org/10.4174/astr.2016.90.3.147
Lee JY, Kim YH, Roh YH, Roh KB, Kim KW, Kang SH, Baek YH, Lee SW, Han SY, Kwon HJ, Cho JH. Intraoperative radiofrequency ablation for hepatocellular carcinoma in 112 patients with cirrhosis: a surgeon's view. Ann Surg Treat Res. 2016 Mar;90(3):147-56. doi: 10.4174/astr.2016.90.3.147. Epub 2016 Feb 26. PMID: 26942158; PMCID: PMC4773459.
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Ann Surg Treat Res. 2016 Mar;90(3):147-56. doi: 10.4174/astr.2016.90.3.147. Epub 2016 Feb 26.

Intraoperative radiofrequency ablation for hepatocellular carcinoma in 112 patients with cirrhosis: a surgeon's view.

Annals of surgical treatment and research

Jung Yeon Lee, Young Hoon Kim, Young Hoon Roh, Kyung Bin Roh, Kwan Woo Kim, Sung Hwa Kang, Yang Hyun Baek, Sung Wook Lee, Sang Young Han, Hee Jin Kwon, Jin Han Cho

Affiliations

  1. Department of Surgery, Dong-A University College of Medicine, Pusan, Korea.
  2. Department of Internal Medicine, Dong-A University College of Medicine, Pusan, Korea.
  3. Department of Radiology, Dong-A University College of Medicine, Pusan, Korea.

PMID: 26942158 PMCID: PMC4773459 DOI: 10.4174/astr.2016.90.3.147

Abstract

PURPOSE: This retrospective study was an investigation of overall survival (OS), disease-free survival (DFS) and prognostic factors affecting OS and DFS in cirrhotic patients who received intraoperative radiofrequency ablation (IORFA).

METHODS: Between April 2009 and November 2013, 112 patients (94 men, 84%; 18 women, 16%) underwent IORFA for 185 cases of hepatocellular carcinomas (HCC). Repeat IORFA was done in 9 patients during the same period (total of 121 treatments).

RESULTS: All patients were followed-up for at least 12 months (mean follow-up, 32 months). Surgical resection combined with IORFA was performed in 20 patients. The technical effectiveness at 1 week was 91.78% (111 of 121). Readmission was 9.1% (11 of 121) and the most common cause was ventral hernia. Procedure-related mortality was 2.7% (3 of 112) and continued fatal biliary leakage was 1.8% (2 of 112). Local recurrence developed in 10 patients (8.9%). Most recurrence was intrahepatic. Cumulative survival was assessed in 33 patients who received IORFA as primary treatment (naive patients) and 79 non-naive patients. The cumulative DFS and OS rate at l and 3 years was 54% and 24%, and 87% and 66%, respectively. Moderate ascites (P = 0.001), tumor located segment I (P = 0.001), portal vein thrombosis (P = 0.001) had poor survival were significant factors by multivariate analysis.

CONCLUSION: IORFA alone or in combination with surgical resection extends the spectrum of liver surgery. A fundamental understanding of RFA, additional comorbidities, and postablation complication are necessary to maximize the safety and efficacy of IORFA for treating HCC with cirrhosis.

Keywords: Hepatocellular carcinoma; Intraoperative; Radiofrequency ablation

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